Justification of local anesthetic and choice of its concentration in composition of dental gel
Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lid...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yu. S. Maslii [verfasserIn] O. О. Hrudnytska [verfasserIn] O. A. Ruban [verfasserIn] G. V. Zaychenko [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Ukrainisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Фармацевтичний журнал - The State Expert Center of the Ministry of Health of Ukraine, 2019, 3(2019), 3, Seite 49-55 |
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| Übergeordnetes Werk: |
volume:3 ; year:2019 ; number:3 ; pages:49-55 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.32352/0367-3057.3.19.06 |
|---|
| Katalog-ID: |
DOAJ029778395 |
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| 520 | |a Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. | ||
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10.32352/0367-3057.3.19.06 doi (DE-627)DOAJ029778395 (DE-599)DOAJ1d4c940437fe4c35bf5a953db40b3a88 DE-627 ger DE-627 rakwb ukr RM1-950 RS1-441 Yu. S. Maslii verfasserin aut Justification of local anesthetic and choice of its concentration in composition of dental gel 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. dental gel lidocaine hydrochloride local anesthetic activity Therapeutics. Pharmacology Pharmacy and materia medica O. О. Hrudnytska verfasserin aut O. A. Ruban verfasserin aut G. V. Zaychenko verfasserin aut In Фармацевтичний журнал The State Expert Center of the Ministry of Health of Ukraine, 2019 3(2019), 3, Seite 49-55 (DE-627)1760619841 26179628 nnns volume:3 year:2019 number:3 pages:49-55 https://doi.org/10.32352/0367-3057.3.19.06 kostenfrei https://doaj.org/article/1d4c940437fe4c35bf5a953db40b3a88 kostenfrei https://pharmj.org.ua/index.php/journal/article/view/604/569 kostenfrei https://doaj.org/toc/0367-3057 Journal toc kostenfrei https://doaj.org/toc/2617-9628 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2019 3 49-55 |
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10.32352/0367-3057.3.19.06 doi (DE-627)DOAJ029778395 (DE-599)DOAJ1d4c940437fe4c35bf5a953db40b3a88 DE-627 ger DE-627 rakwb ukr RM1-950 RS1-441 Yu. S. Maslii verfasserin aut Justification of local anesthetic and choice of its concentration in composition of dental gel 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. dental gel lidocaine hydrochloride local anesthetic activity Therapeutics. Pharmacology Pharmacy and materia medica O. О. Hrudnytska verfasserin aut O. A. Ruban verfasserin aut G. V. Zaychenko verfasserin aut In Фармацевтичний журнал The State Expert Center of the Ministry of Health of Ukraine, 2019 3(2019), 3, Seite 49-55 (DE-627)1760619841 26179628 nnns volume:3 year:2019 number:3 pages:49-55 https://doi.org/10.32352/0367-3057.3.19.06 kostenfrei https://doaj.org/article/1d4c940437fe4c35bf5a953db40b3a88 kostenfrei https://pharmj.org.ua/index.php/journal/article/view/604/569 kostenfrei https://doaj.org/toc/0367-3057 Journal toc kostenfrei https://doaj.org/toc/2617-9628 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2019 3 49-55 |
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10.32352/0367-3057.3.19.06 doi (DE-627)DOAJ029778395 (DE-599)DOAJ1d4c940437fe4c35bf5a953db40b3a88 DE-627 ger DE-627 rakwb ukr RM1-950 RS1-441 Yu. S. Maslii verfasserin aut Justification of local anesthetic and choice of its concentration in composition of dental gel 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. dental gel lidocaine hydrochloride local anesthetic activity Therapeutics. Pharmacology Pharmacy and materia medica O. О. Hrudnytska verfasserin aut O. A. Ruban verfasserin aut G. V. Zaychenko verfasserin aut In Фармацевтичний журнал The State Expert Center of the Ministry of Health of Ukraine, 2019 3(2019), 3, Seite 49-55 (DE-627)1760619841 26179628 nnns volume:3 year:2019 number:3 pages:49-55 https://doi.org/10.32352/0367-3057.3.19.06 kostenfrei https://doaj.org/article/1d4c940437fe4c35bf5a953db40b3a88 kostenfrei https://pharmj.org.ua/index.php/journal/article/view/604/569 kostenfrei https://doaj.org/toc/0367-3057 Journal toc kostenfrei https://doaj.org/toc/2617-9628 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2019 3 49-55 |
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10.32352/0367-3057.3.19.06 doi (DE-627)DOAJ029778395 (DE-599)DOAJ1d4c940437fe4c35bf5a953db40b3a88 DE-627 ger DE-627 rakwb ukr RM1-950 RS1-441 Yu. S. Maslii verfasserin aut Justification of local anesthetic and choice of its concentration in composition of dental gel 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. dental gel lidocaine hydrochloride local anesthetic activity Therapeutics. Pharmacology Pharmacy and materia medica O. О. Hrudnytska verfasserin aut O. A. Ruban verfasserin aut G. V. Zaychenko verfasserin aut In Фармацевтичний журнал The State Expert Center of the Ministry of Health of Ukraine, 2019 3(2019), 3, Seite 49-55 (DE-627)1760619841 26179628 nnns volume:3 year:2019 number:3 pages:49-55 https://doi.org/10.32352/0367-3057.3.19.06 kostenfrei https://doaj.org/article/1d4c940437fe4c35bf5a953db40b3a88 kostenfrei https://pharmj.org.ua/index.php/journal/article/view/604/569 kostenfrei https://doaj.org/toc/0367-3057 Journal toc kostenfrei https://doaj.org/toc/2617-9628 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2019 3 49-55 |
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10.32352/0367-3057.3.19.06 doi (DE-627)DOAJ029778395 (DE-599)DOAJ1d4c940437fe4c35bf5a953db40b3a88 DE-627 ger DE-627 rakwb ukr RM1-950 RS1-441 Yu. S. Maslii verfasserin aut Justification of local anesthetic and choice of its concentration in composition of dental gel 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. dental gel lidocaine hydrochloride local anesthetic activity Therapeutics. Pharmacology Pharmacy and materia medica O. О. Hrudnytska verfasserin aut O. A. Ruban verfasserin aut G. V. Zaychenko verfasserin aut In Фармацевтичний журнал The State Expert Center of the Ministry of Health of Ukraine, 2019 3(2019), 3, Seite 49-55 (DE-627)1760619841 26179628 nnns volume:3 year:2019 number:3 pages:49-55 https://doi.org/10.32352/0367-3057.3.19.06 kostenfrei https://doaj.org/article/1d4c940437fe4c35bf5a953db40b3a88 kostenfrei https://pharmj.org.ua/index.php/journal/article/view/604/569 kostenfrei https://doaj.org/toc/0367-3057 Journal toc kostenfrei https://doaj.org/toc/2617-9628 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2019 3 49-55 |
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Justification of local anesthetic and choice of its concentration in composition of dental gel |
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Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. |
| abstractGer |
Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. |
| abstract_unstemmed |
Dental diseases are often accompanied by painful sensations, so usually symptomatic treatment of these pathologies includes local anesthetics, as which we have selected anesthetic of local action – lidocaine hydrochloride. The aim of the research is to substantiate the rational concentration of lidocaine hydrochloride in the composition of the dental gel being developed by pharmacological screening of its model samples. The object of the study is dental gel with tincture "Phytodent" (PJSC “CPP “Red Star”, Ukraine), choline salicylate 80% (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy). The anesthetic was injected into the gel at various concentrations – 1.0%, 1.5% and 2.0%. The study of local anesthetic/analgesic activity of gel test samples was performed by the Randall-Selitto method using an electronic Pressure Analgesiometer (IITC Life Science, USA). The study was conducted on male rats weighing 190–210 g. The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect. |
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The animals were divided into three groups: animals of the 1st group were applied with 2.0% lidocaine hydrochloride gel (sample number 1), the second group – with 1.5% concentration (sample number 2), the third group – with 1.0% lidocaine content (sample number 3). The animal was held in the hands of a researcher, its limb was placed in analgesiometer. Determined the force of pressure in grams, which causes the reaction of the paw pull back / squeal in response to a painful stimulus. Analgesic activity was studied on the model of kaolin edema, which was simulated by sub-planar introduction of kaolin solution (10 mg/ml) in the amount of 0.1 ml/100 grams of body weight (administration under the aponeurosis of the posterior paw). In animals, the initial pain sensitivity was evaluated 1 hour after the introduction of the phlogogenic agent, after which the gel was applied to the foot, and in 1 hour 15 minutes, 1 hour 30 minutes and 2 hours after the exudative edema modelling. Calculated the percentage of change to the initial threshold of tactile sensitivity, as well as the percentage of change to the level of algesia (pain response) 1 hour after the introduction of the phlogogenic agent. Statistical processing of the data was performed using Student's t-criterion. According to the results, pronounced pain syndrome was detected in animals of all three groups 1 hour after the introduction of the phlogogenic agent. The use of gel with 1.0% concentration of lidocaine hydrochloride did not show a significant antinociceptive effect and could be considered as a tendency for analgesia. The pronounced local anesthetic effect was observed with the use of gel test specimens with the anesthetic concentrations of 1.5% and 2.0% after 15 and 30 minutes and lasted for at least 2 hours. The drug developed was compared with the dental gel “Kamistad®” (Stada Arzneimittel AG, Germany), which also contains lidocaine hydrochloride in an amount of 2.0%. Taking into account the fact that reliable statistical differences in the severity of analgesic activity between the test samples of gel number 1 and number 2 were not detected, it can be argued that lower lidocaine concentration 1.5% in the composition of the developed dental gel can be used. In addition, the claimed dental gel exceeded the referent drug "Kamistad®" (Stada Arzneimittel AG, Germany) by the expressiveness of antinociceptive effect.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">dental gel</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lidocaine hydrochloride</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">local anesthetic activity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pharmacy and materia medica</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">O. О. Hrudnytska</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">O. A. Ruban</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">G. V. Zaychenko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Фармацевтичний журнал</subfield><subfield code="d">The State Expert Center of the Ministry of Health of Ukraine, 2019</subfield><subfield code="g">3(2019), 3, Seite 49-55</subfield><subfield code="w">(DE-627)1760619841</subfield><subfield code="x">26179628</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:49-55</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.32352/0367-3057.3.19.06</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/1d4c940437fe4c35bf5a953db40b3a88</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://pharmj.org.ua/index.php/journal/article/view/604/569</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/0367-3057</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2617-9628</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2019</subfield><subfield code="e">3</subfield><subfield code="h">49-55</subfield></datafield></record></collection>
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