INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY

Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to ex...
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Autor*in:	Cuneyt Kocas [verfasserIn] Okay Abaci [verfasserIn] Kadriye Orta Kilickesmez [verfasserIn] Ferid Aliyev [verfasserIn] Yusuf Atayev [verfasserIn] Cengizhan Yusuf [verfasserIn] Cengiz Celiker [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2014

Schlagwörter:	crt repolarization dispersion major arrhythmic events qt dispersion

Übergeordnetes Werk:	In: Российский кардиологический журнал - «FIRMA «SILICEA» LLC, 2019, (2014), 4-ENG, Seite 10-14
Übergeordnetes Werk:	year:2014 ; number:4-ENG ; pages:10-14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15829/1560-4071-2014-4-ENG-10-14

Katalog-ID:	DOAJ029441277

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520			\|a Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up.
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700	0		\|a Cengiz Celiker \|e verfasserin \|4 aut
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allfields	10.15829/1560-4071-2014-4-ENG-10-14 doi (DE-627)DOAJ029441277 (DE-599)DOAJ1b34ac6d58524dba8b8f0d8c163e27e9 DE-627 ger DE-627 rakwb rus RC666-701 Cuneyt Kocas verfasserin aut INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up. crt repolarization dispersion major arrhythmic events qt dispersion Diseases of the circulatory (Cardiovascular) system Okay Abaci verfasserin aut Kadriye Orta Kilickesmez verfasserin aut Ferid Aliyev verfasserin aut Yusuf Atayev verfasserin aut Cengizhan Yusuf verfasserin aut Cengiz Celiker verfasserin aut In Российский кардиологический журнал «FIRMA «SILICEA» LLC, 2019 (2014), 4-ENG, Seite 10-14 (DE-627)1760594547 26187620 nnns year:2014 number:4-ENG pages:10-14 https://doi.org/10.15829/1560-4071-2014-4-ENG-10-14 kostenfrei https://doaj.org/article/1b34ac6d58524dba8b8f0d8c163e27e9 kostenfrei https://russjcardiol.elpub.ru/jour/article/view/600 kostenfrei https://doaj.org/toc/1560-4071 Journal toc kostenfrei https://doaj.org/toc/2618-7620 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2014 4-ENG 10-14
spelling	10.15829/1560-4071-2014-4-ENG-10-14 doi (DE-627)DOAJ029441277 (DE-599)DOAJ1b34ac6d58524dba8b8f0d8c163e27e9 DE-627 ger DE-627 rakwb rus RC666-701 Cuneyt Kocas verfasserin aut INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up. crt repolarization dispersion major arrhythmic events qt dispersion Diseases of the circulatory (Cardiovascular) system Okay Abaci verfasserin aut Kadriye Orta Kilickesmez verfasserin aut Ferid Aliyev verfasserin aut Yusuf Atayev verfasserin aut Cengizhan Yusuf verfasserin aut Cengiz Celiker verfasserin aut In Российский кардиологический журнал «FIRMA «SILICEA» LLC, 2019 (2014), 4-ENG, Seite 10-14 (DE-627)1760594547 26187620 nnns year:2014 number:4-ENG pages:10-14 https://doi.org/10.15829/1560-4071-2014-4-ENG-10-14 kostenfrei https://doaj.org/article/1b34ac6d58524dba8b8f0d8c163e27e9 kostenfrei https://russjcardiol.elpub.ru/jour/article/view/600 kostenfrei https://doaj.org/toc/1560-4071 Journal toc kostenfrei https://doaj.org/toc/2618-7620 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2014 4-ENG 10-14
allfields_unstemmed	10.15829/1560-4071-2014-4-ENG-10-14 doi (DE-627)DOAJ029441277 (DE-599)DOAJ1b34ac6d58524dba8b8f0d8c163e27e9 DE-627 ger DE-627 rakwb rus RC666-701 Cuneyt Kocas verfasserin aut INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up. crt repolarization dispersion major arrhythmic events qt dispersion Diseases of the circulatory (Cardiovascular) system Okay Abaci verfasserin aut Kadriye Orta Kilickesmez verfasserin aut Ferid Aliyev verfasserin aut Yusuf Atayev verfasserin aut Cengizhan Yusuf verfasserin aut Cengiz Celiker verfasserin aut In Российский кардиологический журнал «FIRMA «SILICEA» LLC, 2019 (2014), 4-ENG, Seite 10-14 (DE-627)1760594547 26187620 nnns year:2014 number:4-ENG pages:10-14 https://doi.org/10.15829/1560-4071-2014-4-ENG-10-14 kostenfrei https://doaj.org/article/1b34ac6d58524dba8b8f0d8c163e27e9 kostenfrei https://russjcardiol.elpub.ru/jour/article/view/600 kostenfrei https://doaj.org/toc/1560-4071 Journal toc kostenfrei https://doaj.org/toc/2618-7620 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2014 4-ENG 10-14
allfieldsGer	10.15829/1560-4071-2014-4-ENG-10-14 doi (DE-627)DOAJ029441277 (DE-599)DOAJ1b34ac6d58524dba8b8f0d8c163e27e9 DE-627 ger DE-627 rakwb rus RC666-701 Cuneyt Kocas verfasserin aut INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up. crt repolarization dispersion major arrhythmic events qt dispersion Diseases of the circulatory (Cardiovascular) system Okay Abaci verfasserin aut Kadriye Orta Kilickesmez verfasserin aut Ferid Aliyev verfasserin aut Yusuf Atayev verfasserin aut Cengizhan Yusuf verfasserin aut Cengiz Celiker verfasserin aut In Российский кардиологический журнал «FIRMA «SILICEA» LLC, 2019 (2014), 4-ENG, Seite 10-14 (DE-627)1760594547 26187620 nnns year:2014 number:4-ENG pages:10-14 https://doi.org/10.15829/1560-4071-2014-4-ENG-10-14 kostenfrei https://doaj.org/article/1b34ac6d58524dba8b8f0d8c163e27e9 kostenfrei https://russjcardiol.elpub.ru/jour/article/view/600 kostenfrei https://doaj.org/toc/1560-4071 Journal toc kostenfrei https://doaj.org/toc/2618-7620 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2014 4-ENG 10-14
allfieldsSound	10.15829/1560-4071-2014-4-ENG-10-14 doi (DE-627)DOAJ029441277 (DE-599)DOAJ1b34ac6d58524dba8b8f0d8c163e27e9 DE-627 ger DE-627 rakwb rus RC666-701 Cuneyt Kocas verfasserin aut INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up. crt repolarization dispersion major arrhythmic events qt dispersion Diseases of the circulatory (Cardiovascular) system Okay Abaci verfasserin aut Kadriye Orta Kilickesmez verfasserin aut Ferid Aliyev verfasserin aut Yusuf Atayev verfasserin aut Cengizhan Yusuf verfasserin aut Cengiz Celiker verfasserin aut In Российский кардиологический журнал «FIRMA «SILICEA» LLC, 2019 (2014), 4-ENG, Seite 10-14 (DE-627)1760594547 26187620 nnns year:2014 number:4-ENG pages:10-14 https://doi.org/10.15829/1560-4071-2014-4-ENG-10-14 kostenfrei https://doaj.org/article/1b34ac6d58524dba8b8f0d8c163e27e9 kostenfrei https://russjcardiol.elpub.ru/jour/article/view/600 kostenfrei https://doaj.org/toc/1560-4071 Journal toc kostenfrei https://doaj.org/toc/2618-7620 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2014 4-ENG 10-14
language	Russian
source	In Российский кардиологический журнал (2014), 4-ENG, Seite 10-14 year:2014 number:4-ENG pages:10-14
sourceStr	In Российский кардиологический журнал (2014), 4-ENG, Seite 10-14 year:2014 number:4-ENG pages:10-14
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topic_facet	crt repolarization dispersion major arrhythmic events qt dispersion Diseases of the circulatory (Cardiovascular) system
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container_title	Российский кардиологический журнал
authorswithroles_txt_mv	Cuneyt Kocas @@aut@@ Okay Abaci @@aut@@ Kadriye Orta Kilickesmez @@aut@@ Ferid Aliyev @@aut@@ Yusuf Atayev @@aut@@ Cengizhan Yusuf @@aut@@ Cengiz Celiker @@aut@@
publishDateDaySort_date	2014-01-01T00:00:00Z
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Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration &gt;120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. 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callnumber-first	R - Medicine
author	Cuneyt Kocas
spellingShingle	Cuneyt Kocas misc RC666-701 misc crt misc repolarization dispersion misc major arrhythmic events misc qt dispersion misc Diseases of the circulatory (Cardiovascular) system INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY
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topic_title	RC666-701 INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY crt repolarization dispersion major arrhythmic events qt dispersion
topic	misc RC666-701 misc crt misc repolarization dispersion misc major arrhythmic events misc qt dispersion misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc crt misc repolarization dispersion misc major arrhythmic events misc qt dispersion misc Diseases of the circulatory (Cardiovascular) system
topic_browse	misc RC666-701 misc crt misc repolarization dispersion misc major arrhythmic events misc qt dispersion misc Diseases of the circulatory (Cardiovascular) system
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title	INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY
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title_full	INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY
author_sort	Cuneyt Kocas
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author_browse	Cuneyt Kocas Okay Abaci Kadriye Orta Kilickesmez Ferid Aliyev Yusuf Atayev Cengizhan Yusuf Cengiz Celiker
class	RC666-701
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author-letter	Cuneyt Kocas
doi_str_mv	10.15829/1560-4071-2014-4-ENG-10-14
author2-role	verfasserin
title_sort	increase in qtc dispersion predicts arrhythmic events in patients with cardiac resynchronization therapy
callnumber	RC666-701
title_auth	INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY
abstract	Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up.
abstractGer	Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up.
abstract_unstemmed	Aim. Benefits of CRT on mortality and morbidity in patients with severe CHF are clear but the effect of CRT on sudden cardiac death is more controversial. It has been suggested that CRT may catalyze arrhythmogenicity by reversing the normal depolarization pattern. The purpose of this study was to examine the effect of CRT on dispersion of repolarization as assessed by ECG. We also sought to determine the value of dispersion of repolarization ECG parameters in predicting the occurrence of major arrhythmic events (MAE) in follow-up.Material and methods. A total of 48 patients with end-stage heart failure and QRS duration >120 ms underwent CRT. QT dispersion (QTd), T peak t end interval (Tpe) and T peak t end dispersion (Tpe dispersion) were measured before and immediately after CRT implantation. All patients were followed at least 12 months for ventricular tachycardia or fibrillation that were treated with antitachicardia pace or cardioversion.Results. Over 16±7.1 months, 14 patients had a MAE. Compared to baseline, after CRT, QTc dispersion (84.66±37.7 vs 100.36±47.4, p=0.04) and Tpe interval (104.1±20.4 vs 122.03±33, p=0.02) increased significantly. Increase in QTD (ΔQTD) (31.66±39.5 vs 5.57±5.59, p=0.03), and QTc dispersion (ΔQTc dispersion) (40.19±46.6 vs 4.39±14.35, p=0.04) from baseline was signifcantly higher in MAE group. In multiple regression analyses, ΔQTc dispersion predicted MAE (p=0.045, CI: 1.000–1.033).Conclusion. Immediately after CRT implantation QTc dispersion and Tpe interval increases and increase in QTc dispersion predicts MAE in one year follow up.
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title_short	INCREASE IN QTC DISPERSION PREDICTS ARRHYTHMIC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY
url	https://doi.org/10.15829/1560-4071-2014-4-ENG-10-14 https://doaj.org/article/1b34ac6d58524dba8b8f0d8c163e27e9 https://russjcardiol.elpub.ru/jour/article/view/600 https://doaj.org/toc/1560-4071 https://doaj.org/toc/2618-7620
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