Recent Advances and Future Perspectives in Polymer-Based Nanovaccines

Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Nov...
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Autor*in:	Natassa Pippa [verfasserIn] Maria Gazouli [verfasserIn] Stergios Pispas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	polymers biodegradable polymers poly(lactic-co-glycolic acid) (PLGA) nanoparticles nanovaccines adjuvants

Übergeordnetes Werk:	In: Vaccines - MDPI AG, 2013, 9(2021), 6, p 558
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:6, p 558

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/vaccines9060558

Katalog-ID:	DOAJ031021042

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spelling	10.3390/vaccines9060558 doi (DE-627)DOAJ031021042 (DE-599)DOAJ6c7d6bf8bfc34605b5ec0197f58d345b DE-627 ger DE-627 rakwb eng Natassa Pippa verfasserin aut Recent Advances and Future Perspectives in Polymer-Based Nanovaccines 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry. polymers biodegradable polymers poly(lactic-co-glycolic acid) (PLGA) nanoparticles nanovaccines adjuvants Medicine R Maria Gazouli verfasserin aut Stergios Pispas verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 6, p 558 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:6, p 558 https://doi.org/10.3390/vaccines9060558 kostenfrei https://doaj.org/article/6c7d6bf8bfc34605b5ec0197f58d345b kostenfrei https://www.mdpi.com/2076-393X/9/6/558 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 6, p 558
allfields_unstemmed	10.3390/vaccines9060558 doi (DE-627)DOAJ031021042 (DE-599)DOAJ6c7d6bf8bfc34605b5ec0197f58d345b DE-627 ger DE-627 rakwb eng Natassa Pippa verfasserin aut Recent Advances and Future Perspectives in Polymer-Based Nanovaccines 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry. polymers biodegradable polymers poly(lactic-co-glycolic acid) (PLGA) nanoparticles nanovaccines adjuvants Medicine R Maria Gazouli verfasserin aut Stergios Pispas verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 6, p 558 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:6, p 558 https://doi.org/10.3390/vaccines9060558 kostenfrei https://doaj.org/article/6c7d6bf8bfc34605b5ec0197f58d345b kostenfrei https://www.mdpi.com/2076-393X/9/6/558 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 6, p 558
allfieldsGer	10.3390/vaccines9060558 doi (DE-627)DOAJ031021042 (DE-599)DOAJ6c7d6bf8bfc34605b5ec0197f58d345b DE-627 ger DE-627 rakwb eng Natassa Pippa verfasserin aut Recent Advances and Future Perspectives in Polymer-Based Nanovaccines 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry. polymers biodegradable polymers poly(lactic-co-glycolic acid) (PLGA) nanoparticles nanovaccines adjuvants Medicine R Maria Gazouli verfasserin aut Stergios Pispas verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 6, p 558 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:6, p 558 https://doi.org/10.3390/vaccines9060558 kostenfrei https://doaj.org/article/6c7d6bf8bfc34605b5ec0197f58d345b kostenfrei https://www.mdpi.com/2076-393X/9/6/558 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 6, p 558
allfieldsSound	10.3390/vaccines9060558 doi (DE-627)DOAJ031021042 (DE-599)DOAJ6c7d6bf8bfc34605b5ec0197f58d345b DE-627 ger DE-627 rakwb eng Natassa Pippa verfasserin aut Recent Advances and Future Perspectives in Polymer-Based Nanovaccines 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry. polymers biodegradable polymers poly(lactic-co-glycolic acid) (PLGA) nanoparticles nanovaccines adjuvants Medicine R Maria Gazouli verfasserin aut Stergios Pispas verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 6, p 558 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:6, p 558 https://doi.org/10.3390/vaccines9060558 kostenfrei https://doaj.org/article/6c7d6bf8bfc34605b5ec0197f58d345b kostenfrei https://www.mdpi.com/2076-393X/9/6/558 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 6, p 558
language	English
source	In Vaccines 9(2021), 6, p 558 volume:9 year:2021 number:6, p 558
sourceStr	In Vaccines 9(2021), 6, p 558 volume:9 year:2021 number:6, p 558
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topic_facet	polymers biodegradable polymers poly(lactic-co-glycolic acid) (PLGA) nanoparticles nanovaccines adjuvants Medicine R
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container_title	Vaccines
authorswithroles_txt_mv	Natassa Pippa @@aut@@ Maria Gazouli @@aut@@ Stergios Pispas @@aut@@
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author	Natassa Pippa
spellingShingle	Natassa Pippa misc polymers misc biodegradable polymers misc poly(lactic-co-glycolic acid) (PLGA) misc nanoparticles misc nanovaccines misc adjuvants misc Medicine misc R Recent Advances and Future Perspectives in Polymer-Based Nanovaccines
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topic_title	Recent Advances and Future Perspectives in Polymer-Based Nanovaccines polymers biodegradable polymers poly(lactic-co-glycolic acid) (PLGA) nanoparticles nanovaccines adjuvants
topic	misc polymers misc biodegradable polymers misc poly(lactic-co-glycolic acid) (PLGA) misc nanoparticles misc nanovaccines misc adjuvants misc Medicine misc R
topic_unstemmed	misc polymers misc biodegradable polymers misc poly(lactic-co-glycolic acid) (PLGA) misc nanoparticles misc nanovaccines misc adjuvants misc Medicine misc R
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title	Recent Advances and Future Perspectives in Polymer-Based Nanovaccines
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title_sort	recent advances and future perspectives in polymer-based nanovaccines
title_auth	Recent Advances and Future Perspectives in Polymer-Based Nanovaccines
abstract	Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry.
abstractGer	Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry.
abstract_unstemmed	Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry.
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title_short	Recent Advances and Future Perspectives in Polymer-Based Nanovaccines
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