Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i<

The present investigation on chemical constituents of the soft coral <i<Sarcophyton cherbonnieri</i< resulted in the isolation of seven new cembranoids, cherbonolides F–L (<b<1</b<–<b<7</b<). The chemical structures of <b<1</b<–<b<7</b< wer...
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Gespeichert in:

Autor*in:	Chia-Chi Peng [verfasserIn] Chiung-Yao Huang [verfasserIn] Atallah F. Ahmed [verfasserIn] Tsong-Long Hwang [verfasserIn] Jyh-Horng Sheu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	cembranoid anti-inflammatory activity elastase release superoxide anion generation

Übergeordnetes Werk:	In: Marine Drugs - MDPI AG, 2005, 18(2020), 11, p 573
Übergeordnetes Werk:	volume:18 ; year:2020 ; number:11, p 573

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/md18110573

Katalog-ID:	DOAJ030972930

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allfieldsSound	10.3390/md18110573 doi (DE-627)DOAJ030972930 (DE-599)DOAJ241df3a6edbd4e46bd9d4c151f938461 DE-627 ger DE-627 rakwb eng QH301-705.5 Chia-Chi Peng verfasserin aut Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i< 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present investigation on chemical constituents of the soft coral <i<Sarcophyton cherbonnieri</i< resulted in the isolation of seven new cembranoids, cherbonolides F–L (<b<1</b<–<b<7</b<). The chemical structures of <b<1</b<–<b<7</b< were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of <b<1</b<–<b<7</b< against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward <i<N</i<-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (<b<2</b<) and cherbonolide H (<b<3</b<) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively. <i<Sarcophyton cherbonnieri</i< cembranoid anti-inflammatory activity elastase release superoxide anion generation Biology (General) Chiung-Yao Huang verfasserin aut Atallah F. Ahmed verfasserin aut Tsong-Long Hwang verfasserin aut Jyh-Horng Sheu verfasserin aut In Marine Drugs MDPI AG, 2005 18(2020), 11, p 573 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:18 year:2020 number:11, p 573 https://doi.org/10.3390/md18110573 kostenfrei https://doaj.org/article/241df3a6edbd4e46bd9d4c151f938461 kostenfrei https://www.mdpi.com/1660-3397/18/11/573 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 11, p 573
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callnumber-first	Q - Science
author	Chia-Chi Peng
spellingShingle	Chia-Chi Peng misc QH301-705.5 misc <i<Sarcophyton cherbonnieri</i< misc cembranoid misc anti-inflammatory activity misc elastase release misc superoxide anion generation misc Biology (General) Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i<
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topic_title	QH301-705.5 Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i< <i<Sarcophyton cherbonnieri</i< cembranoid anti-inflammatory activity elastase release superoxide anion generation
topic	misc QH301-705.5 misc <i<Sarcophyton cherbonnieri</i< misc cembranoid misc anti-inflammatory activity misc elastase release misc superoxide anion generation misc Biology (General)
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title	Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i<
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title_full	Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i<
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title_sort	anti-inflammatory cembranoids from a formosa soft coral <i<sarcophyton cherbonnieri</i<
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title_auth	Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i<
abstract	The present investigation on chemical constituents of the soft coral <i<Sarcophyton cherbonnieri</i< resulted in the isolation of seven new cembranoids, cherbonolides F–L (<b<1</b<–<b<7</b<). The chemical structures of <b<1</b<–<b<7</b< were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of <b<1</b<–<b<7</b< against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward <i<N</i<-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (<b<2</b<) and cherbonolide H (<b<3</b<) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively.
abstractGer	The present investigation on chemical constituents of the soft coral <i<Sarcophyton cherbonnieri</i< resulted in the isolation of seven new cembranoids, cherbonolides F–L (<b<1</b<–<b<7</b<). The chemical structures of <b<1</b<–<b<7</b< were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of <b<1</b<–<b<7</b< against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward <i<N</i<-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (<b<2</b<) and cherbonolide H (<b<3</b<) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively.
abstract_unstemmed	The present investigation on chemical constituents of the soft coral <i<Sarcophyton cherbonnieri</i< resulted in the isolation of seven new cembranoids, cherbonolides F–L (<b<1</b<–<b<7</b<). The chemical structures of <b<1</b<–<b<7</b< were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of <b<1</b<–<b<7</b< against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward <i<N</i<-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (<b<2</b<) and cherbonolide H (<b<3</b<) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively.
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title_short	Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i<
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Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i<Sarcophyton cherbonnieri</i<

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