Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries

The plasticizer bisphenol A, a typical endocrine disrupting chemical, is widely present in the environment. Previous studies demonstrated that exposure to bisphenol A can cause reproductive toxicity, abnormal fertilization, and infertility. However, the mechanisms of low-concentration bisphenol A on...
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Gespeichert in:

Autor*in:	Xiaoxin Dai [verfasserIn] Lijun Qiu [verfasserIn] Han Zhang [verfasserIn] Chunying Xu [verfasserIn] Bo Zhao [verfasserIn] Yang Gao [verfasserIn] Haidong Li [verfasserIn] Yi Mu [verfasserIn] Zhangjie Chu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	zebrafish bisphenol A tea polyphenols transcriptome mitochondrial NADH dehydrogenase

Übergeordnetes Werk:	In: Frontiers in Marine Science - Frontiers Media S.A., 2015, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmars.2022.915415

Katalog-ID:	DOAJ029804280

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topic_facet	zebrafish bisphenol A tea polyphenols transcriptome mitochondrial NADH dehydrogenase Science Q General. Including nature conservation, geographical distribution
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container_title	Frontiers in Marine Science
authorswithroles_txt_mv	Xiaoxin Dai @@aut@@ Lijun Qiu @@aut@@ Han Zhang @@aut@@ Chunying Xu @@aut@@ Bo Zhao @@aut@@ Yang Gao @@aut@@ Haidong Li @@aut@@ Yi Mu @@aut@@ Zhangjie Chu @@aut@@
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callnumber-first	Q - Science
author	Xiaoxin Dai
spellingShingle	Xiaoxin Dai misc QH1-199.5 misc zebrafish misc bisphenol A misc tea polyphenols misc transcriptome misc mitochondrial NADH dehydrogenase misc Science misc Q misc General. Including nature conservation, geographical distribution Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries
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topic_title	QH1-199.5 Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries zebrafish bisphenol A tea polyphenols transcriptome mitochondrial NADH dehydrogenase
topic	misc QH1-199.5 misc zebrafish misc bisphenol A misc tea polyphenols misc transcriptome misc mitochondrial NADH dehydrogenase misc Science misc Q misc General. Including nature conservation, geographical distribution
topic_unstemmed	misc QH1-199.5 misc zebrafish misc bisphenol A misc tea polyphenols misc transcriptome misc mitochondrial NADH dehydrogenase misc Science misc Q misc General. Including nature conservation, geographical distribution
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title	Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries
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title_full	Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries
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title_sort	tea polyphenols improve down-regulation of mitochondrial functional gene expression induced by bisphenol a in zebrafish ovaries
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title_auth	Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries
abstract	The plasticizer bisphenol A, a typical endocrine disrupting chemical, is widely present in the environment. Previous studies demonstrated that exposure to bisphenol A can cause reproductive toxicity, abnormal fertilization, and infertility. However, the mechanisms of low-concentration bisphenol A on the reproductive system and treatment measures have not been fully determined. In this study, we explored the transcriptomic profiles of female zebrafish ovaries. The transcriptomic data revealed that mitochondrial NADH dehydrogenase (mt-Nd) genes were significantly decreased in the bisphenol A-exposed group, while the co-administration of tea polyphenols remarkably elevated the expression of mt-Nd genes. To further explore the expression pattern of the mt-Nd, we analyzed the expression of six mt-Nd genes on different days by qRT-PCR in control, bisphenol A-exposed, and bisphenol A-tea polyphenols ovaries. Here, we found that 0.1 mg/L bisphenol A exposure adversely affects the mitochondrial respiratory chain in ovaries and may lead to reproductive disorders. Finally, our study demonstrated that tea polyphenols play a protective role in ovarian mitochondrial dysfunction in low-concentration bisphenol A-exposed female zebrafish.
abstractGer	The plasticizer bisphenol A, a typical endocrine disrupting chemical, is widely present in the environment. Previous studies demonstrated that exposure to bisphenol A can cause reproductive toxicity, abnormal fertilization, and infertility. However, the mechanisms of low-concentration bisphenol A on the reproductive system and treatment measures have not been fully determined. In this study, we explored the transcriptomic profiles of female zebrafish ovaries. The transcriptomic data revealed that mitochondrial NADH dehydrogenase (mt-Nd) genes were significantly decreased in the bisphenol A-exposed group, while the co-administration of tea polyphenols remarkably elevated the expression of mt-Nd genes. To further explore the expression pattern of the mt-Nd, we analyzed the expression of six mt-Nd genes on different days by qRT-PCR in control, bisphenol A-exposed, and bisphenol A-tea polyphenols ovaries. Here, we found that 0.1 mg/L bisphenol A exposure adversely affects the mitochondrial respiratory chain in ovaries and may lead to reproductive disorders. Finally, our study demonstrated that tea polyphenols play a protective role in ovarian mitochondrial dysfunction in low-concentration bisphenol A-exposed female zebrafish.
abstract_unstemmed	The plasticizer bisphenol A, a typical endocrine disrupting chemical, is widely present in the environment. Previous studies demonstrated that exposure to bisphenol A can cause reproductive toxicity, abnormal fertilization, and infertility. However, the mechanisms of low-concentration bisphenol A on the reproductive system and treatment measures have not been fully determined. In this study, we explored the transcriptomic profiles of female zebrafish ovaries. The transcriptomic data revealed that mitochondrial NADH dehydrogenase (mt-Nd) genes were significantly decreased in the bisphenol A-exposed group, while the co-administration of tea polyphenols remarkably elevated the expression of mt-Nd genes. To further explore the expression pattern of the mt-Nd, we analyzed the expression of six mt-Nd genes on different days by qRT-PCR in control, bisphenol A-exposed, and bisphenol A-tea polyphenols ovaries. Here, we found that 0.1 mg/L bisphenol A exposure adversely affects the mitochondrial respiratory chain in ovaries and may lead to reproductive disorders. Finally, our study demonstrated that tea polyphenols play a protective role in ovarian mitochondrial dysfunction in low-concentration bisphenol A-exposed female zebrafish.
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title_short	Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries
url	https://doi.org/10.3389/fmars.2022.915415 https://doaj.org/article/03074940d5e8404fb7dd97bc66c2c23c https://www.frontiersin.org/articles/10.3389/fmars.2022.915415/full https://doaj.org/toc/2296-7745
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up_date	2024-07-04T00:28:00.821Z
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Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries

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