CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS

The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study....
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Autor*in:	O. E. Savelieva [verfasserIn] L. A. Tashireva [verfasserIn] M. A. Buldakov [verfasserIn] R. H. Mukhamedzhanov [verfasserIn] E. V. Kaigorodova [verfasserIn] E. V. Denisov [verfasserIn] M. V. Zavyalova [verfasserIn] V. M. Perelmuter [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2018

Schlagwörter:	cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы

Übergeordnetes Werk:	In: Сибирский онкологический журнал - Russian Academy of Sciences, Tomsk National Research Medical Center, 2017, 17(2018), 4, Seite 75-80
Übergeordnetes Werk:	volume:17 ; year:2018 ; number:4 ; pages:75-80

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.21294/1814-4861-2018-17-4-75-80

Katalog-ID:	DOAJ02947180X

Internformat


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520			\|a The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets.
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650		4	\|a одиночные (дискретные) опухолевые клетки
650		4	\|a эпителиально-мезенхимальный переход
650		4	\|a рак молочной железы
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a L. A. Tashireva \|e verfasserin \|4 aut
700	0		\|a M. A. Buldakov \|e verfasserin \|4 aut
700	0		\|a R. H. Mukhamedzhanov \|e verfasserin \|4 aut
700	0		\|a E. V. Kaigorodova \|e verfasserin \|4 aut
700	0		\|a E. V. Denisov \|e verfasserin \|4 aut
700	0		\|a M. V. Zavyalova \|e verfasserin \|4 aut
700	0		\|a V. M. Perelmuter \|e verfasserin \|4 aut
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912			\|a GBV_ILN_95
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912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
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912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
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Indexfelder

author_variant	o e s oes l a t lat m a b mab r h m rhm e v k evk e v d evd m v z mvz v m p vmp
matchkey_str	article:23123168:2018----::xrepesoidfeetustoccadigeeah
hierarchy_sort_str	2018
callnumber-subject-code	RC
publishDate	2018
allfields	10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80
spelling	10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80
allfields_unstemmed	10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80
allfieldsGer	10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80
allfieldsSound	10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80
language	Russian
source	In Сибирский онкологический журнал 17(2018), 4, Seite 75-80 volume:17 year:2018 number:4 pages:75-80
sourceStr	In Сибирский онкологический журнал 17(2018), 4, Seite 75-80 volume:17 year:2018 number:4 pages:75-80
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Сибирский онкологический журнал
authorswithroles_txt_mv	O. E. Savelieva @@aut@@ L. A. Tashireva @@aut@@ M. A. Buldakov @@aut@@ R. H. Mukhamedzhanov @@aut@@ E. V. Kaigorodova @@aut@@ E. V. Denisov @@aut@@ M. V. Zavyalova @@aut@@ V. M. Perelmuter @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	731335074
id	DOAJ02947180X
language_de	russisch
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E. Savelieva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. 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callnumber-first	R - Medicine
author	O. E. Savelieva
spellingShingle	O. E. Savelieva misc RC254-282 misc cxcr4 misc циркулирующие опухолевые клетки misc стволовые опухолевые клетки misc одиночные (дискретные) опухолевые клетки misc эпителиально-мезенхимальный переход misc рак молочной железы misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS
authorStr	O. E. Savelieva
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topic_title	RC254-282 CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы
topic	misc RC254-282 misc cxcr4 misc циркулирующие опухолевые клетки misc стволовые опухолевые клетки misc одиночные (дискретные) опухолевые клетки misc эпителиально-мезенхимальный переход misc рак молочной железы misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc cxcr4 misc циркулирующие опухолевые клетки misc стволовые опухолевые клетки misc одиночные (дискретные) опухолевые клетки misc эпителиально-мезенхимальный переход misc рак молочной железы misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc cxcr4 misc циркулирующие опухолевые клетки misc стволовые опухолевые клетки misc одиночные (дискретные) опухолевые клетки misc эпителиально-мезенхимальный переход misc рак молочной железы misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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hierarchy_parent_title	Сибирский онкологический журнал
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title	CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS
ctrlnum	(DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03
title_full	CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS
author_sort	O. E. Savelieva
journal	Сибирский онкологический журнал
journalStr	Сибирский онкологический журнал
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author_browse	O. E. Savelieva L. A. Tashireva M. A. Buldakov R. H. Mukhamedzhanov E. V. Kaigorodova E. V. Denisov M. V. Zavyalova V. M. Perelmuter
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class	RC254-282
format_se	Elektronische Aufsätze
author-letter	O. E. Savelieva
doi_str_mv	10.21294/1814-4861-2018-17-4-75-80
author2-role	verfasserin
title_sort	cxcr4 expression in different subsets of ctcs and single (detached) breast cancer cells
callnumber	RC254-282
title_auth	CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS
abstract	The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets.
abstractGer	The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets.
abstract_unstemmed	The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets.
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container_issue	4
title_short	CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS
url	https://doi.org/10.21294/1814-4861-2018-17-4-75-80 https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 https://www.siboncoj.ru/jour/article/view/819 https://doaj.org/toc/1814-4861 https://doaj.org/toc/2312-3168
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author2	L. A. Tashireva M. A. Buldakov R. H. Mukhamedzhanov E. V. Kaigorodova E. V. Denisov M. V. Zavyalova V. M. Perelmuter
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up_date	2024-07-03T23:03:17.139Z
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