Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC

Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with inst...
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Autor*in:	Ryo Tanifuji [verfasserIn] Naoto Haraguchi [verfasserIn] Hiroki Oguri [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis

Übergeordnetes Werk:	In: Tetrahedron Chem - Elsevier, 2022, 1(2022), Seite 100010-
Übergeordnetes Werk:	volume:1 ; year:2022 ; pages:100010-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.tchem.2022.100010

Katalog-ID:	DOAJ029956773

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publishDate	2022
allfields	10.1016/j.tchem.2022.100010 doi (DE-627)DOAJ029956773 (DE-599)DOAJe22ed92458ef4d5c93cca856ac4db42a DE-627 ger DE-627 rakwb eng QD241-441 Ryo Tanifuji verfasserin aut Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives. Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis Organic chemistry Naoto Haraguchi verfasserin aut Hiroki Oguri verfasserin aut In Tetrahedron Chem Elsevier, 2022 1(2022), Seite 100010- (DE-627)178621475X 2666951X nnns volume:1 year:2022 pages:100010- https://doi.org/10.1016/j.tchem.2022.100010 kostenfrei https://doaj.org/article/e22ed92458ef4d5c93cca856ac4db42a kostenfrei http://www.sciencedirect.com/science/article/pii/S2666951X22000067 kostenfrei https://doaj.org/toc/2666-951X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2022 100010-
spelling	10.1016/j.tchem.2022.100010 doi (DE-627)DOAJ029956773 (DE-599)DOAJe22ed92458ef4d5c93cca856ac4db42a DE-627 ger DE-627 rakwb eng QD241-441 Ryo Tanifuji verfasserin aut Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives. Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis Organic chemistry Naoto Haraguchi verfasserin aut Hiroki Oguri verfasserin aut In Tetrahedron Chem Elsevier, 2022 1(2022), Seite 100010- (DE-627)178621475X 2666951X nnns volume:1 year:2022 pages:100010- https://doi.org/10.1016/j.tchem.2022.100010 kostenfrei https://doaj.org/article/e22ed92458ef4d5c93cca856ac4db42a kostenfrei http://www.sciencedirect.com/science/article/pii/S2666951X22000067 kostenfrei https://doaj.org/toc/2666-951X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2022 100010-
allfields_unstemmed	10.1016/j.tchem.2022.100010 doi (DE-627)DOAJ029956773 (DE-599)DOAJe22ed92458ef4d5c93cca856ac4db42a DE-627 ger DE-627 rakwb eng QD241-441 Ryo Tanifuji verfasserin aut Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives. Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis Organic chemistry Naoto Haraguchi verfasserin aut Hiroki Oguri verfasserin aut In Tetrahedron Chem Elsevier, 2022 1(2022), Seite 100010- (DE-627)178621475X 2666951X nnns volume:1 year:2022 pages:100010- https://doi.org/10.1016/j.tchem.2022.100010 kostenfrei https://doaj.org/article/e22ed92458ef4d5c93cca856ac4db42a kostenfrei http://www.sciencedirect.com/science/article/pii/S2666951X22000067 kostenfrei https://doaj.org/toc/2666-951X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2022 100010-
allfieldsGer	10.1016/j.tchem.2022.100010 doi (DE-627)DOAJ029956773 (DE-599)DOAJe22ed92458ef4d5c93cca856ac4db42a DE-627 ger DE-627 rakwb eng QD241-441 Ryo Tanifuji verfasserin aut Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives. Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis Organic chemistry Naoto Haraguchi verfasserin aut Hiroki Oguri verfasserin aut In Tetrahedron Chem Elsevier, 2022 1(2022), Seite 100010- (DE-627)178621475X 2666951X nnns volume:1 year:2022 pages:100010- https://doi.org/10.1016/j.tchem.2022.100010 kostenfrei https://doaj.org/article/e22ed92458ef4d5c93cca856ac4db42a kostenfrei http://www.sciencedirect.com/science/article/pii/S2666951X22000067 kostenfrei https://doaj.org/toc/2666-951X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2022 100010-
allfieldsSound	10.1016/j.tchem.2022.100010 doi (DE-627)DOAJ029956773 (DE-599)DOAJe22ed92458ef4d5c93cca856ac4db42a DE-627 ger DE-627 rakwb eng QD241-441 Ryo Tanifuji verfasserin aut Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives. Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis Organic chemistry Naoto Haraguchi verfasserin aut Hiroki Oguri verfasserin aut In Tetrahedron Chem Elsevier, 2022 1(2022), Seite 100010- (DE-627)178621475X 2666951X nnns volume:1 year:2022 pages:100010- https://doi.org/10.1016/j.tchem.2022.100010 kostenfrei https://doaj.org/article/e22ed92458ef4d5c93cca856ac4db42a kostenfrei http://www.sciencedirect.com/science/article/pii/S2666951X22000067 kostenfrei https://doaj.org/toc/2666-951X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2022 100010-
language	English
source	In Tetrahedron Chem 1(2022), Seite 100010- volume:1 year:2022 pages:100010-
sourceStr	In Tetrahedron Chem 1(2022), Seite 100010- volume:1 year:2022 pages:100010-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis Organic chemistry
isfreeaccess_bool	true
container_title	Tetrahedron Chem
authorswithroles_txt_mv	Ryo Tanifuji @@aut@@ Naoto Haraguchi @@aut@@ Hiroki Oguri @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	178621475X
id	DOAJ029956773
language_de	englisch
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callnumber-first	Q - Science
author	Ryo Tanifuji
spellingShingle	Ryo Tanifuji misc QD241-441 misc Chemo-enzymatic synthesis misc Tetrahydroisoquinoline alkaloids misc Non-ribosomal peptide synthetase misc Total synthesis misc Organic chemistry Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC
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topic_title	QD241-441 Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis
topic	misc QD241-441 misc Chemo-enzymatic synthesis misc Tetrahydroisoquinoline alkaloids misc Non-ribosomal peptide synthetase misc Total synthesis misc Organic chemistry
topic_unstemmed	misc QD241-441 misc Chemo-enzymatic synthesis misc Tetrahydroisoquinoline alkaloids misc Non-ribosomal peptide synthetase misc Total synthesis misc Organic chemistry
topic_browse	misc QD241-441 misc Chemo-enzymatic synthesis misc Tetrahydroisoquinoline alkaloids misc Non-ribosomal peptide synthetase misc Total synthesis misc Organic chemistry
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title	Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC
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title_full	Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC
author_sort	Ryo Tanifuji
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title_sort	chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of sfmc
callnumber	QD241-441
title_auth	Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC
abstract	Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives.
abstractGer	Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives.
abstract_unstemmed	Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with installation of various amino acids in place of l-Ala were systematically generated, demonstrating the substantially broader substrate scope of SfmC. This chemo-enzymatic hybrid process can considerably minimize the number of steps, labor, and time, and thus offer a rapid and versatile means to generate therapeutically important natural products and their derivatives.
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title_short	Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC
url	https://doi.org/10.1016/j.tchem.2022.100010 https://doaj.org/article/e22ed92458ef4d5c93cca856ac4db42a http://www.sciencedirect.com/science/article/pii/S2666951X22000067 https://doaj.org/toc/2666-951X
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Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC

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