Further Insights on RNA Expression and Sperm Motility
Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of s...
Ausführliche Beschreibung
Autor*in: |
Carolina Silva [verfasserIn] Paulo Viana [verfasserIn] Alberto Barros [verfasserIn] Rosália Sá [verfasserIn] Mário Sousa [verfasserIn] Rute Pereira [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Genes - MDPI AG, 2010, 13(2022), 7, p 1291 |
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Übergeordnetes Werk: |
volume:13 ; year:2022 ; number:7, p 1291 |
Links: |
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DOI / URN: |
10.3390/genes13071291 |
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Katalog-ID: |
DOAJ030893909 |
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520 | |a Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. | ||
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10.3390/genes13071291 doi (DE-627)DOAJ030893909 (DE-599)DOAJ6c41d9ba4f7b4fe39434e37147e0dbe1 DE-627 ger DE-627 rakwb eng QH426-470 Carolina Silva verfasserin aut Further Insights on RNA Expression and Sperm Motility 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. gene expression male reproduction quantitative PCR RNA sperm motility Genetics Paulo Viana verfasserin aut Alberto Barros verfasserin aut Rosália Sá verfasserin aut Mário Sousa verfasserin aut Rute Pereira verfasserin aut In Genes MDPI AG, 2010 13(2022), 7, p 1291 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:13 year:2022 number:7, p 1291 https://doi.org/10.3390/genes13071291 kostenfrei https://doaj.org/article/6c41d9ba4f7b4fe39434e37147e0dbe1 kostenfrei https://www.mdpi.com/2073-4425/13/7/1291 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 7, p 1291 |
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10.3390/genes13071291 doi (DE-627)DOAJ030893909 (DE-599)DOAJ6c41d9ba4f7b4fe39434e37147e0dbe1 DE-627 ger DE-627 rakwb eng QH426-470 Carolina Silva verfasserin aut Further Insights on RNA Expression and Sperm Motility 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. gene expression male reproduction quantitative PCR RNA sperm motility Genetics Paulo Viana verfasserin aut Alberto Barros verfasserin aut Rosália Sá verfasserin aut Mário Sousa verfasserin aut Rute Pereira verfasserin aut In Genes MDPI AG, 2010 13(2022), 7, p 1291 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:13 year:2022 number:7, p 1291 https://doi.org/10.3390/genes13071291 kostenfrei https://doaj.org/article/6c41d9ba4f7b4fe39434e37147e0dbe1 kostenfrei https://www.mdpi.com/2073-4425/13/7/1291 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 7, p 1291 |
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10.3390/genes13071291 doi (DE-627)DOAJ030893909 (DE-599)DOAJ6c41d9ba4f7b4fe39434e37147e0dbe1 DE-627 ger DE-627 rakwb eng QH426-470 Carolina Silva verfasserin aut Further Insights on RNA Expression and Sperm Motility 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. gene expression male reproduction quantitative PCR RNA sperm motility Genetics Paulo Viana verfasserin aut Alberto Barros verfasserin aut Rosália Sá verfasserin aut Mário Sousa verfasserin aut Rute Pereira verfasserin aut In Genes MDPI AG, 2010 13(2022), 7, p 1291 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:13 year:2022 number:7, p 1291 https://doi.org/10.3390/genes13071291 kostenfrei https://doaj.org/article/6c41d9ba4f7b4fe39434e37147e0dbe1 kostenfrei https://www.mdpi.com/2073-4425/13/7/1291 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 7, p 1291 |
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10.3390/genes13071291 doi (DE-627)DOAJ030893909 (DE-599)DOAJ6c41d9ba4f7b4fe39434e37147e0dbe1 DE-627 ger DE-627 rakwb eng QH426-470 Carolina Silva verfasserin aut Further Insights on RNA Expression and Sperm Motility 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. gene expression male reproduction quantitative PCR RNA sperm motility Genetics Paulo Viana verfasserin aut Alberto Barros verfasserin aut Rosália Sá verfasserin aut Mário Sousa verfasserin aut Rute Pereira verfasserin aut In Genes MDPI AG, 2010 13(2022), 7, p 1291 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:13 year:2022 number:7, p 1291 https://doi.org/10.3390/genes13071291 kostenfrei https://doaj.org/article/6c41d9ba4f7b4fe39434e37147e0dbe1 kostenfrei https://www.mdpi.com/2073-4425/13/7/1291 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 7, p 1291 |
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Further Insights on RNA Expression and Sperm Motility |
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Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. |
abstractGer |
Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. |
abstract_unstemmed |
Asthenozoospermia is one of the main causes of male infertility and it is characterized by reduced sperm motility. Several mutations in genes that code for structural or functional constituents of the sperm have already been identified as known causes of asthenozoospermia. In contrast, the role of sperm RNA in regulating sperm motility is still not fully understood. Consequently, here we aim to contribute to the knowledge regarding the expression of sperm RNA, and ultimately, to provide further insights into its relationship with sperm motility. We investigated the expression of a group of mRNAs by using real-time PCR (<i<CATSPER3</i<, <i<CFAP44</i<, <i<CRHR1</i<, <i<HIP1</i<, <i<IQCG KRT34</i<, <i<LRRC6</i<, <i<QRICH2</i<, <i<RSPH6A</i<, <i<SPATA33</i< and <i<TEKT2</i<) and the highest score corresponding to the target miRNA for each mRNA in asthenozoospermic and normozoospermic individuals. We observed a reduced expression of all mRNAs and miRNAs in asthenozoospermic patients compared to controls, with a more accentuated reduction in patients with progressive sperm motility lower than 15%. Our work provides further insights regarding the role of RNA in regulating sperm motility. Further studies are required to determine how these genes and their corresponding miRNA act regarding sperm motility, particularly <i<KRT34</i< and <i<CRHR1</i<, which have not previously been seen to play a significant role in regulating sperm motility. |
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