Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

Skeletal muscle-derived PW1pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber...
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Autor*in:	Fiona C. Lewis, BSc, PhD [verfasserIn] Beverley J. Cottle, BSc, PhD [verfasserIn] Victoria Shone, BSc, MSc, PhD [verfasserIn] Giovanna Marazzi, MD [verfasserIn] David Sassoon, PhD [verfasserIn] Cheyenne C.S. Tseng, MD [verfasserIn] Patricia Y.W. Dankers, PhD [verfasserIn] Steven A.J. Chamuleau, MD, PhD [verfasserIn] Bernardo Nadal-Ginard, MD, PhD [verfasserIn] Georgina M. Ellison-Hughes, BSc, PhD [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	allogeneic progenitor cells growth factors PICs porcine preclinical model regeneration skeletal muscle

Übergeordnetes Werk:	In: JACC: Basic to Translational Science - Elsevier, 2017, 2(2017), 6, Seite 717-736
Übergeordnetes Werk:	volume:2 ; year:2017 ; number:6 ; pages:717-736

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jacbts.2017.08.002

Katalog-ID:	DOAJ030560608

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allfieldsSound	10.1016/j.jacbts.2017.08.002 doi (DE-627)DOAJ030560608 (DE-599)DOAJ263f81d3ce8e4043b6a52ae6dc467ffe DE-627 ger DE-627 rakwb eng RC666-701 Fiona C. Lewis, BSc, PhD verfasserin aut Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle-derived PW1pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy. allogeneic progenitor cells growth factors PICs porcine preclinical model regeneration skeletal muscle Diseases of the circulatory (Cardiovascular) system Beverley J. Cottle, BSc, PhD verfasserin aut Victoria Shone, BSc, MSc, PhD verfasserin aut Giovanna Marazzi, MD verfasserin aut David Sassoon, PhD verfasserin aut Cheyenne C.S. Tseng, MD verfasserin aut Patricia Y.W. Dankers, PhD verfasserin aut Steven A.J. Chamuleau, MD, PhD verfasserin aut Bernardo Nadal-Ginard, MD, PhD verfasserin aut Georgina M. Ellison-Hughes, BSc, PhD verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 2(2017), 6, Seite 717-736 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:2 year:2017 number:6 pages:717-736 https://doi.org/10.1016/j.jacbts.2017.08.002 kostenfrei https://doaj.org/article/263f81d3ce8e4043b6a52ae6dc467ffe kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302255 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2017 6 717-736
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source	In JACC: Basic to Translational Science 2(2017), 6, Seite 717-736 volume:2 year:2017 number:6 pages:717-736
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topic_facet	allogeneic progenitor cells growth factors PICs porcine preclinical model regeneration skeletal muscle Diseases of the circulatory (Cardiovascular) system
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container_title	JACC: Basic to Translational Science
authorswithroles_txt_mv	Fiona C. Lewis, BSc, PhD @@aut@@ Beverley J. Cottle, BSc, PhD @@aut@@ Victoria Shone, BSc, MSc, PhD @@aut@@ Giovanna Marazzi, MD @@aut@@ David Sassoon, PhD @@aut@@ Cheyenne C.S. Tseng, MD @@aut@@ Patricia Y.W. Dankers, PhD @@aut@@ Steven A.J. Chamuleau, MD, PhD @@aut@@ Bernardo Nadal-Ginard, MD, PhD @@aut@@ Georgina M. Ellison-Hughes, BSc, PhD @@aut@@
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callnumber-first	R - Medicine
author	Fiona C. Lewis, BSc, PhD
spellingShingle	Fiona C. Lewis, BSc, PhD misc RC666-701 misc allogeneic progenitor cells misc growth factors misc PICs misc porcine preclinical model misc regeneration misc skeletal muscle misc Diseases of the circulatory (Cardiovascular) system Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
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topic_title	RC666-701 Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle allogeneic progenitor cells growth factors PICs porcine preclinical model regeneration skeletal muscle
topic	misc RC666-701 misc allogeneic progenitor cells misc growth factors misc PICs misc porcine preclinical model misc regeneration misc skeletal muscle misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc allogeneic progenitor cells misc growth factors misc PICs misc porcine preclinical model misc regeneration misc skeletal muscle misc Diseases of the circulatory (Cardiovascular) system
topic_browse	misc RC666-701 misc allogeneic progenitor cells misc growth factors misc PICs misc porcine preclinical model misc regeneration misc skeletal muscle misc Diseases of the circulatory (Cardiovascular) system
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title	Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
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title_full	Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
author_sort	Fiona C. Lewis, BSc, PhD
journal	JACC: Basic to Translational Science
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author_browse	Fiona C. Lewis, BSc, PhD Beverley J. Cottle, BSc, PhD Victoria Shone, BSc, MSc, PhD Giovanna Marazzi, MD David Sassoon, PhD Cheyenne C.S. Tseng, MD Patricia Y.W. Dankers, PhD Steven A.J. Chamuleau, MD, PhD Bernardo Nadal-Ginard, MD, PhD Georgina M. Ellison-Hughes, BSc, PhD
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author-letter	Fiona C. Lewis, BSc, PhD
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title_sort	transplantation of allogeneic pw1pos/pax7neg interstitial cells enhance endogenous repair of injured porcine skeletal muscle
callnumber	RC666-701
title_auth	Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
abstract	Skeletal muscle-derived PW1pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy.
abstractGer	Skeletal muscle-derived PW1pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy.
abstract_unstemmed	Skeletal muscle-derived PW1pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy.
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title_short	Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
url	https://doi.org/10.1016/j.jacbts.2017.08.002 https://doaj.org/article/263f81d3ce8e4043b6a52ae6dc467ffe http://www.sciencedirect.com/science/article/pii/S2452302X17302255 https://doaj.org/toc/2452-302X
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author2	Beverley J. Cottle, BSc, PhD Victoria Shone, BSc, MSc, PhD Giovanna Marazzi, MD David Sassoon, PhD Cheyenne C.S. Tseng, MD Patricia Y.W. Dankers, PhD Steven A.J. Chamuleau, MD, PhD Bernardo Nadal-Ginard, MD, PhD Georgina M. Ellison-Hughes, BSc, PhD
author2Str	Beverley J. Cottle, BSc, PhD Victoria Shone, BSc, MSc, PhD Giovanna Marazzi, MD David Sassoon, PhD Cheyenne C.S. Tseng, MD Patricia Y.W. Dankers, PhD Steven A.J. Chamuleau, MD, PhD Bernardo Nadal-Ginard, MD, PhD Georgina M. Ellison-Hughes, BSc, PhD
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doi_str	10.1016/j.jacbts.2017.08.002
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up_date	2024-07-03T15:43:20.771Z
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Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

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