Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?

The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus <i<Burkholderia</i< has recently emerged as a source of n...
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Autor*in:	Sudarshan Singh Thapa [verfasserIn] Anne Grove [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	antibiotics biosynthetic gene clusters gene regulation global transcriptional regulator MftR ScmR secondary metabolites

Übergeordnetes Werk:	In: Antibiotics - MDPI AG, 2013, 8(2019), 4, p 160
Übergeordnetes Werk:	volume:8 ; year:2019 ; number:4, p 160

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antibiotics8040160

Katalog-ID:	DOAJ030137659

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allfields	10.3390/antibiotics8040160 doi (DE-627)DOAJ030137659 (DE-599)DOAJ13a5795e9279454ebd010eff14f25450 DE-627 ger DE-627 rakwb eng RM1-950 Sudarshan Singh Thapa verfasserin aut Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus <i<Burkholderia</i< has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle in identification and isolation of these compounds. Various strategies, such as changes in growth conditions and antibiotic stress, have been applied to elicit the expression of these cryptic gene clusters. Although a number of compounds have been isolated from different <i<Burkholderia</i< species, the mechanisms by which the corresponding gene clusters are regulated remain poorly understood. This review summarizes the activity of well characterized secondary metabolites from <i<Burkholderia</i< species and the role of local regulators in their synthesis, and it highlights recent evidence for the role of global regulators in controlling production of secondary metabolites. We suggest that targeting global regulators holds great promise for the awakening of cryptic gene clusters and for developing better strategies for discovery of novel antibiotics. antibiotics biosynthetic gene clusters <i<Burkholderia</i< gene regulation global transcriptional regulator MftR ScmR secondary metabolites Therapeutics. Pharmacology Anne Grove verfasserin aut In Antibiotics MDPI AG, 2013 8(2019), 4, p 160 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:8 year:2019 number:4, p 160 https://doi.org/10.3390/antibiotics8040160 kostenfrei https://doaj.org/article/13a5795e9279454ebd010eff14f25450 kostenfrei https://www.mdpi.com/2079-6382/8/4/160 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 4, p 160
spelling	10.3390/antibiotics8040160 doi (DE-627)DOAJ030137659 (DE-599)DOAJ13a5795e9279454ebd010eff14f25450 DE-627 ger DE-627 rakwb eng RM1-950 Sudarshan Singh Thapa verfasserin aut Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus <i<Burkholderia</i< has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle in identification and isolation of these compounds. Various strategies, such as changes in growth conditions and antibiotic stress, have been applied to elicit the expression of these cryptic gene clusters. Although a number of compounds have been isolated from different <i<Burkholderia</i< species, the mechanisms by which the corresponding gene clusters are regulated remain poorly understood. This review summarizes the activity of well characterized secondary metabolites from <i<Burkholderia</i< species and the role of local regulators in their synthesis, and it highlights recent evidence for the role of global regulators in controlling production of secondary metabolites. We suggest that targeting global regulators holds great promise for the awakening of cryptic gene clusters and for developing better strategies for discovery of novel antibiotics. antibiotics biosynthetic gene clusters <i<Burkholderia</i< gene regulation global transcriptional regulator MftR ScmR secondary metabolites Therapeutics. Pharmacology Anne Grove verfasserin aut In Antibiotics MDPI AG, 2013 8(2019), 4, p 160 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:8 year:2019 number:4, p 160 https://doi.org/10.3390/antibiotics8040160 kostenfrei https://doaj.org/article/13a5795e9279454ebd010eff14f25450 kostenfrei https://www.mdpi.com/2079-6382/8/4/160 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 4, p 160
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allfieldsSound	10.3390/antibiotics8040160 doi (DE-627)DOAJ030137659 (DE-599)DOAJ13a5795e9279454ebd010eff14f25450 DE-627 ger DE-627 rakwb eng RM1-950 Sudarshan Singh Thapa verfasserin aut Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus <i<Burkholderia</i< has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle in identification and isolation of these compounds. Various strategies, such as changes in growth conditions and antibiotic stress, have been applied to elicit the expression of these cryptic gene clusters. Although a number of compounds have been isolated from different <i<Burkholderia</i< species, the mechanisms by which the corresponding gene clusters are regulated remain poorly understood. This review summarizes the activity of well characterized secondary metabolites from <i<Burkholderia</i< species and the role of local regulators in their synthesis, and it highlights recent evidence for the role of global regulators in controlling production of secondary metabolites. We suggest that targeting global regulators holds great promise for the awakening of cryptic gene clusters and for developing better strategies for discovery of novel antibiotics. antibiotics biosynthetic gene clusters <i<Burkholderia</i< gene regulation global transcriptional regulator MftR ScmR secondary metabolites Therapeutics. Pharmacology Anne Grove verfasserin aut In Antibiotics MDPI AG, 2013 8(2019), 4, p 160 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:8 year:2019 number:4, p 160 https://doi.org/10.3390/antibiotics8040160 kostenfrei https://doaj.org/article/13a5795e9279454ebd010eff14f25450 kostenfrei https://www.mdpi.com/2079-6382/8/4/160 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 4, p 160
language	English
source	In Antibiotics 8(2019), 4, p 160 volume:8 year:2019 number:4, p 160
sourceStr	In Antibiotics 8(2019), 4, p 160 volume:8 year:2019 number:4, p 160
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institution	findex.gbv.de
topic_facet	antibiotics biosynthetic gene clusters <i<Burkholderia</i< gene regulation global transcriptional regulator MftR ScmR secondary metabolites Therapeutics. Pharmacology
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container_title	Antibiotics
authorswithroles_txt_mv	Sudarshan Singh Thapa @@aut@@ Anne Grove @@aut@@
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callnumber-first	R - Medicine
author	Sudarshan Singh Thapa
spellingShingle	Sudarshan Singh Thapa misc RM1-950 misc antibiotics misc biosynthetic gene clusters misc <i<Burkholderia</i< misc gene regulation misc global transcriptional regulator misc MftR misc ScmR misc secondary metabolites misc Therapeutics. Pharmacology Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?
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topic_title	RM1-950 Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites? antibiotics biosynthetic gene clusters <i<Burkholderia</i< gene regulation global transcriptional regulator MftR ScmR secondary metabolites
topic	misc RM1-950 misc antibiotics misc biosynthetic gene clusters misc <i<Burkholderia</i< misc gene regulation misc global transcriptional regulator misc MftR misc ScmR misc secondary metabolites misc Therapeutics. Pharmacology
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title	Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?
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title_full	Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?
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title_sort	do global regulators hold the key to production of bacterial secondary metabolites?
callnumber	RM1-950
title_auth	Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?
abstract	The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus <i<Burkholderia</i< has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle in identification and isolation of these compounds. Various strategies, such as changes in growth conditions and antibiotic stress, have been applied to elicit the expression of these cryptic gene clusters. Although a number of compounds have been isolated from different <i<Burkholderia</i< species, the mechanisms by which the corresponding gene clusters are regulated remain poorly understood. This review summarizes the activity of well characterized secondary metabolites from <i<Burkholderia</i< species and the role of local regulators in their synthesis, and it highlights recent evidence for the role of global regulators in controlling production of secondary metabolites. We suggest that targeting global regulators holds great promise for the awakening of cryptic gene clusters and for developing better strategies for discovery of novel antibiotics.
abstractGer	The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus <i<Burkholderia</i< has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle in identification and isolation of these compounds. Various strategies, such as changes in growth conditions and antibiotic stress, have been applied to elicit the expression of these cryptic gene clusters. Although a number of compounds have been isolated from different <i<Burkholderia</i< species, the mechanisms by which the corresponding gene clusters are regulated remain poorly understood. This review summarizes the activity of well characterized secondary metabolites from <i<Burkholderia</i< species and the role of local regulators in their synthesis, and it highlights recent evidence for the role of global regulators in controlling production of secondary metabolites. We suggest that targeting global regulators holds great promise for the awakening of cryptic gene clusters and for developing better strategies for discovery of novel antibiotics.
abstract_unstemmed	The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus <i<Burkholderia</i< has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle in identification and isolation of these compounds. Various strategies, such as changes in growth conditions and antibiotic stress, have been applied to elicit the expression of these cryptic gene clusters. Although a number of compounds have been isolated from different <i<Burkholderia</i< species, the mechanisms by which the corresponding gene clusters are regulated remain poorly understood. This review summarizes the activity of well characterized secondary metabolites from <i<Burkholderia</i< species and the role of local regulators in their synthesis, and it highlights recent evidence for the role of global regulators in controlling production of secondary metabolites. We suggest that targeting global regulators holds great promise for the awakening of cryptic gene clusters and for developing better strategies for discovery of novel antibiotics.
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title_short	Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?
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