Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators

Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results...
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Autor*in:	Haitao Sun [verfasserIn] Tianzhu Yu [verfasserIn] Xin Li [verfasserIn] Yangyang Lei [verfasserIn] Jianke Li [verfasserIn] Xiuhui Wang [verfasserIn] Peike Peng [verfasserIn] Dalong Ni [verfasserIn] Xiaolin Wang [verfasserIn] Yu Luo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy

Übergeordnetes Werk:	In: Journal of Nanobiotechnology - BMC, 2003, 19(2021), 1, Seite 17
Übergeordnetes Werk:	volume:19 ; year:2021 ; number:1 ; pages:17

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12951-021-01197-5

Katalog-ID:	DOAJ031233600

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allfields	10.1186/s12951-021-01197-5 doi (DE-627)DOAJ031233600 (DE-599)DOAJ345e55a7aa8a4e3a84d7d57548306f46 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Haitao Sun verfasserin aut Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy Biotechnology Medical technology Tianzhu Yu verfasserin aut Xin Li verfasserin aut Yangyang Lei verfasserin aut Jianke Li verfasserin aut Xiuhui Wang verfasserin aut Peike Peng verfasserin aut Dalong Ni verfasserin aut Xiaolin Wang verfasserin aut Yu Luo verfasserin aut In Journal of Nanobiotechnology BMC, 2003 19(2021), 1, Seite 17 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:19 year:2021 number:1 pages:17 https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/article/345e55a7aa8a4e3a84d7d57548306f46 kostenfrei https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 17
spelling	10.1186/s12951-021-01197-5 doi (DE-627)DOAJ031233600 (DE-599)DOAJ345e55a7aa8a4e3a84d7d57548306f46 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Haitao Sun verfasserin aut Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy Biotechnology Medical technology Tianzhu Yu verfasserin aut Xin Li verfasserin aut Yangyang Lei verfasserin aut Jianke Li verfasserin aut Xiuhui Wang verfasserin aut Peike Peng verfasserin aut Dalong Ni verfasserin aut Xiaolin Wang verfasserin aut Yu Luo verfasserin aut In Journal of Nanobiotechnology BMC, 2003 19(2021), 1, Seite 17 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:19 year:2021 number:1 pages:17 https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/article/345e55a7aa8a4e3a84d7d57548306f46 kostenfrei https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 17
allfields_unstemmed	10.1186/s12951-021-01197-5 doi (DE-627)DOAJ031233600 (DE-599)DOAJ345e55a7aa8a4e3a84d7d57548306f46 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Haitao Sun verfasserin aut Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy Biotechnology Medical technology Tianzhu Yu verfasserin aut Xin Li verfasserin aut Yangyang Lei verfasserin aut Jianke Li verfasserin aut Xiuhui Wang verfasserin aut Peike Peng verfasserin aut Dalong Ni verfasserin aut Xiaolin Wang verfasserin aut Yu Luo verfasserin aut In Journal of Nanobiotechnology BMC, 2003 19(2021), 1, Seite 17 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:19 year:2021 number:1 pages:17 https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/article/345e55a7aa8a4e3a84d7d57548306f46 kostenfrei https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 17
allfieldsGer	10.1186/s12951-021-01197-5 doi (DE-627)DOAJ031233600 (DE-599)DOAJ345e55a7aa8a4e3a84d7d57548306f46 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Haitao Sun verfasserin aut Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy Biotechnology Medical technology Tianzhu Yu verfasserin aut Xin Li verfasserin aut Yangyang Lei verfasserin aut Jianke Li verfasserin aut Xiuhui Wang verfasserin aut Peike Peng verfasserin aut Dalong Ni verfasserin aut Xiaolin Wang verfasserin aut Yu Luo verfasserin aut In Journal of Nanobiotechnology BMC, 2003 19(2021), 1, Seite 17 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:19 year:2021 number:1 pages:17 https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/article/345e55a7aa8a4e3a84d7d57548306f46 kostenfrei https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 17
allfieldsSound	10.1186/s12951-021-01197-5 doi (DE-627)DOAJ031233600 (DE-599)DOAJ345e55a7aa8a4e3a84d7d57548306f46 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Haitao Sun verfasserin aut Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy Biotechnology Medical technology Tianzhu Yu verfasserin aut Xin Li verfasserin aut Yangyang Lei verfasserin aut Jianke Li verfasserin aut Xiuhui Wang verfasserin aut Peike Peng verfasserin aut Dalong Ni verfasserin aut Xiaolin Wang verfasserin aut Yu Luo verfasserin aut In Journal of Nanobiotechnology BMC, 2003 19(2021), 1, Seite 17 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:19 year:2021 number:1 pages:17 https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/article/345e55a7aa8a4e3a84d7d57548306f46 kostenfrei https://doi.org/10.1186/s12951-021-01197-5 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 17
language	English
source	In Journal of Nanobiotechnology 19(2021), 1, Seite 17 volume:19 year:2021 number:1 pages:17
sourceStr	In Journal of Nanobiotechnology 19(2021), 1, Seite 17 volume:19 year:2021 number:1 pages:17
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy Biotechnology Medical technology
isfreeaccess_bool	true
container_title	Journal of Nanobiotechnology
authorswithroles_txt_mv	Haitao Sun @@aut@@ Tianzhu Yu @@aut@@ Xin Li @@aut@@ Yangyang Lei @@aut@@ Jianke Li @@aut@@ Xiuhui Wang @@aut@@ Peike Peng @@aut@@ Dalong Ni @@aut@@ Xiaolin Wang @@aut@@ Yu Luo @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	362770328
id	DOAJ031233600
language_de	englisch
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Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. 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callnumber-first	T - Technology
author	Haitao Sun
spellingShingle	Haitao Sun misc TP248.13-248.65 misc R855-855.5 misc Second near-infrared light misc Nanostimulators misc Precise controlled release misc Cancer immunotherapy misc Photothermal therapy misc Biotechnology misc Medical technology Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators
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topic_title	TP248.13-248.65 R855-855.5 Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators Second near-infrared light Nanostimulators Precise controlled release Cancer immunotherapy Photothermal therapy
topic	misc TP248.13-248.65 misc R855-855.5 misc Second near-infrared light misc Nanostimulators misc Precise controlled release misc Cancer immunotherapy misc Photothermal therapy misc Biotechnology misc Medical technology
topic_unstemmed	misc TP248.13-248.65 misc R855-855.5 misc Second near-infrared light misc Nanostimulators misc Precise controlled release misc Cancer immunotherapy misc Photothermal therapy misc Biotechnology misc Medical technology
topic_browse	misc TP248.13-248.65 misc R855-855.5 misc Second near-infrared light misc Nanostimulators misc Precise controlled release misc Cancer immunotherapy misc Photothermal therapy misc Biotechnology misc Medical technology
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title	Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators
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title_full	Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators
author_sort	Haitao Sun
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author_browse	Haitao Sun Tianzhu Yu Xin Li Yangyang Lei Jianke Li Xiuhui Wang Peike Peng Dalong Ni Xiaolin Wang Yu Luo
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title_sort	second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators
callnumber	TP248.13-248.65
title_auth	Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators
abstract	Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract
abstractGer	Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract
abstract_unstemmed	Abstract Background The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune system response step by step is one of the most potent cancer treatment strategies for improving the sensitivity of immunotherapy response. Results Here, a composite nanostimulator (CNS) was constructed for the release of second near-infrared (NIR-II) photothermal-mediated immune agents, thereby achieving spatiotemporally controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an outer shell and are internally loaded with a NIR-II photothermal agent, copper sulfide (CuS), toll-like receptor-9 (TLR-9) agonist, cytosine-phospho-guanine oligodeoxynucleotides, and programmed death-ligand 1 (PD-L1) inhibitors (JQ1). Following NIR-II photoirradiation, CuS enabled the rapid elevation of localized temperature, achieving tumor ablation and induction of immunogenic cell death (ICD) as well as disruption of the lipid shell, enabling the precise release of two immune-therapeutical drugs in the tumor region. Combining ICD, TLR-9 stimulation, and inhibited expression of PD-L1 allows the subsequent enhancement of dendritic cell maturation and increases infiltration of cytotoxic T lymphocytes, facilitating regional antitumor immune responses. Conclusion CNS nanoparticle-mediated photothermal-synergized immunotherapy efficiently suppressed the growth of primary and distant tumors in two mouse models and prevented pulmonary metastasis. This study thus provides a novel sight into photo-controllably safe and efficient immunotherapy. Graphical Abstract
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title_short	Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators
url	https://doi.org/10.1186/s12951-021-01197-5 https://doaj.org/article/345e55a7aa8a4e3a84d7d57548306f46 https://doaj.org/toc/1477-3155
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author2	Tianzhu Yu Xin Li Yangyang Lei Jianke Li Xiuhui Wang Peike Peng Dalong Ni Xiaolin Wang Yu Luo
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up_date	2024-07-03T19:29:14.271Z
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