The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells

Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells that mediate their functions. Integrins are usual...
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Gespeichert in:

Autor*in:	Hao Sun [verfasserIn] Frederic Lagarrigue [verfasserIn] Mark H. Ginsberg [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	integrin activation cell adhesion cell migration signaling blood cells

Übergeordnetes Werk:	In: Frontiers in Cell and Developmental Biology - Frontiers Media S.A., 2014, 10(2022)
Übergeordnetes Werk:	volume:10 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcell.2022.908622

Katalog-ID:	DOAJ029098793

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callnumber-first	Q - Science
author	Hao Sun
spellingShingle	Hao Sun misc QH301-705.5 misc integrin activation misc cell adhesion misc cell migration misc signaling misc blood cells misc Biology (General) The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
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topic_title	QH301-705.5 The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells integrin activation cell adhesion cell migration signaling blood cells
topic	misc QH301-705.5 misc integrin activation misc cell adhesion misc cell migration misc signaling misc blood cells misc Biology (General)
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title	The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
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title_full	The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
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title_sort	connection between rap1 and talin1 in the activation of integrins in blood cells
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title_auth	The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
abstract	Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells that mediate their functions. Integrins are usually in a resting state in blood cells until agonist stimulation results in a high-affinity conformation (“integrin activation”), which is central to integrins’ contribution to blood cells’ trafficking and functions. In this review, we summarize the mechanisms of integrin activation in blood cells with a focus on recent advances understanding of mechanisms whereby Rap1 regulates talin1-integrin interaction to trigger integrin activation in lymphocytes, platelets, and neutrophils.
abstractGer	Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells that mediate their functions. Integrins are usually in a resting state in blood cells until agonist stimulation results in a high-affinity conformation (“integrin activation”), which is central to integrins’ contribution to blood cells’ trafficking and functions. In this review, we summarize the mechanisms of integrin activation in blood cells with a focus on recent advances understanding of mechanisms whereby Rap1 regulates talin1-integrin interaction to trigger integrin activation in lymphocytes, platelets, and neutrophils.
abstract_unstemmed	Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells that mediate their functions. Integrins are usually in a resting state in blood cells until agonist stimulation results in a high-affinity conformation (“integrin activation”), which is central to integrins’ contribution to blood cells’ trafficking and functions. In this review, we summarize the mechanisms of integrin activation in blood cells with a focus on recent advances understanding of mechanisms whereby Rap1 regulates talin1-integrin interaction to trigger integrin activation in lymphocytes, platelets, and neutrophils.
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title_short	The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
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