Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters

The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to...
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Autor*in:	Melanie Rissmann [verfasserIn] Danny Noack [verfasserIn] Debby van Riel [verfasserIn] Katharina S. Schmitz [verfasserIn] Rory D. de Vries [verfasserIn] Peter van Run [verfasserIn] Mart M. Lamers [verfasserIn] Corine H. Geurts van Kessel [verfasserIn] Marion P. G. Koopmans [verfasserIn] Ron A. M. Fouchier [verfasserIn] Thijs Kuiken [verfasserIn] Bart L. Haagmans [verfasserIn] Barry Rockx [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	SARS-CoV-2 Omicron BA.1 Delta Syrian golden hamster pathology re-challenge

Übergeordnetes Werk:	In: Emerging Microbes and Infections - Taylor & Francis Group, 2013, 11(2022), 1, Seite 1778-1786
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:1 ; pages:1778-1786

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1080/22221751.2022.2095932

Katalog-ID:	DOAJ030971888

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allfieldsSound	10.1080/22221751.2022.2095932 doi (DE-627)DOAJ030971888 (DE-599)DOAJ930a4dfe4b8745bc9aec2b77ead50710 DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Melanie Rissmann verfasserin aut Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous infection. Here, we inoculated hamsters with Omicron BA.1 to evaluate pathogenicity and kinetics of viral shedding, compared to Delta (B.1.617.2) and to animals re-challenged with Omicron BA.1 after previous SARS-CoV-2 614G infection. Omicron BA.1 infected animals showed reduced clinical signs, pathological changes, and viral shedding, compared to Delta-infected animals, but still showed gross- and histopathological evidence of pneumonia. Pre-existing immunity reduced viral shedding and protected against pneumonia. Our data indicate that the observed decrease of disease severity is in part due to intrinsic properties of the Omicron BA.1 variant. SARS-CoV-2 Omicron BA.1 Delta Syrian golden hamster pathology re-challenge Infectious and parasitic diseases Microbiology Danny Noack verfasserin aut Debby van Riel verfasserin aut Katharina S. Schmitz verfasserin aut Rory D. de Vries verfasserin aut Peter van Run verfasserin aut Mart M. Lamers verfasserin aut Corine H. Geurts van Kessel verfasserin aut Marion P. G. Koopmans verfasserin aut Ron A. M. Fouchier verfasserin aut Thijs Kuiken verfasserin aut Bart L. Haagmans verfasserin aut Barry Rockx verfasserin aut In Emerging Microbes and Infections Taylor & Francis Group, 2013 11(2022), 1, Seite 1778-1786 (DE-627)726120715 (DE-600)2681359-2 22221751 nnns volume:11 year:2022 number:1 pages:1778-1786 https://doi.org/10.1080/22221751.2022.2095932 kostenfrei https://doaj.org/article/930a4dfe4b8745bc9aec2b77ead50710 kostenfrei https://www.tandfonline.com/doi/10.1080/22221751.2022.2095932 kostenfrei https://doaj.org/toc/2222-1751 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1 1778-1786
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callnumber-first	R - Medicine
author	Melanie Rissmann
spellingShingle	Melanie Rissmann misc RC109-216 misc QR1-502 misc SARS-CoV-2 misc Omicron BA.1 misc Delta misc Syrian golden hamster misc pathology misc re-challenge misc Infectious and parasitic diseases misc Microbiology Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters
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topic_title	RC109-216 QR1-502 Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters SARS-CoV-2 Omicron BA.1 Delta Syrian golden hamster pathology re-challenge
topic	misc RC109-216 misc QR1-502 misc SARS-CoV-2 misc Omicron BA.1 misc Delta misc Syrian golden hamster misc pathology misc re-challenge misc Infectious and parasitic diseases misc Microbiology
topic_unstemmed	misc RC109-216 misc QR1-502 misc SARS-CoV-2 misc Omicron BA.1 misc Delta misc Syrian golden hamster misc pathology misc re-challenge misc Infectious and parasitic diseases misc Microbiology
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title	Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters
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title_full	Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters
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author_browse	Melanie Rissmann Danny Noack Debby van Riel Katharina S. Schmitz Rory D. de Vries Peter van Run Mart M. Lamers Corine H. Geurts van Kessel Marion P. G. Koopmans Ron A. M. Fouchier Thijs Kuiken Bart L. Haagmans Barry Rockx
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title_sort	pulmonary lesions following inoculation with the sars-cov-2 omicron ba.1 (b.1.1.529) variant in syrian golden hamsters
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title_auth	Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters
abstract	The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous infection. Here, we inoculated hamsters with Omicron BA.1 to evaluate pathogenicity and kinetics of viral shedding, compared to Delta (B.1.617.2) and to animals re-challenged with Omicron BA.1 after previous SARS-CoV-2 614G infection. Omicron BA.1 infected animals showed reduced clinical signs, pathological changes, and viral shedding, compared to Delta-infected animals, but still showed gross- and histopathological evidence of pneumonia. Pre-existing immunity reduced viral shedding and protected against pneumonia. Our data indicate that the observed decrease of disease severity is in part due to intrinsic properties of the Omicron BA.1 variant.
abstractGer	The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous infection. Here, we inoculated hamsters with Omicron BA.1 to evaluate pathogenicity and kinetics of viral shedding, compared to Delta (B.1.617.2) and to animals re-challenged with Omicron BA.1 after previous SARS-CoV-2 614G infection. Omicron BA.1 infected animals showed reduced clinical signs, pathological changes, and viral shedding, compared to Delta-infected animals, but still showed gross- and histopathological evidence of pneumonia. Pre-existing immunity reduced viral shedding and protected against pneumonia. Our data indicate that the observed decrease of disease severity is in part due to intrinsic properties of the Omicron BA.1 variant.
abstract_unstemmed	The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous infection. Here, we inoculated hamsters with Omicron BA.1 to evaluate pathogenicity and kinetics of viral shedding, compared to Delta (B.1.617.2) and to animals re-challenged with Omicron BA.1 after previous SARS-CoV-2 614G infection. Omicron BA.1 infected animals showed reduced clinical signs, pathological changes, and viral shedding, compared to Delta-infected animals, but still showed gross- and histopathological evidence of pneumonia. Pre-existing immunity reduced viral shedding and protected against pneumonia. Our data indicate that the observed decrease of disease severity is in part due to intrinsic properties of the Omicron BA.1 variant.
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title_short	Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters
url	https://doi.org/10.1080/22221751.2022.2095932 https://doaj.org/article/930a4dfe4b8745bc9aec2b77ead50710 https://www.tandfonline.com/doi/10.1080/22221751.2022.2095932 https://doaj.org/toc/2222-1751
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Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters

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