Radiation therapy for melanoma brain metastases: a systematic review

Radiation therapy (RT) for melanoma brain metastases, delivered either as whole brain radiation therapy (WBRT) or as stereotactic radiosurgery (SRS), is an established component of treatment for this condition. However, evidence allowing comparison of the outcomes, advantages and disadvantages of th...
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Autor*in:	Thompson John F. [verfasserIn] Williams Gabrielle J. [verfasserIn] Hong Angela M. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	radiation therapy stereotactic radiosurgery melanoma brain metastases

Übergeordnetes Werk:	In: Radiology and Oncology - Sciendo, 2008, 56(2022), 3, Seite 267-284
Übergeordnetes Werk:	volume:56 ; year:2022 ; number:3 ; pages:267-284

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.2478/raon-2022-0032

Katalog-ID:	DOAJ030331331

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520			\|a Radiation therapy (RT) for melanoma brain metastases, delivered either as whole brain radiation therapy (WBRT) or as stereotactic radiosurgery (SRS), is an established component of treatment for this condition. However, evidence allowing comparison of the outcomes, advantages and disadvantages of the two RT modalities is scant, with very few randomised controlled trials having been conducted. This has led to considerable uncertainty and inconsistent guideline recommendations. The present systematic review identified 112 studies reporting outcomes for patients with melanoma brain metastases treated with RT. Three were randomised controlled trials but only one was of sufficient size to be considered informative. Most of the evidence was from non-randomised studies, either specific treatment series or disease cohorts. Criteria for determining treatment choice were reported in only 32 studies and the quality of these studies was variable. From the time of diagnosis of brain metastasis, the median survival after WBRT alone was 3.5 months (IQR 2.4–4.0 months) and for SRS alone it was 7.5 months (IQR 6.7–9.0 months). Overall patient survival increased over time (pre-1989 to 2015) but this was not apparent within specific treatment groups.
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language	English
source	In Radiology and Oncology 56(2022), 3, Seite 267-284 volume:56 year:2022 number:3 pages:267-284
sourceStr	In Radiology and Oncology 56(2022), 3, Seite 267-284 volume:56 year:2022 number:3 pages:267-284
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	radiation therapy stereotactic radiosurgery melanoma brain metastases Medical physics. Medical radiology. Nuclear medicine
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container_title	Radiology and Oncology
authorswithroles_txt_mv	Thompson John F. @@aut@@ Williams Gabrielle J. @@aut@@ Hong Angela M. @@aut@@
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callnumber-first	R - Medicine
author	Thompson John F.
spellingShingle	Thompson John F. misc R895-920 misc radiation therapy misc stereotactic radiosurgery misc melanoma misc brain metastases misc Medical physics. Medical radiology. Nuclear medicine Radiation therapy for melanoma brain metastases: a systematic review
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topic_title	R895-920 Radiation therapy for melanoma brain metastases: a systematic review radiation therapy stereotactic radiosurgery melanoma brain metastases
topic	misc R895-920 misc radiation therapy misc stereotactic radiosurgery misc melanoma misc brain metastases misc Medical physics. Medical radiology. Nuclear medicine
topic_unstemmed	misc R895-920 misc radiation therapy misc stereotactic radiosurgery misc melanoma misc brain metastases misc Medical physics. Medical radiology. Nuclear medicine
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title	Radiation therapy for melanoma brain metastases: a systematic review
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title_full	Radiation therapy for melanoma brain metastases: a systematic review
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title_sort	radiation therapy for melanoma brain metastases: a systematic review
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title_auth	Radiation therapy for melanoma brain metastases: a systematic review
abstract	Radiation therapy (RT) for melanoma brain metastases, delivered either as whole brain radiation therapy (WBRT) or as stereotactic radiosurgery (SRS), is an established component of treatment for this condition. However, evidence allowing comparison of the outcomes, advantages and disadvantages of the two RT modalities is scant, with very few randomised controlled trials having been conducted. This has led to considerable uncertainty and inconsistent guideline recommendations. The present systematic review identified 112 studies reporting outcomes for patients with melanoma brain metastases treated with RT. Three were randomised controlled trials but only one was of sufficient size to be considered informative. Most of the evidence was from non-randomised studies, either specific treatment series or disease cohorts. Criteria for determining treatment choice were reported in only 32 studies and the quality of these studies was variable. From the time of diagnosis of brain metastasis, the median survival after WBRT alone was 3.5 months (IQR 2.4–4.0 months) and for SRS alone it was 7.5 months (IQR 6.7–9.0 months). Overall patient survival increased over time (pre-1989 to 2015) but this was not apparent within specific treatment groups.
abstractGer	Radiation therapy (RT) for melanoma brain metastases, delivered either as whole brain radiation therapy (WBRT) or as stereotactic radiosurgery (SRS), is an established component of treatment for this condition. However, evidence allowing comparison of the outcomes, advantages and disadvantages of the two RT modalities is scant, with very few randomised controlled trials having been conducted. This has led to considerable uncertainty and inconsistent guideline recommendations. The present systematic review identified 112 studies reporting outcomes for patients with melanoma brain metastases treated with RT. Three were randomised controlled trials but only one was of sufficient size to be considered informative. Most of the evidence was from non-randomised studies, either specific treatment series or disease cohorts. Criteria for determining treatment choice were reported in only 32 studies and the quality of these studies was variable. From the time of diagnosis of brain metastasis, the median survival after WBRT alone was 3.5 months (IQR 2.4–4.0 months) and for SRS alone it was 7.5 months (IQR 6.7–9.0 months). Overall patient survival increased over time (pre-1989 to 2015) but this was not apparent within specific treatment groups.
abstract_unstemmed	Radiation therapy (RT) for melanoma brain metastases, delivered either as whole brain radiation therapy (WBRT) or as stereotactic radiosurgery (SRS), is an established component of treatment for this condition. However, evidence allowing comparison of the outcomes, advantages and disadvantages of the two RT modalities is scant, with very few randomised controlled trials having been conducted. This has led to considerable uncertainty and inconsistent guideline recommendations. The present systematic review identified 112 studies reporting outcomes for patients with melanoma brain metastases treated with RT. Three were randomised controlled trials but only one was of sufficient size to be considered informative. Most of the evidence was from non-randomised studies, either specific treatment series or disease cohorts. Criteria for determining treatment choice were reported in only 32 studies and the quality of these studies was variable. From the time of diagnosis of brain metastasis, the median survival after WBRT alone was 3.5 months (IQR 2.4–4.0 months) and for SRS alone it was 7.5 months (IQR 6.7–9.0 months). Overall patient survival increased over time (pre-1989 to 2015) but this was not apparent within specific treatment groups.
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title_short	Radiation therapy for melanoma brain metastases: a systematic review
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