Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages

Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) i...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Laura Unverdorben [verfasserIn] Thomas Haufe [verfasserIn] Laura Santoso [verfasserIn] Simone Hofmann [verfasserIn] Udo Jeschke [verfasserIn] Stefan Hutter [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	galectins placenta trophoblast decidua spontaneous and recurrent miscarriage

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 17(2016), 5, p 644
Übergeordnetes Werk:	volume:17 ; year:2016 ; number:5, p 644

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms17050644

Katalog-ID:	DOAJ029927382

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allfields	10.3390/ijms17050644 doi (DE-627)DOAJ029927382 (DE-599)DOAJ92c0bebf5fa24e71adace8f1ba49b3dd DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Unverdorben verfasserin aut Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas. galectins placenta trophoblast decidua spontaneous and recurrent miscarriage Biology (General) Chemistry Thomas Haufe verfasserin aut Laura Santoso verfasserin aut Simone Hofmann verfasserin aut Udo Jeschke verfasserin aut Stefan Hutter verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 17(2016), 5, p 644 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:17 year:2016 number:5, p 644 https://doi.org/10.3390/ijms17050644 kostenfrei https://doaj.org/article/92c0bebf5fa24e71adace8f1ba49b3dd kostenfrei http://www.mdpi.com/1422-0067/17/5/644 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2016 5, p 644
spelling	10.3390/ijms17050644 doi (DE-627)DOAJ029927382 (DE-599)DOAJ92c0bebf5fa24e71adace8f1ba49b3dd DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Unverdorben verfasserin aut Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas. galectins placenta trophoblast decidua spontaneous and recurrent miscarriage Biology (General) Chemistry Thomas Haufe verfasserin aut Laura Santoso verfasserin aut Simone Hofmann verfasserin aut Udo Jeschke verfasserin aut Stefan Hutter verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 17(2016), 5, p 644 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:17 year:2016 number:5, p 644 https://doi.org/10.3390/ijms17050644 kostenfrei https://doaj.org/article/92c0bebf5fa24e71adace8f1ba49b3dd kostenfrei http://www.mdpi.com/1422-0067/17/5/644 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2016 5, p 644
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allfieldsSound	10.3390/ijms17050644 doi (DE-627)DOAJ029927382 (DE-599)DOAJ92c0bebf5fa24e71adace8f1ba49b3dd DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Unverdorben verfasserin aut Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas. galectins placenta trophoblast decidua spontaneous and recurrent miscarriage Biology (General) Chemistry Thomas Haufe verfasserin aut Laura Santoso verfasserin aut Simone Hofmann verfasserin aut Udo Jeschke verfasserin aut Stefan Hutter verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 17(2016), 5, p 644 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:17 year:2016 number:5, p 644 https://doi.org/10.3390/ijms17050644 kostenfrei https://doaj.org/article/92c0bebf5fa24e71adace8f1ba49b3dd kostenfrei http://www.mdpi.com/1422-0067/17/5/644 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2016 5, p 644
language	English
source	In International Journal of Molecular Sciences 17(2016), 5, p 644 volume:17 year:2016 number:5, p 644
sourceStr	In International Journal of Molecular Sciences 17(2016), 5, p 644 volume:17 year:2016 number:5, p 644
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	galectins placenta trophoblast decidua spontaneous and recurrent miscarriage Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Laura Unverdorben @@aut@@ Thomas Haufe @@aut@@ Laura Santoso @@aut@@ Simone Hofmann @@aut@@ Udo Jeschke @@aut@@ Stefan Hutter @@aut@@
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callnumber-first	Q - Science
author	Laura Unverdorben
spellingShingle	Laura Unverdorben misc QH301-705.5 misc QD1-999 misc galectins misc placenta misc trophoblast misc decidua misc spontaneous and recurrent miscarriage misc Biology (General) misc Chemistry Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
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topic_title	QH301-705.5 QD1-999 Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages galectins placenta trophoblast decidua spontaneous and recurrent miscarriage
topic	misc QH301-705.5 misc QD1-999 misc galectins misc placenta misc trophoblast misc decidua misc spontaneous and recurrent miscarriage misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc galectins misc placenta misc trophoblast misc decidua misc spontaneous and recurrent miscarriage misc Biology (General) misc Chemistry
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title	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
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title_full	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
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title_sort	prototype and chimera-type galectins in placentas with spontaneous and recurrent miscarriages
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title_auth	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
abstract	Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.
abstractGer	Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.
abstract_unstemmed	Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.
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title_short	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
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up_date	2024-07-04T00:57:07.806Z
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We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. 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Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages

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