The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review
Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more effici...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Badr Mohammed F. Alotaibi [verfasserIn] Mohammed A Kilani [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
|---|
| Schlagwörter: |
cutaneous squamous cell carcinoma |
|---|
| Übergeordnetes Werk: |
In: Journal of Nature and Science of Medicine - Wolters Kluwer Medknow Publications, 2020, 2(2019), 3, Seite 112-122 |
|---|---|
| Übergeordnetes Werk: |
volume:2 ; year:2019 ; number:3 ; pages:112-122 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.4103/JNSM.JNSM_55_18 |
|---|
| Katalog-ID: |
DOAJ029410533 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ029410533 | ||
| 003 | DE-627 | ||
| 005 | 20230307134928.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230226s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4103/JNSM.JNSM_55_18 |2 doi | |
| 035 | |a (DE-627)DOAJ029410533 | ||
| 035 | |a (DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RA1-1270 | |
| 100 | 0 | |a Badr Mohammed F. Alotaibi |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. | ||
| 650 | 4 | |a cutaneous squamous cell carcinoma | |
| 650 | 4 | |a de novo cutaneous squamous cell carcinoma | |
| 650 | 4 | |a incidence rate | |
| 650 | 4 | |a metastasis rate | |
| 650 | 4 | |a nonmelanoma skin cancer | |
| 650 | 4 | |a primary cutaneous squamous cell carcinoma | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 653 | 0 | |a Public aspects of medicine | |
| 700 | 0 | |a Mohammed A Kilani |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Journal of Nature and Science of Medicine |d Wolters Kluwer Medknow Publications, 2020 |g 2(2019), 3, Seite 112-122 |w (DE-627)1699081875 |x 25896288 |7 nnns |
| 773 | 1 | 8 | |g volume:2 |g year:2019 |g number:3 |g pages:112-122 |
| 856 | 4 | 0 | |u https://doi.org/10.4103/JNSM.JNSM_55_18 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5 |z kostenfrei |
| 856 | 4 | 0 | |u http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F. |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2589-627X |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2589-6288 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_39 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4367 | ||
| 912 | |a GBV_ILN_4700 | ||
| 951 | |a AR | ||
| 952 | |d 2 |j 2019 |e 3 |h 112-122 | ||
| author_variant |
b m f a bmfa m a k mak |
|---|---|
| matchkey_str |
article:25896288:2019----::hicdneaefeatssrmhpiayuaeusumuclcr |
| hierarchy_sort_str |
2019 |
| callnumber-subject-code |
RA |
| publishDate |
2019 |
| allfields |
10.4103/JNSM.JNSM_55_18 doi (DE-627)DOAJ029410533 (DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5 DE-627 ger DE-627 rakwb eng RA1-1270 Badr Mohammed F. Alotaibi verfasserin aut The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. cutaneous squamous cell carcinoma de novo cutaneous squamous cell carcinoma incidence rate metastasis rate nonmelanoma skin cancer primary cutaneous squamous cell carcinoma Medicine R Public aspects of medicine Mohammed A Kilani verfasserin aut In Journal of Nature and Science of Medicine Wolters Kluwer Medknow Publications, 2020 2(2019), 3, Seite 112-122 (DE-627)1699081875 25896288 nnns volume:2 year:2019 number:3 pages:112-122 https://doi.org/10.4103/JNSM.JNSM_55_18 kostenfrei https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5 kostenfrei http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F. kostenfrei https://doaj.org/toc/2589-627X Journal toc kostenfrei https://doaj.org/toc/2589-6288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2019 3 112-122 |
| spelling |
10.4103/JNSM.JNSM_55_18 doi (DE-627)DOAJ029410533 (DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5 DE-627 ger DE-627 rakwb eng RA1-1270 Badr Mohammed F. Alotaibi verfasserin aut The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. cutaneous squamous cell carcinoma de novo cutaneous squamous cell carcinoma incidence rate metastasis rate nonmelanoma skin cancer primary cutaneous squamous cell carcinoma Medicine R Public aspects of medicine Mohammed A Kilani verfasserin aut In Journal of Nature and Science of Medicine Wolters Kluwer Medknow Publications, 2020 2(2019), 3, Seite 112-122 (DE-627)1699081875 25896288 nnns volume:2 year:2019 number:3 pages:112-122 https://doi.org/10.4103/JNSM.JNSM_55_18 kostenfrei https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5 kostenfrei http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F. kostenfrei https://doaj.org/toc/2589-627X Journal toc kostenfrei https://doaj.org/toc/2589-6288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2019 3 112-122 |
| allfields_unstemmed |
10.4103/JNSM.JNSM_55_18 doi (DE-627)DOAJ029410533 (DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5 DE-627 ger DE-627 rakwb eng RA1-1270 Badr Mohammed F. Alotaibi verfasserin aut The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. cutaneous squamous cell carcinoma de novo cutaneous squamous cell carcinoma incidence rate metastasis rate nonmelanoma skin cancer primary cutaneous squamous cell carcinoma Medicine R Public aspects of medicine Mohammed A Kilani verfasserin aut In Journal of Nature and Science of Medicine Wolters Kluwer Medknow Publications, 2020 2(2019), 3, Seite 112-122 (DE-627)1699081875 25896288 nnns volume:2 year:2019 number:3 pages:112-122 https://doi.org/10.4103/JNSM.JNSM_55_18 kostenfrei https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5 kostenfrei http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F. kostenfrei https://doaj.org/toc/2589-627X Journal toc kostenfrei https://doaj.org/toc/2589-6288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2019 3 112-122 |
| allfieldsGer |
10.4103/JNSM.JNSM_55_18 doi (DE-627)DOAJ029410533 (DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5 DE-627 ger DE-627 rakwb eng RA1-1270 Badr Mohammed F. Alotaibi verfasserin aut The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. cutaneous squamous cell carcinoma de novo cutaneous squamous cell carcinoma incidence rate metastasis rate nonmelanoma skin cancer primary cutaneous squamous cell carcinoma Medicine R Public aspects of medicine Mohammed A Kilani verfasserin aut In Journal of Nature and Science of Medicine Wolters Kluwer Medknow Publications, 2020 2(2019), 3, Seite 112-122 (DE-627)1699081875 25896288 nnns volume:2 year:2019 number:3 pages:112-122 https://doi.org/10.4103/JNSM.JNSM_55_18 kostenfrei https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5 kostenfrei http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F. kostenfrei https://doaj.org/toc/2589-627X Journal toc kostenfrei https://doaj.org/toc/2589-6288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2019 3 112-122 |
| allfieldsSound |
10.4103/JNSM.JNSM_55_18 doi (DE-627)DOAJ029410533 (DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5 DE-627 ger DE-627 rakwb eng RA1-1270 Badr Mohammed F. Alotaibi verfasserin aut The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. cutaneous squamous cell carcinoma de novo cutaneous squamous cell carcinoma incidence rate metastasis rate nonmelanoma skin cancer primary cutaneous squamous cell carcinoma Medicine R Public aspects of medicine Mohammed A Kilani verfasserin aut In Journal of Nature and Science of Medicine Wolters Kluwer Medknow Publications, 2020 2(2019), 3, Seite 112-122 (DE-627)1699081875 25896288 nnns volume:2 year:2019 number:3 pages:112-122 https://doi.org/10.4103/JNSM.JNSM_55_18 kostenfrei https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5 kostenfrei http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F. kostenfrei https://doaj.org/toc/2589-627X Journal toc kostenfrei https://doaj.org/toc/2589-6288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2019 3 112-122 |
| language |
English |
| source |
In Journal of Nature and Science of Medicine 2(2019), 3, Seite 112-122 volume:2 year:2019 number:3 pages:112-122 |
| sourceStr |
In Journal of Nature and Science of Medicine 2(2019), 3, Seite 112-122 volume:2 year:2019 number:3 pages:112-122 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
cutaneous squamous cell carcinoma de novo cutaneous squamous cell carcinoma incidence rate metastasis rate nonmelanoma skin cancer primary cutaneous squamous cell carcinoma Medicine R Public aspects of medicine |
| isfreeaccess_bool |
true |
| container_title |
Journal of Nature and Science of Medicine |
| authorswithroles_txt_mv |
Badr Mohammed F. Alotaibi @@aut@@ Mohammed A Kilani @@aut@@ |
| publishDateDaySort_date |
2019-01-01T00:00:00Z |
| hierarchy_top_id |
1699081875 |
| id |
DOAJ029410533 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ029410533</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230307134928.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.4103/JNSM.JNSM_55_18</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ029410533</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1-1270</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Badr Mohammed F. Alotaibi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cutaneous squamous cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">de novo cutaneous squamous cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">incidence rate</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">metastasis rate</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nonmelanoma skin cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">primary cutaneous squamous cell carcinoma</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Public aspects of medicine</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohammed A Kilani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of Nature and Science of Medicine</subfield><subfield code="d">Wolters Kluwer Medknow Publications, 2020</subfield><subfield code="g">2(2019), 3, Seite 112-122</subfield><subfield code="w">(DE-627)1699081875</subfield><subfield code="x">25896288</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:2</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:112-122</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.4103/JNSM.JNSM_55_18</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F.</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2589-627X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2589-6288</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">2</subfield><subfield code="j">2019</subfield><subfield code="e">3</subfield><subfield code="h">112-122</subfield></datafield></record></collection>
|
| callnumber-first |
R - Medicine |
| author |
Badr Mohammed F. Alotaibi |
| spellingShingle |
Badr Mohammed F. Alotaibi misc RA1-1270 misc cutaneous squamous cell carcinoma misc de novo cutaneous squamous cell carcinoma misc incidence rate misc metastasis rate misc nonmelanoma skin cancer misc primary cutaneous squamous cell carcinoma misc Medicine misc R misc Public aspects of medicine The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review |
| authorStr |
Badr Mohammed F. Alotaibi |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)1699081875 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut |
| collection |
DOAJ |
| remote_str |
true |
| callnumber-label |
RA1-1270 |
| illustrated |
Not Illustrated |
| issn |
25896288 |
| topic_title |
RA1-1270 The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review cutaneous squamous cell carcinoma de novo cutaneous squamous cell carcinoma incidence rate metastasis rate nonmelanoma skin cancer primary cutaneous squamous cell carcinoma |
| topic |
misc RA1-1270 misc cutaneous squamous cell carcinoma misc de novo cutaneous squamous cell carcinoma misc incidence rate misc metastasis rate misc nonmelanoma skin cancer misc primary cutaneous squamous cell carcinoma misc Medicine misc R misc Public aspects of medicine |
| topic_unstemmed |
misc RA1-1270 misc cutaneous squamous cell carcinoma misc de novo cutaneous squamous cell carcinoma misc incidence rate misc metastasis rate misc nonmelanoma skin cancer misc primary cutaneous squamous cell carcinoma misc Medicine misc R misc Public aspects of medicine |
| topic_browse |
misc RA1-1270 misc cutaneous squamous cell carcinoma misc de novo cutaneous squamous cell carcinoma misc incidence rate misc metastasis rate misc nonmelanoma skin cancer misc primary cutaneous squamous cell carcinoma misc Medicine misc R misc Public aspects of medicine |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Journal of Nature and Science of Medicine |
| hierarchy_parent_id |
1699081875 |
| hierarchy_top_title |
Journal of Nature and Science of Medicine |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)1699081875 |
| title |
The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review |
| ctrlnum |
(DE-627)DOAJ029410533 (DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5 |
| title_full |
The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review |
| author_sort |
Badr Mohammed F. Alotaibi |
| journal |
Journal of Nature and Science of Medicine |
| journalStr |
Journal of Nature and Science of Medicine |
| callnumber-first-code |
R |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2019 |
| contenttype_str_mv |
txt |
| container_start_page |
112 |
| author_browse |
Badr Mohammed F. Alotaibi Mohammed A Kilani |
| container_volume |
2 |
| class |
RA1-1270 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Badr Mohammed F. Alotaibi |
| doi_str_mv |
10.4103/JNSM.JNSM_55_18 |
| author2-role |
verfasserin |
| title_sort |
incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: a literature review |
| callnumber |
RA1-1270 |
| title_auth |
The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review |
| abstract |
Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. |
| abstractGer |
Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. |
| abstract_unstemmed |
Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 |
| container_issue |
3 |
| title_short |
The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review |
| url |
https://doi.org/10.4103/JNSM.JNSM_55_18 https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5 http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F. https://doaj.org/toc/2589-627X https://doaj.org/toc/2589-6288 |
| remote_bool |
true |
| author2 |
Mohammed A Kilani |
| author2Str |
Mohammed A Kilani |
| ppnlink |
1699081875 |
| callnumber-subject |
RA - Public Medicine |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.4103/JNSM.JNSM_55_18 |
| callnumber-a |
RA1-1270 |
| up_date |
2024-07-03T22:45:16.918Z |
| _version_ |
1803599706245300224 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ029410533</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230307134928.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.4103/JNSM.JNSM_55_18</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ029410533</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJbad91ccc2a1e467db21d8eff705f5af5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1-1270</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Badr Mohammed F. Alotaibi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The incidence rate of metastasis from the primary cutaneous squamous cell carcinoma: A literature review</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Cutaneous squamous cell carcinomas (cSCCs) are the second highest nonmelanoma skin cancer, commonly targeting the head and neck region. Owing to its rising annual incidence, the actual rate of metastasis from the primary cSCC is needed to be investigated separately to develop more efficient management plans, hence nobly decreasing the incidence rate of metastasis overall. Materials and Methods: We conducted a literature review about the incidence rate of metastasis from the primary (or de novo) cSCC, based on two popular databases (PubMed and Cochrane), excluding different-purpose serving articles, for example, unrelated outcomes, case series, and case reports. Results: The mean incidence rate of metastasis from the primary cSCC is 10% (1.2–16.5). The least mean tumor size reportedly associated with regional and distant metastasis was 1.11 cm, and the least median thickness was 3 mm deep. Most of the metastatic tumors were of T1 stage before metastasis, and all metastases reported in the literature had more than one risk factor at a time. The mean follow-up duration was 4 years. Discussion: About half of the included literature carried a suspicion of selection bias, which threatens both their internal validity by overestimating the actual rate of metastasis and their external validity by seizing the reproducibility of the current evidence. Almost 85% of the metastasis was reported in the regional lymph nodes, while only a few cases involved distant anatomies at the time of diagnosis. This was consistent with other separate literatures. Conclusion: The mean incidence rate of metastasis from the primary cSCC tumors in our literature review is 10%, which is relatively higher than what was reported before in similar reviews. However, a large prospective study needs to be conducted to control and follow the involved prognostic factors, stratify them according to their risk factors, and minimize the risk of the previously reported bias in other reviews.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cutaneous squamous cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">de novo cutaneous squamous cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">incidence rate</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">metastasis rate</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nonmelanoma skin cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">primary cutaneous squamous cell carcinoma</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Public aspects of medicine</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohammed A Kilani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of Nature and Science of Medicine</subfield><subfield code="d">Wolters Kluwer Medknow Publications, 2020</subfield><subfield code="g">2(2019), 3, Seite 112-122</subfield><subfield code="w">(DE-627)1699081875</subfield><subfield code="x">25896288</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:2</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:112-122</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.4103/JNSM.JNSM_55_18</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/bad91ccc2a1e467db21d8eff705f5af5</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2019;volume=2;issue=3;spage=112;epage=122;aulast=F.</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2589-627X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2589-6288</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">2</subfield><subfield code="j">2019</subfield><subfield code="e">3</subfield><subfield code="h">112-122</subfield></datafield></record></collection>
|
| score |
7.3994074 |