Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity

Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported method for the inhibition of melanogenesis. Bec...
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Autor*in:	Te-Sheng Chang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	inhibitors melanogenesis tyrosinase

Übergeordnetes Werk:	In: Materials - MDPI AG, 2009, 5(2012), 9, Seite 1661-1685
Übergeordnetes Werk:	volume:5 ; year:2012 ; number:9 ; pages:1661-1685

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ma5091661

Katalog-ID:	DOAJ030960975

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author	Te-Sheng Chang
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title	Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
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title_sort	natural melanogenesis inhibitors acting through the down-regulation of tyrosinase activity
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title_auth	Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
abstract	Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported method for the inhibition of melanogenesis. Because of the cosmetically important issue of hyperpigmentation, there is a big demand for melanogenesis inhibitors. This encourages researchers to seek potent melanogenesis inhibitors for cosmetic uses. This article reviews melanogenesis inhibitors that have been recently discovered from natural sources. The reaction mechanisms of the inhibitors on tyrosinase activity are also discussed.
abstractGer	Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported method for the inhibition of melanogenesis. Because of the cosmetically important issue of hyperpigmentation, there is a big demand for melanogenesis inhibitors. This encourages researchers to seek potent melanogenesis inhibitors for cosmetic uses. This article reviews melanogenesis inhibitors that have been recently discovered from natural sources. The reaction mechanisms of the inhibitors on tyrosinase activity are also discussed.
abstract_unstemmed	Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported method for the inhibition of melanogenesis. Because of the cosmetically important issue of hyperpigmentation, there is a big demand for melanogenesis inhibitors. This encourages researchers to seek potent melanogenesis inhibitors for cosmetic uses. This article reviews melanogenesis inhibitors that have been recently discovered from natural sources. The reaction mechanisms of the inhibitors on tyrosinase activity are also discussed.
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title_short	Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
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Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity

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