What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy
Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic l...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Andrea Palicelli [verfasserIn] Martina Bonacini [verfasserIn] Stefania Croci [verfasserIn] Alessandra Bisagni [verfasserIn] Eleonora Zanetti [verfasserIn] Dario De Biase [verfasserIn] Francesca Sanguedolce [verfasserIn] Moira Ragazzi [verfasserIn] Magda Zanelli [verfasserIn] Alcides Chaux [verfasserIn] Sofia Cañete-Portillo [verfasserIn] Maria Paola Bonasoni [verfasserIn] Stefano Ascani [verfasserIn] Antonio De Leo [verfasserIn] Jatin Gandhi [verfasserIn] Alessandro Tafuni [verfasserIn] Beatrice Melli [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Personalized Medicine - MDPI AG, 2012, 11(2021), 12, p 1312 |
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| Übergeordnetes Werk: |
volume:11 ; year:2021 ; number:12, p 1312 |
| Links: |
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| DOI / URN: |
10.3390/jpm11121312 |
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| Katalog-ID: |
DOAJ030561507 |
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| 520 | |a Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. | ||
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10.3390/jpm11121312 doi (DE-627)DOAJ030561507 (DE-599)DOAJc3b5522dddf54524b6ecac7b86b70162 DE-627 ger DE-627 rakwb eng Andrea Palicelli verfasserin aut What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. PD-L1 prostate cancer liquid biopsy circulating tumor cells exosomes Medicine R Martina Bonacini verfasserin aut Stefania Croci verfasserin aut Alessandra Bisagni verfasserin aut Eleonora Zanetti verfasserin aut Dario De Biase verfasserin aut Francesca Sanguedolce verfasserin aut Moira Ragazzi verfasserin aut Magda Zanelli verfasserin aut Alcides Chaux verfasserin aut Sofia Cañete-Portillo verfasserin aut Maria Paola Bonasoni verfasserin aut Stefano Ascani verfasserin aut Antonio De Leo verfasserin aut Jatin Gandhi verfasserin aut Alessandro Tafuni verfasserin aut Beatrice Melli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 12, p 1312 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:12, p 1312 https://doi.org/10.3390/jpm11121312 kostenfrei https://doaj.org/article/c3b5522dddf54524b6ecac7b86b70162 kostenfrei https://www.mdpi.com/2075-4426/11/12/1312 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1312 |
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10.3390/jpm11121312 doi (DE-627)DOAJ030561507 (DE-599)DOAJc3b5522dddf54524b6ecac7b86b70162 DE-627 ger DE-627 rakwb eng Andrea Palicelli verfasserin aut What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. PD-L1 prostate cancer liquid biopsy circulating tumor cells exosomes Medicine R Martina Bonacini verfasserin aut Stefania Croci verfasserin aut Alessandra Bisagni verfasserin aut Eleonora Zanetti verfasserin aut Dario De Biase verfasserin aut Francesca Sanguedolce verfasserin aut Moira Ragazzi verfasserin aut Magda Zanelli verfasserin aut Alcides Chaux verfasserin aut Sofia Cañete-Portillo verfasserin aut Maria Paola Bonasoni verfasserin aut Stefano Ascani verfasserin aut Antonio De Leo verfasserin aut Jatin Gandhi verfasserin aut Alessandro Tafuni verfasserin aut Beatrice Melli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 12, p 1312 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:12, p 1312 https://doi.org/10.3390/jpm11121312 kostenfrei https://doaj.org/article/c3b5522dddf54524b6ecac7b86b70162 kostenfrei https://www.mdpi.com/2075-4426/11/12/1312 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1312 |
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10.3390/jpm11121312 doi (DE-627)DOAJ030561507 (DE-599)DOAJc3b5522dddf54524b6ecac7b86b70162 DE-627 ger DE-627 rakwb eng Andrea Palicelli verfasserin aut What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. PD-L1 prostate cancer liquid biopsy circulating tumor cells exosomes Medicine R Martina Bonacini verfasserin aut Stefania Croci verfasserin aut Alessandra Bisagni verfasserin aut Eleonora Zanetti verfasserin aut Dario De Biase verfasserin aut Francesca Sanguedolce verfasserin aut Moira Ragazzi verfasserin aut Magda Zanelli verfasserin aut Alcides Chaux verfasserin aut Sofia Cañete-Portillo verfasserin aut Maria Paola Bonasoni verfasserin aut Stefano Ascani verfasserin aut Antonio De Leo verfasserin aut Jatin Gandhi verfasserin aut Alessandro Tafuni verfasserin aut Beatrice Melli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 12, p 1312 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:12, p 1312 https://doi.org/10.3390/jpm11121312 kostenfrei https://doaj.org/article/c3b5522dddf54524b6ecac7b86b70162 kostenfrei https://www.mdpi.com/2075-4426/11/12/1312 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1312 |
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10.3390/jpm11121312 doi (DE-627)DOAJ030561507 (DE-599)DOAJc3b5522dddf54524b6ecac7b86b70162 DE-627 ger DE-627 rakwb eng Andrea Palicelli verfasserin aut What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. PD-L1 prostate cancer liquid biopsy circulating tumor cells exosomes Medicine R Martina Bonacini verfasserin aut Stefania Croci verfasserin aut Alessandra Bisagni verfasserin aut Eleonora Zanetti verfasserin aut Dario De Biase verfasserin aut Francesca Sanguedolce verfasserin aut Moira Ragazzi verfasserin aut Magda Zanelli verfasserin aut Alcides Chaux verfasserin aut Sofia Cañete-Portillo verfasserin aut Maria Paola Bonasoni verfasserin aut Stefano Ascani verfasserin aut Antonio De Leo verfasserin aut Jatin Gandhi verfasserin aut Alessandro Tafuni verfasserin aut Beatrice Melli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 12, p 1312 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:12, p 1312 https://doi.org/10.3390/jpm11121312 kostenfrei https://doaj.org/article/c3b5522dddf54524b6ecac7b86b70162 kostenfrei https://www.mdpi.com/2075-4426/11/12/1312 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1312 |
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what do we have to know about pd-l1 expression in prostate cancer? a systematic literature review. part 7: pd-l1 expression in liquid biopsy |
| title_auth |
What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy |
| abstract |
Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. |
| abstractGer |
Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. |
| abstract_unstemmed |
Liquid biopsy is an accessible, non-invasive diagnostic tool for advanced prostate cancer (PC) patients, potentially representing a real-time monitoring test for tumor evolution and response to treatment through the analysis of circulating tumor cells (CTCs) and exosomes. We performed a systematic literature review (PRISMA guidelines) to describe the current knowledge about PD-L1 expression in liquid biopsies of PC patients: 101/159 (64%) cases revealed a variable number of PD-L1+ CTCs. Outcome correlations should be investigated in larger series. Nuclear PD-L1 expression by CTCs was occasionally associated with worse prognosis. Treatment (abiraterone, enzalutamide, radiotherapy, checkpoint-inhibitors) influenced PD-L1+ CTC levels. Discordance in PD-L1 status was detected between primary vs. metastatic PC tissue biopsies and CTCs vs. corresponding tumor tissues. PD-L1 is also released by PC cells through soluble exosomes, which could inhibit the T cell function, causing immune evasion. PD-L1+ PC-CTC monitoring and genomic profiling may better characterize the ongoing aggressive PC forms compared to PD-L1 evaluation on primary tumor biopsies/prostatectomy specimens (sometimes sampled a long time before recurrence/progression). Myeloid-derived suppressor cells and dendritic cells (DCs), which may have immune-suppressive effects in tumor microenvironment, have been found in PC patients circulation, sometimes expressing PD-L1. Occasionally, their levels correlated to clinical outcome. Enzalutamide-progressing castration-resistant PC patients revealed increased PD-1+ T cells and circulating PD-L1/2+ DCs. |
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What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy |
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https://doi.org/10.3390/jpm11121312 https://doaj.org/article/c3b5522dddf54524b6ecac7b86b70162 https://www.mdpi.com/2075-4426/11/12/1312 https://doaj.org/toc/2075-4426 |
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Martina Bonacini Stefania Croci Alessandra Bisagni Eleonora Zanetti Dario De Biase Francesca Sanguedolce Moira Ragazzi Magda Zanelli Alcides Chaux Sofia Cañete-Portillo Maria Paola Bonasoni Stefano Ascani Antonio De Leo Jatin Gandhi Alessandro Tafuni Beatrice Melli |
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Martina Bonacini Stefania Croci Alessandra Bisagni Eleonora Zanetti Dario De Biase Francesca Sanguedolce Moira Ragazzi Magda Zanelli Alcides Chaux Sofia Cañete-Portillo Maria Paola Bonasoni Stefano Ascani Antonio De Leo Jatin Gandhi Alessandro Tafuni Beatrice Melli |
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