VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS

A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration...
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Autor*in:	S. S. Vlasov [verfasserIn] S. V. Krivoshchekov [verfasserIn] M. K. Zamanova [verfasserIn] M. V. Belousov [verfasserIn] A. M. Guriev [verfasserIn] M. S. Yusubov [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2019

Schlagwörter:	хромато-масс-спектрометрия гексафторид серы уз-контрастные средства

Übergeordnetes Werk:	In: Разработка и регистрация лекарственных средств - LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2020, (2019), 4, Seite 174-179
Übergeordnetes Werk:	year:2019 ; number:4 ; pages:174-179

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ029610168

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520			\|a A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively.
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allfields	(DE-627)DOAJ029610168 (DE-599)DOAJ6646330ff02045c1a5a28536d09b3a33 DE-627 ger DE-627 rakwb rus HD9665-9675 S. S. Vlasov verfasserin aut VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively. хромато-масс-спектрометрия гексафторид серы уз-контрастные средства Pharmaceutical industry S. V. Krivoshchekov verfasserin aut M. K. Zamanova verfasserin aut M. V. Belousov verfasserin aut A. M. Guriev verfasserin aut M. S. Yusubov verfasserin aut In Разработка и регистрация лекарственных средств LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2020 (2019), 4, Seite 174-179 (DE-627)1760622966 26585049 nnns year:2019 number:4 pages:174-179 https://doaj.org/article/6646330ff02045c1a5a28536d09b3a33 kostenfrei https://www.pharmjournal.ru/jour/article/view/171 kostenfrei https://doaj.org/toc/2305-2066 Journal toc kostenfrei https://doaj.org/toc/2658-5049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2019 4 174-179
spelling	(DE-627)DOAJ029610168 (DE-599)DOAJ6646330ff02045c1a5a28536d09b3a33 DE-627 ger DE-627 rakwb rus HD9665-9675 S. S. Vlasov verfasserin aut VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively. хромато-масс-спектрометрия гексафторид серы уз-контрастные средства Pharmaceutical industry S. V. Krivoshchekov verfasserin aut M. K. Zamanova verfasserin aut M. V. Belousov verfasserin aut A. M. Guriev verfasserin aut M. S. Yusubov verfasserin aut In Разработка и регистрация лекарственных средств LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2020 (2019), 4, Seite 174-179 (DE-627)1760622966 26585049 nnns year:2019 number:4 pages:174-179 https://doaj.org/article/6646330ff02045c1a5a28536d09b3a33 kostenfrei https://www.pharmjournal.ru/jour/article/view/171 kostenfrei https://doaj.org/toc/2305-2066 Journal toc kostenfrei https://doaj.org/toc/2658-5049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2019 4 174-179
allfields_unstemmed	(DE-627)DOAJ029610168 (DE-599)DOAJ6646330ff02045c1a5a28536d09b3a33 DE-627 ger DE-627 rakwb rus HD9665-9675 S. S. Vlasov verfasserin aut VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively. хромато-масс-спектрометрия гексафторид серы уз-контрастные средства Pharmaceutical industry S. V. Krivoshchekov verfasserin aut M. K. Zamanova verfasserin aut M. V. Belousov verfasserin aut A. M. Guriev verfasserin aut M. S. Yusubov verfasserin aut In Разработка и регистрация лекарственных средств LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2020 (2019), 4, Seite 174-179 (DE-627)1760622966 26585049 nnns year:2019 number:4 pages:174-179 https://doaj.org/article/6646330ff02045c1a5a28536d09b3a33 kostenfrei https://www.pharmjournal.ru/jour/article/view/171 kostenfrei https://doaj.org/toc/2305-2066 Journal toc kostenfrei https://doaj.org/toc/2658-5049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2019 4 174-179
allfieldsGer	(DE-627)DOAJ029610168 (DE-599)DOAJ6646330ff02045c1a5a28536d09b3a33 DE-627 ger DE-627 rakwb rus HD9665-9675 S. S. Vlasov verfasserin aut VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively. хромато-масс-спектрометрия гексафторид серы уз-контрастные средства Pharmaceutical industry S. V. Krivoshchekov verfasserin aut M. K. Zamanova verfasserin aut M. V. Belousov verfasserin aut A. M. Guriev verfasserin aut M. S. Yusubov verfasserin aut In Разработка и регистрация лекарственных средств LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2020 (2019), 4, Seite 174-179 (DE-627)1760622966 26585049 nnns year:2019 number:4 pages:174-179 https://doaj.org/article/6646330ff02045c1a5a28536d09b3a33 kostenfrei https://www.pharmjournal.ru/jour/article/view/171 kostenfrei https://doaj.org/toc/2305-2066 Journal toc kostenfrei https://doaj.org/toc/2658-5049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2019 4 174-179
allfieldsSound	(DE-627)DOAJ029610168 (DE-599)DOAJ6646330ff02045c1a5a28536d09b3a33 DE-627 ger DE-627 rakwb rus HD9665-9675 S. S. Vlasov verfasserin aut VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively. хромато-масс-спектрометрия гексафторид серы уз-контрастные средства Pharmaceutical industry S. V. Krivoshchekov verfasserin aut M. K. Zamanova verfasserin aut M. V. Belousov verfasserin aut A. M. Guriev verfasserin aut M. S. Yusubov verfasserin aut In Разработка и регистрация лекарственных средств LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2020 (2019), 4, Seite 174-179 (DE-627)1760622966 26585049 nnns year:2019 number:4 pages:174-179 https://doaj.org/article/6646330ff02045c1a5a28536d09b3a33 kostenfrei https://www.pharmjournal.ru/jour/article/view/171 kostenfrei https://doaj.org/toc/2305-2066 Journal toc kostenfrei https://doaj.org/toc/2658-5049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2019 4 174-179
language	Russian
source	In Разработка и регистрация лекарственных средств (2019), 4, Seite 174-179 year:2019 number:4 pages:174-179
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authorswithroles_txt_mv	S. S. Vlasov @@aut@@ S. V. Krivoshchekov @@aut@@ M. K. Zamanova @@aut@@ M. V. Belousov @@aut@@ A. M. Guriev @@aut@@ M. S. Yusubov @@aut@@
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callnumber-first	H - Social Science
author	S. S. Vlasov
spellingShingle	S. S. Vlasov misc HD9665-9675 misc хромато-масс-спектрометрия misc гексафторид серы misc уз-контрастные средства misc Pharmaceutical industry VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS
authorStr	S. S. Vlasov
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topic_title	HD9665-9675 VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS хромато-масс-спектрометрия гексафторид серы уз-контрастные средства
topic	misc HD9665-9675 misc хромато-масс-спектрометрия misc гексафторид серы misc уз-контрастные средства misc Pharmaceutical industry
topic_unstemmed	misc HD9665-9675 misc хромато-масс-спектрометрия misc гексафторид серы misc уз-контрастные средства misc Pharmaceutical industry
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title	VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS
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title_full	VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS
author_sort	S. S. Vlasov
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author_browse	S. S. Vlasov S. V. Krivoshchekov M. K. Zamanova M. V. Belousov A. M. Guriev M. S. Yusubov
class	HD9665-9675
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title_sort	validation method for determination of the sulfur hexafluoride in plasma samples of experimental animals
callnumber	HD9665-9675
title_auth	VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS
abstract	A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively.
abstractGer	A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively.
abstract_unstemmed	A new GCMS-based method for quantitative determination of active substance of new contrast drug based on sulfur hexafluoride (SH) in the rat blood plasma is produced. A ratio plot of peak area of sulfur hexafluoride to peak area of internal standard toluene [y, S(SH)/S(toluene)] versus concentration of sulfur hexafluoride (x, µL/mL) was linear over 0.003-0.500 µL/mL. The calibration graph can be described by the equation y=0.9526x+0.0037 (r2=0.9990). Limit of quantitation (LOQ) (signal-to-noise 10,12) was 0.003 µL/mL. Inter- and intra-serial accuracy related to nominal concentrations were 100.40-101.20% and 86.67-110.0%, respectively. The RSD values for inter- and intra-serial accuracy were 3.68-4.15% and 1.23-10.68%, respectively. The samples of the same series with SH concentrations 0.01 µL/mL and 0.50 µL/mL were analyzed in order to determine the stability. Samples were stored for 24 hours to determine the short-term stability. To determine the long-term stability Samples were stored for 25 days. Short-term stability at room temperature were 0.52% and 1.86% and long-term stability at -20 °C were -90.43% and -81.81% for SH concentrations 0.01 µL/mL and 0.50 µl/ml, respectively. Accuracy during freezing and thawing of samples were 102.30% and 100.10% and RSD values were 5.40% and 1.50%, respectively.
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title_short	VALIDATION METHOD FOR DETERMINATION OF THE SULFUR HEXAFLUORIDE IN PLASMA SAMPLES OF EXPERIMENTAL ANIMALS
url	https://doaj.org/article/6646330ff02045c1a5a28536d09b3a33 https://www.pharmjournal.ru/jour/article/view/171 https://doaj.org/toc/2305-2066 https://doaj.org/toc/2658-5049
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author2	S. V. Krivoshchekov M. K. Zamanova M. V. Belousov A. M. Guriev M. S. Yusubov
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up_date	2024-07-03T23:39:18.432Z
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