The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes
The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats...
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| Autor*in: |
S. V. Logvinov [verfasserIn] E. Yu. Varakuta [verfasserIn] A. V. Potapov [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch |
| Erschienen: |
2002 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Бюллетень сибирской медицины - Siberian State Medical University (Tomsk), 2016, 1(2002), 2, Seite 47-52 |
|---|---|
| Übergeordnetes Werk: |
volume:1 ; year:2002 ; number:2 ; pages:47-52 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.20538/1682-0363-2002-2-47-52 |
|---|
| Katalog-ID: |
DOAJ030992214 |
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| 520 | |a The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. | ||
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10.20538/1682-0363-2002-2-47-52 doi (DE-627)DOAJ030992214 (DE-599)DOAJda489003ab6c4a3ca60ff240f894c989 DE-627 ger DE-627 rakwb eng rus S. V. Logvinov verfasserin aut The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. нейросенсорные клетки сахарный диабет свет Medicine R E. Yu. Varakuta verfasserin aut A. V. Potapov verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 1(2002), 2, Seite 47-52 (DE-627)1760628204 18193684 nnns volume:1 year:2002 number:2 pages:47-52 https://doi.org/10.20538/1682-0363-2002-2-47-52 kostenfrei https://doaj.org/article/da489003ab6c4a3ca60ff240f894c989 kostenfrei https://bulletin.ssmu.ru/jour/article/view/3949 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 1 2002 2 47-52 |
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10.20538/1682-0363-2002-2-47-52 doi (DE-627)DOAJ030992214 (DE-599)DOAJda489003ab6c4a3ca60ff240f894c989 DE-627 ger DE-627 rakwb eng rus S. V. Logvinov verfasserin aut The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. нейросенсорные клетки сахарный диабет свет Medicine R E. Yu. Varakuta verfasserin aut A. V. Potapov verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 1(2002), 2, Seite 47-52 (DE-627)1760628204 18193684 nnns volume:1 year:2002 number:2 pages:47-52 https://doi.org/10.20538/1682-0363-2002-2-47-52 kostenfrei https://doaj.org/article/da489003ab6c4a3ca60ff240f894c989 kostenfrei https://bulletin.ssmu.ru/jour/article/view/3949 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 1 2002 2 47-52 |
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10.20538/1682-0363-2002-2-47-52 doi (DE-627)DOAJ030992214 (DE-599)DOAJda489003ab6c4a3ca60ff240f894c989 DE-627 ger DE-627 rakwb eng rus S. V. Logvinov verfasserin aut The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. нейросенсорные клетки сахарный диабет свет Medicine R E. Yu. Varakuta verfasserin aut A. V. Potapov verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 1(2002), 2, Seite 47-52 (DE-627)1760628204 18193684 nnns volume:1 year:2002 number:2 pages:47-52 https://doi.org/10.20538/1682-0363-2002-2-47-52 kostenfrei https://doaj.org/article/da489003ab6c4a3ca60ff240f894c989 kostenfrei https://bulletin.ssmu.ru/jour/article/view/3949 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 1 2002 2 47-52 |
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The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes нейросенсорные клетки сахарный диабет свет |
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The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
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The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
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S. V. Logvinov |
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сharacter and development of photoreceptors photodegeneration combined with alloxan diabetes |
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The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes |
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The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. |
| abstractGer |
The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. |
| abstract_unstemmed |
The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect. |
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