CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS
The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study....
Ausführliche Beschreibung
Autor*in: |
O. E. Savelieva [verfasserIn] L. A. Tashireva [verfasserIn] M. A. Buldakov [verfasserIn] R. H. Mukhamedzhanov [verfasserIn] E. V. Kaigorodova [verfasserIn] E. V. Denisov [verfasserIn] M. V. Zavyalova [verfasserIn] V. M. Perelmuter [verfasserIn] |
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E-Artikel |
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Sprache: |
Russisch |
Erschienen: |
2018 |
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Schlagwörter: |
циркулирующие опухолевые клетки одиночные (дискретные) опухолевые клетки |
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Übergeordnetes Werk: |
In: Сибирский онкологический журнал - Russian Academy of Sciences, Tomsk National Research Medical Center, 2017, 17(2018), 4, Seite 75-80 |
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Übergeordnetes Werk: |
volume:17 ; year:2018 ; number:4 ; pages:75-80 |
Links: |
Link aufrufen |
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DOI / URN: |
10.21294/1814-4861-2018-17-4-75-80 |
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Katalog-ID: |
DOAJ02947180X |
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520 | |a The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. | ||
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653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
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700 | 0 | |a V. M. Perelmuter |e verfasserin |4 aut | |
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10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80 |
spelling |
10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80 |
allfields_unstemmed |
10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80 |
allfieldsGer |
10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80 |
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10.21294/1814-4861-2018-17-4-75-80 doi (DE-627)DOAJ02947180X (DE-599)DOAJc60039fb012f4002b7f57d5bfb934b03 DE-627 ger DE-627 rakwb rus RC254-282 O. E. Savelieva verfasserin aut CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы Neoplasms. Tumors. Oncology. Including cancer and carcinogens L. A. Tashireva verfasserin aut M. A. Buldakov verfasserin aut R. H. Mukhamedzhanov verfasserin aut E. V. Kaigorodova verfasserin aut E. V. Denisov verfasserin aut M. V. Zavyalova verfasserin aut V. M. Perelmuter verfasserin aut In Сибирский онкологический журнал Russian Academy of Sciences, Tomsk National Research Medical Center, 2017 17(2018), 4, Seite 75-80 (DE-627)731335074 (DE-600)2693095-X 23123168 nnns volume:17 year:2018 number:4 pages:75-80 https://doi.org/10.21294/1814-4861-2018-17-4-75-80 kostenfrei https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 kostenfrei https://www.siboncoj.ru/jour/article/view/819 kostenfrei https://doaj.org/toc/1814-4861 Journal toc kostenfrei https://doaj.org/toc/2312-3168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 4 75-80 |
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RC254-282 CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS cxcr4 циркулирующие опухолевые клетки стволовые опухолевые клетки одиночные (дискретные) опухолевые клетки эпителиально-мезенхимальный переход рак молочной железы |
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O. E. Savelieva L. A. Tashireva M. A. Buldakov R. H. Mukhamedzhanov E. V. Kaigorodova E. V. Denisov M. V. Zavyalova V. M. Perelmuter |
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Elektronische Aufsätze |
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O. E. Savelieva |
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10.21294/1814-4861-2018-17-4-75-80 |
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cxcr4 expression in different subsets of ctcs and single (detached) breast cancer cells |
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RC254-282 |
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CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS |
abstract |
The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. |
abstractGer |
The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. |
abstract_unstemmed |
The aim of this study was to assess CXCR4 expression in different subsets of CTCs and single (detached) breast cancer cells.Materials and methods. Thirty five patients with invasive breast carcinoma of no specialtype (IC NST) (T1-4N0-2M0), between 29 and 69 years of age were included in this study. Different subsets of CTCs with CXCR4 expression were evaluated by flow cytometry. A confocal microscopy was used to assess CXCR4 expression in different subsets of single (detached) cancer cells in breast tissue.Results. The CXCR4 was expressed in CTCs without stem-like and EMT phenotype, in CTCs with EMT but not stem markers and in stem-like CTCs without EMT features. In all blood samples, the CXCR4 expression in CTCs with stem-like and EMT phenotype was absent. In breast tumor the CXCR4 was expressed in the non stemlike single (detached) breast cancer cells with EMT features, in the single (detached) breast cancer cells with stem and EMT features. In all tumor samples the stem-like or non stem-like single (detached) breast cancer cells without EMT features were absent.Conclusions. Different subsets of the CTCs exhibited CXCR4. The CXCR4 expression did not depend on the presence or absence of stem or/and EMT features in tumor cells. We showed that some subsets of single (detached) breast cancer cells in the primary tumor were characterized by the ability to express CXCR4 and may be a source of the respective CTC subsets. |
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CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCs AND SINGLE (DETACHED) BREAST CANCER CELLS |
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https://doi.org/10.21294/1814-4861-2018-17-4-75-80 https://doaj.org/article/c60039fb012f4002b7f57d5bfb934b03 https://www.siboncoj.ru/jour/article/view/819 https://doaj.org/toc/1814-4861 https://doaj.org/toc/2312-3168 |
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L. A. Tashireva M. A. Buldakov R. H. Mukhamedzhanov E. V. Kaigorodova E. V. Denisov M. V. Zavyalova V. M. Perelmuter |
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L. A. Tashireva M. A. Buldakov R. H. Mukhamedzhanov E. V. Kaigorodova E. V. Denisov M. V. Zavyalova V. M. Perelmuter |
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