Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were...
Ausführliche Beschreibung
Autor*in: |
Huaqiang Li [verfasserIn] Weiguang Sun [verfasserIn] Mengyi Deng [verfasserIn] Changxing Qi [verfasserIn] Chunmei Chen [verfasserIn] Hucheng Zhu [verfasserIn] Zengwei Luo [verfasserIn] Jianping Wang [verfasserIn] Yongbo Xue [verfasserIn] Yonghui Zhang [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
In: Marine Drugs - MDPI AG, 2005, 16(2018), 6, p 177 |
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Übergeordnetes Werk: |
volume:16 ; year:2018 ; number:6, p 177 |
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DOI / URN: |
10.3390/md16060177 |
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Katalog-ID: |
DOAJ030062594 |
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10.3390/md16060177 doi (DE-627)DOAJ030062594 (DE-599)DOAJb7b2cb708dca4485ad2178c291762905 DE-627 ger DE-627 rakwb eng QH301-705.5 Huaqiang Li verfasserin aut Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. Aspergillus versicolor meroterpenoids asperversins acetylcholinesterase enzyme Biology (General) Weiguang Sun verfasserin aut Mengyi Deng verfasserin aut Changxing Qi verfasserin aut Chunmei Chen verfasserin aut Hucheng Zhu verfasserin aut Zengwei Luo verfasserin aut Jianping Wang verfasserin aut Yongbo Xue verfasserin aut Yonghui Zhang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 6, p 177 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:6, p 177 https://doi.org/10.3390/md16060177 kostenfrei https://doaj.org/article/b7b2cb708dca4485ad2178c291762905 kostenfrei http://www.mdpi.com/1660-3397/16/6/177 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 6, p 177 |
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10.3390/md16060177 doi (DE-627)DOAJ030062594 (DE-599)DOAJb7b2cb708dca4485ad2178c291762905 DE-627 ger DE-627 rakwb eng QH301-705.5 Huaqiang Li verfasserin aut Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. Aspergillus versicolor meroterpenoids asperversins acetylcholinesterase enzyme Biology (General) Weiguang Sun verfasserin aut Mengyi Deng verfasserin aut Changxing Qi verfasserin aut Chunmei Chen verfasserin aut Hucheng Zhu verfasserin aut Zengwei Luo verfasserin aut Jianping Wang verfasserin aut Yongbo Xue verfasserin aut Yonghui Zhang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 6, p 177 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:6, p 177 https://doi.org/10.3390/md16060177 kostenfrei https://doaj.org/article/b7b2cb708dca4485ad2178c291762905 kostenfrei http://www.mdpi.com/1660-3397/16/6/177 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 6, p 177 |
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10.3390/md16060177 doi (DE-627)DOAJ030062594 (DE-599)DOAJb7b2cb708dca4485ad2178c291762905 DE-627 ger DE-627 rakwb eng QH301-705.5 Huaqiang Li verfasserin aut Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. Aspergillus versicolor meroterpenoids asperversins acetylcholinesterase enzyme Biology (General) Weiguang Sun verfasserin aut Mengyi Deng verfasserin aut Changxing Qi verfasserin aut Chunmei Chen verfasserin aut Hucheng Zhu verfasserin aut Zengwei Luo verfasserin aut Jianping Wang verfasserin aut Yongbo Xue verfasserin aut Yonghui Zhang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 6, p 177 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:6, p 177 https://doi.org/10.3390/md16060177 kostenfrei https://doaj.org/article/b7b2cb708dca4485ad2178c291762905 kostenfrei http://www.mdpi.com/1660-3397/16/6/177 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 6, p 177 |
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10.3390/md16060177 doi (DE-627)DOAJ030062594 (DE-599)DOAJb7b2cb708dca4485ad2178c291762905 DE-627 ger DE-627 rakwb eng QH301-705.5 Huaqiang Li verfasserin aut Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. Aspergillus versicolor meroterpenoids asperversins acetylcholinesterase enzyme Biology (General) Weiguang Sun verfasserin aut Mengyi Deng verfasserin aut Changxing Qi verfasserin aut Chunmei Chen verfasserin aut Hucheng Zhu verfasserin aut Zengwei Luo verfasserin aut Jianping Wang verfasserin aut Yongbo Xue verfasserin aut Yonghui Zhang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 6, p 177 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:6, p 177 https://doi.org/10.3390/md16060177 kostenfrei https://doaj.org/article/b7b2cb708dca4485ad2178c291762905 kostenfrei http://www.mdpi.com/1660-3397/16/6/177 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 6, p 177 |
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10.3390/md16060177 doi (DE-627)DOAJ030062594 (DE-599)DOAJb7b2cb708dca4485ad2178c291762905 DE-627 ger DE-627 rakwb eng QH301-705.5 Huaqiang Li verfasserin aut Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. Aspergillus versicolor meroterpenoids asperversins acetylcholinesterase enzyme Biology (General) Weiguang Sun verfasserin aut Mengyi Deng verfasserin aut Changxing Qi verfasserin aut Chunmei Chen verfasserin aut Hucheng Zhu verfasserin aut Zengwei Luo verfasserin aut Jianping Wang verfasserin aut Yongbo Xue verfasserin aut Yonghui Zhang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 6, p 177 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:6, p 177 https://doi.org/10.3390/md16060177 kostenfrei https://doaj.org/article/b7b2cb708dca4485ad2178c291762905 kostenfrei http://www.mdpi.com/1660-3397/16/6/177 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 6, p 177 |
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QH301-705.5 Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor Aspergillus versicolor meroterpenoids asperversins acetylcholinesterase enzyme |
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asperversins a and b, two novel meroterpenoids with an unusual 5/6/6/6 ring from the marine-derived fungus aspergillus versicolor |
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Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor |
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Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. |
abstractGer |
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. |
abstract_unstemmed |
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. |
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Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor |
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