Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties

The creation of artificial biocomposites consisting of biocompatible materials in combination with bioactive molecules is one of the main tasks of tissue engineering. The development of new materials, which are biocompatible, functional, and also biodegradable in vivo, is a specific problem. Two typ...
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Autor*in:	Mariia Gordienko [verfasserIn] Elena Karakatenko [verfasserIn] Natalia Menshutina [verfasserIn] Marina Koroleva [verfasserIn] Ilmira Gilmutdinova [verfasserIn] Petr Eremin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	hydrophilic and hydrophobic polymers composites hydroxyapatite nanoparticles cell adhesion cytotoxicity acute toxicity

Übergeordnetes Werk:	In: Journal of Functional Biomaterials - MDPI AG, 2011, 12(2021), 4, p 55
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:4, p 55

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jfb12040055

Katalog-ID:	DOAJ030646235

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language	English
source	In Journal of Functional Biomaterials 12(2021), 4, p 55 volume:12 year:2021 number:4, p 55
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authorswithroles_txt_mv	Mariia Gordienko @@aut@@ Elena Karakatenko @@aut@@ Natalia Menshutina @@aut@@ Marina Koroleva @@aut@@ Ilmira Gilmutdinova @@aut@@ Petr Eremin @@aut@@
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callnumber-first	T - Technology
author	Mariia Gordienko
spellingShingle	Mariia Gordienko misc TP248.13-248.65 misc R5-920 misc hydrophilic and hydrophobic polymers composites misc hydroxyapatite nanoparticles misc cell adhesion misc cytotoxicity misc acute toxicity misc Biotechnology misc Medicine (General) Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties
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topic_title	TP248.13-248.65 R5-920 Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties hydrophilic and hydrophobic polymers composites hydroxyapatite nanoparticles cell adhesion cytotoxicity acute toxicity
topic	misc TP248.13-248.65 misc R5-920 misc hydrophilic and hydrophobic polymers composites misc hydroxyapatite nanoparticles misc cell adhesion misc cytotoxicity misc acute toxicity misc Biotechnology misc Medicine (General)
topic_unstemmed	misc TP248.13-248.65 misc R5-920 misc hydrophilic and hydrophobic polymers composites misc hydroxyapatite nanoparticles misc cell adhesion misc cytotoxicity misc acute toxicity misc Biotechnology misc Medicine (General)
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title	Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties
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title_full	Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties
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author_browse	Mariia Gordienko Elena Karakatenko Natalia Menshutina Marina Koroleva Ilmira Gilmutdinova Petr Eremin
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title_sort	composites composed of hydrophilic and hydrophobic polymers, and hydroxyapatite nanoparticles: synthesis, characterization, and study of their biocompatible properties
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title_auth	Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties
abstract	The creation of artificial biocomposites consisting of biocompatible materials in combination with bioactive molecules is one of the main tasks of tissue engineering. The development of new materials, which are biocompatible, functional, and also biodegradable in vivo, is a specific problem. Two types of products can be formed from these materials in the processes of biodegradation. The first types of substances are natural for a living organism and are included in the metabolism of cells, for example, sugars, lactic, glycolic, and β-hydroxybutyric acids. Substances that are not metabolized by cells represent the other type. In the latter case, such products should not be toxic, and their concentration when entering the bloodstream should not exceed the established maximum permissible level. The composite materials based on a mixture of biodegradable synthetic and natural polymers with the addition of hydroxyapatite nanoparticles, which acts as a stabilizer of the dispersed system during production of the composite, and which is a biologically active component of the resulting matrix, were obtained and studied. The indirect effect of the shape, size, and surface charge of hydroxyapatite nanoparticles on the structure and porosity of the formed matrix was shown. An in vivo study showed the absence of acute toxicity of the developed composites.
abstractGer	The creation of artificial biocomposites consisting of biocompatible materials in combination with bioactive molecules is one of the main tasks of tissue engineering. The development of new materials, which are biocompatible, functional, and also biodegradable in vivo, is a specific problem. Two types of products can be formed from these materials in the processes of biodegradation. The first types of substances are natural for a living organism and are included in the metabolism of cells, for example, sugars, lactic, glycolic, and β-hydroxybutyric acids. Substances that are not metabolized by cells represent the other type. In the latter case, such products should not be toxic, and their concentration when entering the bloodstream should not exceed the established maximum permissible level. The composite materials based on a mixture of biodegradable synthetic and natural polymers with the addition of hydroxyapatite nanoparticles, which acts as a stabilizer of the dispersed system during production of the composite, and which is a biologically active component of the resulting matrix, were obtained and studied. The indirect effect of the shape, size, and surface charge of hydroxyapatite nanoparticles on the structure and porosity of the formed matrix was shown. An in vivo study showed the absence of acute toxicity of the developed composites.
abstract_unstemmed	The creation of artificial biocomposites consisting of biocompatible materials in combination with bioactive molecules is one of the main tasks of tissue engineering. The development of new materials, which are biocompatible, functional, and also biodegradable in vivo, is a specific problem. Two types of products can be formed from these materials in the processes of biodegradation. The first types of substances are natural for a living organism and are included in the metabolism of cells, for example, sugars, lactic, glycolic, and β-hydroxybutyric acids. Substances that are not metabolized by cells represent the other type. In the latter case, such products should not be toxic, and their concentration when entering the bloodstream should not exceed the established maximum permissible level. The composite materials based on a mixture of biodegradable synthetic and natural polymers with the addition of hydroxyapatite nanoparticles, which acts as a stabilizer of the dispersed system during production of the composite, and which is a biologically active component of the resulting matrix, were obtained and studied. The indirect effect of the shape, size, and surface charge of hydroxyapatite nanoparticles on the structure and porosity of the formed matrix was shown. An in vivo study showed the absence of acute toxicity of the developed composites.
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title_short	Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties
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Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties

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