New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique

Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition...
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Autor*in:	Aleksandra A. Ageeva [verfasserIn] Alexander I. Kruppa [verfasserIn] Ilya M. Magin [verfasserIn] Simon V. Babenko [verfasserIn] Tatyana V. Leshina [verfasserIn] Nikolay E. Polyakov [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	glycyrrhizin antioxidant activity free radicals solvated electron photo-CIDNP naproxen

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 11(2022), 8, p 1591
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:8, p 1591

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox11081591

Katalog-ID:	DOAJ03040701X

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language	English
source	In Antioxidants 11(2022), 8, p 1591 volume:11 year:2022 number:8, p 1591
sourceStr	In Antioxidants 11(2022), 8, p 1591 volume:11 year:2022 number:8, p 1591
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	glycyrrhizin antioxidant activity free radicals solvated electron photo-CIDNP naproxen Therapeutics. Pharmacology
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container_title	Antioxidants
authorswithroles_txt_mv	Aleksandra A. Ageeva @@aut@@ Alexander I. Kruppa @@aut@@ Ilya M. Magin @@aut@@ Simon V. Babenko @@aut@@ Tatyana V. Leshina @@aut@@ Nikolay E. Polyakov @@aut@@
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callnumber-first	R - Medicine
author	Aleksandra A. Ageeva
spellingShingle	Aleksandra A. Ageeva misc RM1-950 misc glycyrrhizin misc antioxidant activity misc free radicals misc solvated electron misc photo-CIDNP misc naproxen misc Therapeutics. Pharmacology New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique
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topic_title	RM1-950 New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique glycyrrhizin antioxidant activity free radicals solvated electron photo-CIDNP naproxen
topic	misc RM1-950 misc glycyrrhizin misc antioxidant activity misc free radicals misc solvated electron misc photo-CIDNP misc naproxen misc Therapeutics. Pharmacology
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title	New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique
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title_sort	new aspects of the antioxidant activity of glycyrrhizin revealed by the cidnp technique
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title_auth	New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique
abstract	Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition of ROS generation, and the second is the trapping of free radicals. In the present study, we have elucidated both these mechanisms of antioxidant activity of glycyrrhizin (GL), the main active component of licorice root, using the chemically induced dynamic nuclear polarization (CIDNP) technique. First, it was shown that GL is capable of capturing a solvated electron, thereby preventing its capture by molecular oxygen. Second, we studied the effect of glycyrrhizin on the behavior of free radicals generated by UV irradiation of xenobiotic, NSAID—naproxen in solution. The structure of the glycyrrhizin paramagnetic intermediates formed after the capture of a solvated electron was established from a photo-CIDNP study of the model system—the dianion of 5-sulfosalicylic acid and DFT calculations.
abstractGer	Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition of ROS generation, and the second is the trapping of free radicals. In the present study, we have elucidated both these mechanisms of antioxidant activity of glycyrrhizin (GL), the main active component of licorice root, using the chemically induced dynamic nuclear polarization (CIDNP) technique. First, it was shown that GL is capable of capturing a solvated electron, thereby preventing its capture by molecular oxygen. Second, we studied the effect of glycyrrhizin on the behavior of free radicals generated by UV irradiation of xenobiotic, NSAID—naproxen in solution. The structure of the glycyrrhizin paramagnetic intermediates formed after the capture of a solvated electron was established from a photo-CIDNP study of the model system—the dianion of 5-sulfosalicylic acid and DFT calculations.
abstract_unstemmed	Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition of ROS generation, and the second is the trapping of free radicals. In the present study, we have elucidated both these mechanisms of antioxidant activity of glycyrrhizin (GL), the main active component of licorice root, using the chemically induced dynamic nuclear polarization (CIDNP) technique. First, it was shown that GL is capable of capturing a solvated electron, thereby preventing its capture by molecular oxygen. Second, we studied the effect of glycyrrhizin on the behavior of free radicals generated by UV irradiation of xenobiotic, NSAID—naproxen in solution. The structure of the glycyrrhizin paramagnetic intermediates formed after the capture of a solvated electron was established from a photo-CIDNP study of the model system—the dianion of 5-sulfosalicylic acid and DFT calculations.
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title_short	New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique
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