Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion

Cannabidiol (CBD) is a non-psychoactive cannabinoid compound found in hemp plants that has recently sparked interest in the biomedical and food industries. CBD is a natural decarboxylated product of cannabidiolic acid (CBDA). In this study, processing parameters were developed to enhance the decarbo...
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Autor*in:	Md Obyedul Kalam Azad [verfasserIn] Byeong Ryeol Ryu [verfasserIn] Md Soyel Rana [verfasserIn] Md Hafizur Rahman [verfasserIn] Jung-Dae Lim [verfasserIn] Young-Seok Lim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	biopolymer formulation decarboxylation bioactive compounds antioxidant capacity

Übergeordnetes Werk:	In: Processes - MDPI AG, 2013, 9(2021), 837, p 837
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:837, p 837

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pr9050837

Katalog-ID:	DOAJ029887003

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callnumber-first	T - Technology
author	Md Obyedul Kalam Azad
spellingShingle	Md Obyedul Kalam Azad misc TP1-1185 misc QD1-999 misc biopolymer misc formulation misc decarboxylation misc bioactive compounds misc antioxidant capacity misc Chemical technology misc Chemistry Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion
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topic_title	TP1-1185 QD1-999 Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion biopolymer formulation decarboxylation bioactive compounds antioxidant capacity
topic	misc TP1-1185 misc QD1-999 misc biopolymer misc formulation misc decarboxylation misc bioactive compounds misc antioxidant capacity misc Chemical technology misc Chemistry
topic_unstemmed	misc TP1-1185 misc QD1-999 misc biopolymer misc formulation misc decarboxylation misc bioactive compounds misc antioxidant capacity misc Chemical technology misc Chemistry
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title	Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion
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title_full	Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion
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author_browse	Md Obyedul Kalam Azad Byeong Ryeol Ryu Md Soyel Rana Md Hafizur Rahman Jung-Dae Lim Young-Seok Lim
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title_sort	enhancing the cannabidiol (cbd) compound in formulated hemp (<i<cannabis sativa</i< l.) leaves through the application of hot-melt extrusion
callnumber	TP1-1185
title_auth	Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion
abstract	Cannabidiol (CBD) is a non-psychoactive cannabinoid compound found in hemp plants that has recently sparked interest in the biomedical and food industries. CBD is a natural decarboxylated product of cannabidiolic acid (CBDA). In this study, processing parameters were developed to enhance the decarboxylation process of CBDA in hemp leaves using hot-melt extrusion (HME). The hemp leaves were formulated with two different acid-based polymers, namely ascorbic acid (AA) and ascorbyl palmitate (AP), before the HME. The results showed that the carboxylation process of CBDA was increased by at least 2.5 times in the extrudate leaves and the content of the CBD was four times higher when formulated with AP (2800 µg/g) compared with the raw leaves (736 µg/g). The total phenolic and total flavonoid content, as well as the DPPH antioxidant capacity, were higher in the AP formulated extrudate. At the same time, the Δ9-tetrahydrocannabinol (THC) content was reduced by half in the extrudate compared with the raw leaves. It was also observed that double HME processing did not increase the decarboxylation process. It was concluded that the HME process significantly improved the conversion rate of CBDA to CBD in formulated hemp leaves with a reduced THC content.
abstractGer	Cannabidiol (CBD) is a non-psychoactive cannabinoid compound found in hemp plants that has recently sparked interest in the biomedical and food industries. CBD is a natural decarboxylated product of cannabidiolic acid (CBDA). In this study, processing parameters were developed to enhance the decarboxylation process of CBDA in hemp leaves using hot-melt extrusion (HME). The hemp leaves were formulated with two different acid-based polymers, namely ascorbic acid (AA) and ascorbyl palmitate (AP), before the HME. The results showed that the carboxylation process of CBDA was increased by at least 2.5 times in the extrudate leaves and the content of the CBD was four times higher when formulated with AP (2800 µg/g) compared with the raw leaves (736 µg/g). The total phenolic and total flavonoid content, as well as the DPPH antioxidant capacity, were higher in the AP formulated extrudate. At the same time, the Δ9-tetrahydrocannabinol (THC) content was reduced by half in the extrudate compared with the raw leaves. It was also observed that double HME processing did not increase the decarboxylation process. It was concluded that the HME process significantly improved the conversion rate of CBDA to CBD in formulated hemp leaves with a reduced THC content.
abstract_unstemmed	Cannabidiol (CBD) is a non-psychoactive cannabinoid compound found in hemp plants that has recently sparked interest in the biomedical and food industries. CBD is a natural decarboxylated product of cannabidiolic acid (CBDA). In this study, processing parameters were developed to enhance the decarboxylation process of CBDA in hemp leaves using hot-melt extrusion (HME). The hemp leaves were formulated with two different acid-based polymers, namely ascorbic acid (AA) and ascorbyl palmitate (AP), before the HME. The results showed that the carboxylation process of CBDA was increased by at least 2.5 times in the extrudate leaves and the content of the CBD was four times higher when formulated with AP (2800 µg/g) compared with the raw leaves (736 µg/g). The total phenolic and total flavonoid content, as well as the DPPH antioxidant capacity, were higher in the AP formulated extrudate. At the same time, the Δ9-tetrahydrocannabinol (THC) content was reduced by half in the extrudate compared with the raw leaves. It was also observed that double HME processing did not increase the decarboxylation process. It was concluded that the HME process significantly improved the conversion rate of CBDA to CBD in formulated hemp leaves with a reduced THC content.
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title_short	Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion
url	https://doi.org/10.3390/pr9050837 https://doaj.org/article/197b2b4b7c584ade99cdc01ff4fcddf0 https://www.mdpi.com/2227-9717/9/5/837 https://doaj.org/toc/2227-9717
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author2	Byeong Ryeol Ryu Md Soyel Rana Md Hafizur Rahman Jung-Dae Lim Young-Seok Lim
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up_date	2024-07-04T00:47:59.790Z
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Enhancing the Cannabidiol (CBD) Compound in Formulated Hemp (<i<Cannabis sativa</i< L.) Leaves through the Application of Hot-Melt Extrusion

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