Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression

Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used alo...
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Autor*in:	Jinzhen Li [verfasserIn] Li Yang [verfasserIn] Guiyan Li [verfasserIn] Shiying Liu [verfasserIn] Wenhong Cao [verfasserIn] Haisheng Lin [verfasserIn] Zhongqin Chen [verfasserIn] Xiaoming Qin [verfasserIn] Jinzhi Huang [verfasserIn] Huina Zheng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 95(2022), Seite 105196-
Übergeordnetes Werk:	volume:95 ; year:2022 ; pages:105196-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2022.105196

Katalog-ID:	DOAJ030782341

Internformat


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allfields	10.1016/j.jff.2022.105196 doi (DE-627)DOAJ030782341 (DE-599)DOAJe7cc6dd05363417ba42db8cd60bda432 DE-627 ger DE-627 rakwb eng TX341-641 Jinzhen Li verfasserin aut Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy. Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota Nutrition. Foods and food supply Li Yang verfasserin aut Guiyan Li verfasserin aut Shiying Liu verfasserin aut Wenhong Cao verfasserin aut Haisheng Lin verfasserin aut Zhongqin Chen verfasserin aut Xiaoming Qin verfasserin aut Jinzhi Huang verfasserin aut Huina Zheng verfasserin aut In Journal of Functional Foods Elsevier, 2021 95(2022), Seite 105196- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:95 year:2022 pages:105196- https://doi.org/10.1016/j.jff.2022.105196 kostenfrei https://doaj.org/article/e7cc6dd05363417ba42db8cd60bda432 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622002663 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 95 2022 105196-
spelling	10.1016/j.jff.2022.105196 doi (DE-627)DOAJ030782341 (DE-599)DOAJe7cc6dd05363417ba42db8cd60bda432 DE-627 ger DE-627 rakwb eng TX341-641 Jinzhen Li verfasserin aut Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy. Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota Nutrition. Foods and food supply Li Yang verfasserin aut Guiyan Li verfasserin aut Shiying Liu verfasserin aut Wenhong Cao verfasserin aut Haisheng Lin verfasserin aut Zhongqin Chen verfasserin aut Xiaoming Qin verfasserin aut Jinzhi Huang verfasserin aut Huina Zheng verfasserin aut In Journal of Functional Foods Elsevier, 2021 95(2022), Seite 105196- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:95 year:2022 pages:105196- https://doi.org/10.1016/j.jff.2022.105196 kostenfrei https://doaj.org/article/e7cc6dd05363417ba42db8cd60bda432 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622002663 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 95 2022 105196-
allfields_unstemmed	10.1016/j.jff.2022.105196 doi (DE-627)DOAJ030782341 (DE-599)DOAJe7cc6dd05363417ba42db8cd60bda432 DE-627 ger DE-627 rakwb eng TX341-641 Jinzhen Li verfasserin aut Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy. Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota Nutrition. Foods and food supply Li Yang verfasserin aut Guiyan Li verfasserin aut Shiying Liu verfasserin aut Wenhong Cao verfasserin aut Haisheng Lin verfasserin aut Zhongqin Chen verfasserin aut Xiaoming Qin verfasserin aut Jinzhi Huang verfasserin aut Huina Zheng verfasserin aut In Journal of Functional Foods Elsevier, 2021 95(2022), Seite 105196- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:95 year:2022 pages:105196- https://doi.org/10.1016/j.jff.2022.105196 kostenfrei https://doaj.org/article/e7cc6dd05363417ba42db8cd60bda432 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622002663 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 95 2022 105196-
allfieldsGer	10.1016/j.jff.2022.105196 doi (DE-627)DOAJ030782341 (DE-599)DOAJe7cc6dd05363417ba42db8cd60bda432 DE-627 ger DE-627 rakwb eng TX341-641 Jinzhen Li verfasserin aut Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy. Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota Nutrition. Foods and food supply Li Yang verfasserin aut Guiyan Li verfasserin aut Shiying Liu verfasserin aut Wenhong Cao verfasserin aut Haisheng Lin verfasserin aut Zhongqin Chen verfasserin aut Xiaoming Qin verfasserin aut Jinzhi Huang verfasserin aut Huina Zheng verfasserin aut In Journal of Functional Foods Elsevier, 2021 95(2022), Seite 105196- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:95 year:2022 pages:105196- https://doi.org/10.1016/j.jff.2022.105196 kostenfrei https://doaj.org/article/e7cc6dd05363417ba42db8cd60bda432 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622002663 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 95 2022 105196-
allfieldsSound	10.1016/j.jff.2022.105196 doi (DE-627)DOAJ030782341 (DE-599)DOAJe7cc6dd05363417ba42db8cd60bda432 DE-627 ger DE-627 rakwb eng TX341-641 Jinzhen Li verfasserin aut Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy. Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota Nutrition. Foods and food supply Li Yang verfasserin aut Guiyan Li verfasserin aut Shiying Liu verfasserin aut Wenhong Cao verfasserin aut Haisheng Lin verfasserin aut Zhongqin Chen verfasserin aut Xiaoming Qin verfasserin aut Jinzhi Huang verfasserin aut Huina Zheng verfasserin aut In Journal of Functional Foods Elsevier, 2021 95(2022), Seite 105196- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:95 year:2022 pages:105196- https://doi.org/10.1016/j.jff.2022.105196 kostenfrei https://doaj.org/article/e7cc6dd05363417ba42db8cd60bda432 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464622002663 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 95 2022 105196-
language	English
source	In Journal of Functional Foods 95(2022), Seite 105196- volume:95 year:2022 pages:105196-
sourceStr	In Journal of Functional Foods 95(2022), Seite 105196- volume:95 year:2022 pages:105196-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Journal of Functional Foods
authorswithroles_txt_mv	Jinzhen Li @@aut@@ Li Yang @@aut@@ Guiyan Li @@aut@@ Shiying Liu @@aut@@ Wenhong Cao @@aut@@ Haisheng Lin @@aut@@ Zhongqin Chen @@aut@@ Xiaoming Qin @@aut@@ Jinzhi Huang @@aut@@ Huina Zheng @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	587138432
id	DOAJ030782341
language_de	englisch
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callnumber-first	T - Technology
author	Jinzhen Li
spellingShingle	Jinzhen Li misc TX341-641 misc Low-molecular-weight oyster peptides misc Lewis lung cancer misc Cyclophosphamide misc Immune regulation misc Gut microbiota misc Nutrition. Foods and food supply Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression
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topic_title	TX341-641 Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression Low-molecular-weight oyster peptides Lewis lung cancer Cyclophosphamide Immune regulation Gut microbiota
topic	misc TX341-641 misc Low-molecular-weight oyster peptides misc Lewis lung cancer misc Cyclophosphamide misc Immune regulation misc Gut microbiota misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Low-molecular-weight oyster peptides misc Lewis lung cancer misc Cyclophosphamide misc Immune regulation misc Gut microbiota misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc Low-molecular-weight oyster peptides misc Lewis lung cancer misc Cyclophosphamide misc Immune regulation misc Gut microbiota misc Nutrition. Foods and food supply
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title	Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression
ctrlnum	(DE-627)DOAJ030782341 (DE-599)DOAJe7cc6dd05363417ba42db8cd60bda432
title_full	Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression
author_sort	Jinzhen Li
journal	Journal of Functional Foods
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author_browse	Jinzhen Li Li Yang Guiyan Li Shiying Liu Wenhong Cao Haisheng Lin Zhongqin Chen Xiaoming Qin Jinzhi Huang Huina Zheng
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title_sort	low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression
callnumber	TX341-641
title_auth	Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression
abstract	Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy.
abstractGer	Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy.
abstract_unstemmed	Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immunoglobulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy.
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title_short	Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression
url	https://doi.org/10.1016/j.jff.2022.105196 https://doaj.org/article/e7cc6dd05363417ba42db8cd60bda432 http://www.sciencedirect.com/science/article/pii/S1756464622002663 https://doaj.org/toc/1756-4646
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up_date	2024-07-03T16:56:56.235Z
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Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression

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