Differences of Intestinal Flora in Children with Autism Spectrum Disorder with Different Levels of Serum Total 25-hydroxyvitamin D
Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
LUO Xin [verfasserIn] PANG Kun [verfasserIn] CHEN Jianxiong [verfasserIn] WANG Hongzhe [verfasserIn] XU Xinjie [verfasserIn] LI Bing [verfasserIn] JIA Xinmiao [verfasserIn] YOU Xin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Chinesisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: Xiehe Yixue Zazhi - Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2021, 13(2022), 5, Seite 812-820 |
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| Übergeordnetes Werk: |
volume:13 ; year:2022 ; number:5 ; pages:812-820 |
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| DOI / URN: |
10.12290/xhyxzz.2022-0254 |
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| Katalog-ID: |
DOAJ02919556X |
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| 520 | |a Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. | ||
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10.12290/xhyxzz.2022-0254 doi (DE-627)DOAJ02919556X (DE-599)DOAJ9fb75a86f6974f628ed617f288afae78 DE-627 ger DE-627 rakwb chi LUO Xin verfasserin aut Differences of Intestinal Flora in Children with Autism Spectrum Disorder with Different Levels of Serum Total 25-hydroxyvitamin D 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. gut microbiota autism spectrum disorder vitamin d Medicine R PANG Kun verfasserin aut CHEN Jianxiong verfasserin aut WANG Hongzhe verfasserin aut XU Xinjie verfasserin aut LI Bing verfasserin aut JIA Xinmiao verfasserin aut YOU Xin verfasserin aut In Xiehe Yixue Zazhi Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2021 13(2022), 5, Seite 812-820 (DE-627)DOAJ078626056 16749081 nnns volume:13 year:2022 number:5 pages:812-820 https://doi.org/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/article/9fb75a86f6974f628ed617f288afae78 kostenfrei https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/toc/1674-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 13 2022 5 812-820 |
| spelling |
10.12290/xhyxzz.2022-0254 doi (DE-627)DOAJ02919556X (DE-599)DOAJ9fb75a86f6974f628ed617f288afae78 DE-627 ger DE-627 rakwb chi LUO Xin verfasserin aut Differences of Intestinal Flora in Children with Autism Spectrum Disorder with Different Levels of Serum Total 25-hydroxyvitamin D 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. gut microbiota autism spectrum disorder vitamin d Medicine R PANG Kun verfasserin aut CHEN Jianxiong verfasserin aut WANG Hongzhe verfasserin aut XU Xinjie verfasserin aut LI Bing verfasserin aut JIA Xinmiao verfasserin aut YOU Xin verfasserin aut In Xiehe Yixue Zazhi Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2021 13(2022), 5, Seite 812-820 (DE-627)DOAJ078626056 16749081 nnns volume:13 year:2022 number:5 pages:812-820 https://doi.org/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/article/9fb75a86f6974f628ed617f288afae78 kostenfrei https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/toc/1674-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 13 2022 5 812-820 |
| allfields_unstemmed |
10.12290/xhyxzz.2022-0254 doi (DE-627)DOAJ02919556X (DE-599)DOAJ9fb75a86f6974f628ed617f288afae78 DE-627 ger DE-627 rakwb chi LUO Xin verfasserin aut Differences of Intestinal Flora in Children with Autism Spectrum Disorder with Different Levels of Serum Total 25-hydroxyvitamin D 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. gut microbiota autism spectrum disorder vitamin d Medicine R PANG Kun verfasserin aut CHEN Jianxiong verfasserin aut WANG Hongzhe verfasserin aut XU Xinjie verfasserin aut LI Bing verfasserin aut JIA Xinmiao verfasserin aut YOU Xin verfasserin aut In Xiehe Yixue Zazhi Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2021 13(2022), 5, Seite 812-820 (DE-627)DOAJ078626056 16749081 nnns volume:13 year:2022 number:5 pages:812-820 https://doi.org/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/article/9fb75a86f6974f628ed617f288afae78 kostenfrei https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/toc/1674-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 13 2022 5 812-820 |
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10.12290/xhyxzz.2022-0254 doi (DE-627)DOAJ02919556X (DE-599)DOAJ9fb75a86f6974f628ed617f288afae78 DE-627 ger DE-627 rakwb chi LUO Xin verfasserin aut Differences of Intestinal Flora in Children with Autism Spectrum Disorder with Different Levels of Serum Total 25-hydroxyvitamin D 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. gut microbiota autism spectrum disorder vitamin d Medicine R PANG Kun verfasserin aut CHEN Jianxiong verfasserin aut WANG Hongzhe verfasserin aut XU Xinjie verfasserin aut LI Bing verfasserin aut JIA Xinmiao verfasserin aut YOU Xin verfasserin aut In Xiehe Yixue Zazhi Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2021 13(2022), 5, Seite 812-820 (DE-627)DOAJ078626056 16749081 nnns volume:13 year:2022 number:5 pages:812-820 https://doi.org/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/article/9fb75a86f6974f628ed617f288afae78 kostenfrei https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/toc/1674-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 13 2022 5 812-820 |
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10.12290/xhyxzz.2022-0254 doi (DE-627)DOAJ02919556X (DE-599)DOAJ9fb75a86f6974f628ed617f288afae78 DE-627 ger DE-627 rakwb chi LUO Xin verfasserin aut Differences of Intestinal Flora in Children with Autism Spectrum Disorder with Different Levels of Serum Total 25-hydroxyvitamin D 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. gut microbiota autism spectrum disorder vitamin d Medicine R PANG Kun verfasserin aut CHEN Jianxiong verfasserin aut WANG Hongzhe verfasserin aut XU Xinjie verfasserin aut LI Bing verfasserin aut JIA Xinmiao verfasserin aut YOU Xin verfasserin aut In Xiehe Yixue Zazhi Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2021 13(2022), 5, Seite 812-820 (DE-627)DOAJ078626056 16749081 nnns volume:13 year:2022 number:5 pages:812-820 https://doi.org/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/article/9fb75a86f6974f628ed617f288afae78 kostenfrei https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0254 kostenfrei https://doaj.org/toc/1674-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 13 2022 5 812-820 |
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Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. 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Differences of Intestinal Flora in Children with Autism Spectrum Disorder with Different Levels of Serum Total 25-hydroxyvitamin D |
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Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. |
| abstractGer |
Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. |
| abstract_unstemmed |
Objective To investigate the differences of intestinal flora in Vitamin D adequacy and deficiency groups of children with autism spectrum disorder(ASD) and the correlation between serum total 25-hydroxyvitamin D [T-25(OH)D] levels and intestinal flora. Methods ASD children who attended the outpatient clinic of the department of Rheumatology and Clinical Immunology of Peking Union Medical College Hospital during October 2009 and February 2022 were retrospectively included in the study. According to the serum T-25(OH)D levels, they were divided into Vitamin D adequacy group[T-25(OH)D < 30 μg/L], Vitamin D insufficiency group[20 μg/L≤T-25(OH)D≤30 μg/L] and Vitamin D deficiency group[T-25(OH)D < 20 μg/L].Serum T-25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry. Human gut metagenome data from these children with ASD were analyzed using bioinformatics methods. Results 46 children with ASD who met the inclusion and exclusion criteria were included in the study. The numbers of patients in Vitamin D adequacy group, Vitamin D insufficiency group and Vitamin D deficiency group were respectively 15, 16 and 15. Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. This study provides partial evidence that children with ASD should be actively supplemented with vitamin D. |
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Linear discriminant analysis revealed that the bacteria abundance of Bilophila wadsworthia, Adlercreutzia equolifaciens, Asaccharobacter celatus and Escherichia coli were significantly enriched, while the bacteria abundance of Bacteroides fragilis and Hungatella hathewayi were significantly lower in the Vitamin D deficiency group. The relative abundance of Bilophila wadsworthia and Adlercreutzia equolifaciens were negatively correlated with serum T-25(OH)D levels(r=-0.45, fdr=0.055, P=0.002;r=-0.44, fdr=0.055, P=0.003), and the relative abundance of Bacteroides fragilis was positively correlated with serum T-25(OH)D levels (r=0.42, fdr=0.073, P=0.004). Conclusions Vitamin D deficiency in ASD may exacerbate ASD flora disorders, and decreased serum T-25(OH)D levels may facilitate potentially harmful bacteria but inhibit probiotic colonization. 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