Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids

The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived p...
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Autor*in:	Kate Firipis [verfasserIn] Elizabeth Footner [verfasserIn] Mitchell Boyd-Moss [verfasserIn] Chaitali Dekiwadia [verfasserIn] David Nisbet [verfasserIn] Robert MI. Kapsa [verfasserIn] Elena Pirogova [verfasserIn] Richard J. Williams [verfasserIn] Anita Quigley [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials

Übergeordnetes Werk:	In: Materials Today Advances - Elsevier, 2019, 14(2022), Seite 100243-
Übergeordnetes Werk:	volume:14 ; year:2022 ; pages:100243-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.mtadv.2022.100243

Katalog-ID:	DOAJ029856868

Internformat


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allfields	10.1016/j.mtadv.2022.100243 doi (DE-627)DOAJ029856868 (DE-599)DOAJc74d9cdbc3b7426db4a630020c889d0f DE-627 ger DE-627 rakwb eng TA401-492 Kate Firipis verfasserin aut Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material. Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials Materials of engineering and construction. Mechanics of materials Elizabeth Footner verfasserin aut Mitchell Boyd-Moss verfasserin aut Chaitali Dekiwadia verfasserin aut David Nisbet verfasserin aut Robert MI. Kapsa verfasserin aut Elena Pirogova verfasserin aut Richard J. Williams verfasserin aut Anita Quigley verfasserin aut In Materials Today Advances Elsevier, 2019 14(2022), Seite 100243- (DE-627)1668131951 25900498 nnns volume:14 year:2022 pages:100243- https://doi.org/10.1016/j.mtadv.2022.100243 kostenfrei https://doaj.org/article/c74d9cdbc3b7426db4a630020c889d0f kostenfrei http://www.sciencedirect.com/science/article/pii/S259004982200039X kostenfrei https://doaj.org/toc/2590-0498 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2022 100243-
spelling	10.1016/j.mtadv.2022.100243 doi (DE-627)DOAJ029856868 (DE-599)DOAJc74d9cdbc3b7426db4a630020c889d0f DE-627 ger DE-627 rakwb eng TA401-492 Kate Firipis verfasserin aut Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material. Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials Materials of engineering and construction. Mechanics of materials Elizabeth Footner verfasserin aut Mitchell Boyd-Moss verfasserin aut Chaitali Dekiwadia verfasserin aut David Nisbet verfasserin aut Robert MI. Kapsa verfasserin aut Elena Pirogova verfasserin aut Richard J. Williams verfasserin aut Anita Quigley verfasserin aut In Materials Today Advances Elsevier, 2019 14(2022), Seite 100243- (DE-627)1668131951 25900498 nnns volume:14 year:2022 pages:100243- https://doi.org/10.1016/j.mtadv.2022.100243 kostenfrei https://doaj.org/article/c74d9cdbc3b7426db4a630020c889d0f kostenfrei http://www.sciencedirect.com/science/article/pii/S259004982200039X kostenfrei https://doaj.org/toc/2590-0498 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2022 100243-
allfields_unstemmed	10.1016/j.mtadv.2022.100243 doi (DE-627)DOAJ029856868 (DE-599)DOAJc74d9cdbc3b7426db4a630020c889d0f DE-627 ger DE-627 rakwb eng TA401-492 Kate Firipis verfasserin aut Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material. Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials Materials of engineering and construction. Mechanics of materials Elizabeth Footner verfasserin aut Mitchell Boyd-Moss verfasserin aut Chaitali Dekiwadia verfasserin aut David Nisbet verfasserin aut Robert MI. Kapsa verfasserin aut Elena Pirogova verfasserin aut Richard J. Williams verfasserin aut Anita Quigley verfasserin aut In Materials Today Advances Elsevier, 2019 14(2022), Seite 100243- (DE-627)1668131951 25900498 nnns volume:14 year:2022 pages:100243- https://doi.org/10.1016/j.mtadv.2022.100243 kostenfrei https://doaj.org/article/c74d9cdbc3b7426db4a630020c889d0f kostenfrei http://www.sciencedirect.com/science/article/pii/S259004982200039X kostenfrei https://doaj.org/toc/2590-0498 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2022 100243-
allfieldsGer	10.1016/j.mtadv.2022.100243 doi (DE-627)DOAJ029856868 (DE-599)DOAJc74d9cdbc3b7426db4a630020c889d0f DE-627 ger DE-627 rakwb eng TA401-492 Kate Firipis verfasserin aut Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material. Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials Materials of engineering and construction. Mechanics of materials Elizabeth Footner verfasserin aut Mitchell Boyd-Moss verfasserin aut Chaitali Dekiwadia verfasserin aut David Nisbet verfasserin aut Robert MI. Kapsa verfasserin aut Elena Pirogova verfasserin aut Richard J. Williams verfasserin aut Anita Quigley verfasserin aut In Materials Today Advances Elsevier, 2019 14(2022), Seite 100243- (DE-627)1668131951 25900498 nnns volume:14 year:2022 pages:100243- https://doi.org/10.1016/j.mtadv.2022.100243 kostenfrei https://doaj.org/article/c74d9cdbc3b7426db4a630020c889d0f kostenfrei http://www.sciencedirect.com/science/article/pii/S259004982200039X kostenfrei https://doaj.org/toc/2590-0498 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2022 100243-
allfieldsSound	10.1016/j.mtadv.2022.100243 doi (DE-627)DOAJ029856868 (DE-599)DOAJc74d9cdbc3b7426db4a630020c889d0f DE-627 ger DE-627 rakwb eng TA401-492 Kate Firipis verfasserin aut Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material. Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials Materials of engineering and construction. Mechanics of materials Elizabeth Footner verfasserin aut Mitchell Boyd-Moss verfasserin aut Chaitali Dekiwadia verfasserin aut David Nisbet verfasserin aut Robert MI. Kapsa verfasserin aut Elena Pirogova verfasserin aut Richard J. Williams verfasserin aut Anita Quigley verfasserin aut In Materials Today Advances Elsevier, 2019 14(2022), Seite 100243- (DE-627)1668131951 25900498 nnns volume:14 year:2022 pages:100243- https://doi.org/10.1016/j.mtadv.2022.100243 kostenfrei https://doaj.org/article/c74d9cdbc3b7426db4a630020c889d0f kostenfrei http://www.sciencedirect.com/science/article/pii/S259004982200039X kostenfrei https://doaj.org/toc/2590-0498 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2022 100243-
language	English
source	In Materials Today Advances 14(2022), Seite 100243- volume:14 year:2022 pages:100243-
sourceStr	In Materials Today Advances 14(2022), Seite 100243- volume:14 year:2022 pages:100243-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials Materials of engineering and construction. Mechanics of materials
isfreeaccess_bool	true
container_title	Materials Today Advances
authorswithroles_txt_mv	Kate Firipis @@aut@@ Elizabeth Footner @@aut@@ Mitchell Boyd-Moss @@aut@@ Chaitali Dekiwadia @@aut@@ David Nisbet @@aut@@ Robert MI. Kapsa @@aut@@ Elena Pirogova @@aut@@ Richard J. Williams @@aut@@ Anita Quigley @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	1668131951
id	DOAJ029856868
language_de	englisch
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callnumber-first	T - Technology
author	Kate Firipis
spellingShingle	Kate Firipis misc TA401-492 misc Self-assembling peptides misc Bioinks misc Biofabrication misc Polysaccharide misc Hybrid materials misc Materials of engineering and construction. Mechanics of materials Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids
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topic_title	TA401-492 Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids Self-assembling peptides Bioinks Biofabrication Polysaccharide Hybrid materials
topic	misc TA401-492 misc Self-assembling peptides misc Bioinks misc Biofabrication misc Polysaccharide misc Hybrid materials misc Materials of engineering and construction. Mechanics of materials
topic_unstemmed	misc TA401-492 misc Self-assembling peptides misc Bioinks misc Biofabrication misc Polysaccharide misc Hybrid materials misc Materials of engineering and construction. Mechanics of materials
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title	Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids
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title_full	Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids
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title_sort	biodesigned bioinks for 3d printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids
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title_auth	Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids
abstract	The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material.
abstractGer	The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material.
abstract_unstemmed	The demands of tissue engineering and regenerative medicine require biomaterials to be accurately deposited into biomimetic shapes, support cellular behaviour and lead to functional tissue formation. Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material.
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title_short	Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids
url	https://doi.org/10.1016/j.mtadv.2022.100243 https://doaj.org/article/c74d9cdbc3b7426db4a630020c889d0f http://www.sciencedirect.com/science/article/pii/S259004982200039X https://doaj.org/toc/2590-0498
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Bioinspired yet synthetic biomaterials offer significant advantages over processed, animal-derived products; including high reproducibility and clinical compliance and specific engineered biomimicry of architecture and biological function. Self-assembling peptides are synthetic highly hydrated scaffolds that are rationally designed to mimic the extracellular matrix of a target tissue. Due to the potential benefits of chemically synthesised self-assembling peptides for clinical translation, their development into tools for biofabrication is warranted. However, these systems can be poorly suited to the demands of biofabrication, particularly when functionalised toward tissue-specific conditions. Here, we demonstrate how to improve biofabrication of self-assembling peptides. The fibrillar network arising from the self-assembling peptide Fmoc-FRGDF (containing cell attachment motif RGD) is combined with the robust polysaccharides agarose and alginate demonstrating enhanced printability and cellular compatibility. This study provides a robust methodology for the on-demand printing of personalised implants with a clinically relevant material.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Self-assembling peptides</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bioinks</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biofabrication</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polysaccharide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hybrid materials</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Materials of engineering and construction. Mechanics of materials</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth Footner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mitchell Boyd-Moss</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chaitali Dekiwadia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Nisbet</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robert MI. Kapsa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elena Pirogova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Richard J. Williams</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anita Quigley</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Materials Today Advances</subfield><subfield code="d">Elsevier, 2019</subfield><subfield code="g">14(2022), Seite 100243-</subfield><subfield code="w">(DE-627)1668131951</subfield><subfield code="x">25900498</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:14</subfield><subfield code="g">year:2022</subfield><subfield code="g">pages:100243-</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.mtadv.2022.100243</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" 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Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids

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