Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the pr...
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Autor*in:	Jyh-Horng Sheu [verfasserIn] Yan-Ning Lee [verfasserIn] Chi-Jen Tai [verfasserIn] Tsong-Long Hwang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent

Übergeordnetes Werk:	In: Marine Drugs - MDPI AG, 2005, 11(2013), 8, Seite 2741-2750
Übergeordnetes Werk:	volume:11 ; year:2013 ; number:8 ; pages:2741-2750

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/md11082741

Katalog-ID:	DOAJ030937620

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allfieldsGer	10.3390/md11082741 doi (DE-627)DOAJ030937620 (DE-599)DOAJc18b8fd9123d48d6a8be609a08bbe46b DE-627 ger DE-627 rakwb eng QH301-705.5 Jyh-Horng Sheu verfasserin aut Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release. Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent Biology (General) Yan-Ning Lee verfasserin aut Chi-Jen Tai verfasserin aut Tsong-Long Hwang verfasserin aut In Marine Drugs MDPI AG, 2005 11(2013), 8, Seite 2741-2750 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:11 year:2013 number:8 pages:2741-2750 https://doi.org/10.3390/md11082741 kostenfrei https://doaj.org/article/c18b8fd9123d48d6a8be609a08bbe46b kostenfrei http://www.mdpi.com/1660-3397/11/8/2741 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 8 2741-2750
allfieldsSound	10.3390/md11082741 doi (DE-627)DOAJ030937620 (DE-599)DOAJc18b8fd9123d48d6a8be609a08bbe46b DE-627 ger DE-627 rakwb eng QH301-705.5 Jyh-Horng Sheu verfasserin aut Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release. Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent Biology (General) Yan-Ning Lee verfasserin aut Chi-Jen Tai verfasserin aut Tsong-Long Hwang verfasserin aut In Marine Drugs MDPI AG, 2005 11(2013), 8, Seite 2741-2750 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:11 year:2013 number:8 pages:2741-2750 https://doi.org/10.3390/md11082741 kostenfrei https://doaj.org/article/c18b8fd9123d48d6a8be609a08bbe46b kostenfrei http://www.mdpi.com/1660-3397/11/8/2741 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 8 2741-2750
language	English
source	In Marine Drugs 11(2013), 8, Seite 2741-2750 volume:11 year:2013 number:8 pages:2741-2750
sourceStr	In Marine Drugs 11(2013), 8, Seite 2741-2750 volume:11 year:2013 number:8 pages:2741-2750
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topic_facet	Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent Biology (General)
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container_title	Marine Drugs
authorswithroles_txt_mv	Jyh-Horng Sheu @@aut@@ Yan-Ning Lee @@aut@@ Chi-Jen Tai @@aut@@ Tsong-Long Hwang @@aut@@
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author	Jyh-Horng Sheu
spellingShingle	Jyh-Horng Sheu misc QH301-705.5 misc Cladiella krempfi misc eunicellin-based diterpenoid misc elastase misc anti-inflammatory agent misc Biology (General) Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
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topic_title	QH301-705.5 Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent
topic	misc QH301-705.5 misc Cladiella krempfi misc eunicellin-based diterpenoid misc elastase misc anti-inflammatory agent misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Cladiella krempfi misc eunicellin-based diterpenoid misc elastase misc anti-inflammatory agent misc Biology (General)
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title	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
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title_sort	krempfielins j-m, new eunicellin-based diterpenoids from the soft coral cladiella krempfi
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title_auth	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
abstract	New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
abstractGer	New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
abstract_unstemmed	New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
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title_short	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
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score	7.399351

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