Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer

Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yue Zhao [verfasserIn] Huimin Sun [verfasserIn] Jianzhong Zheng [verfasserIn] Chen Shao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Prostate cancer m6A RNA methylation tumour microenvironment prognosis immune cell infiltration

Übergeordnetes Werk:	In: Artificial Cells, Nanomedicine, and Biotechnology - Taylor & Francis Group, 2019, 49(2021), 1, Seite 407-435
Übergeordnetes Werk:	volume:49 ; year:2021 ; number:1 ; pages:407-435

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/21691401.2021.1912759

Katalog-ID:	DOAJ031329837

Internformat


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650		4	\|a Prostate cancer
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allfields	10.1080/21691401.2021.1912759 doi (DE-627)DOAJ031329837 (DE-599)DOAJf243136ddc914c678b7501af0424e709 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Yue Zhao verfasserin aut Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients. Prostate cancer m6A RNA methylation tumour microenvironment prognosis immune cell infiltration Biotechnology Medical technology Huimin Sun verfasserin aut Jianzhong Zheng verfasserin aut Chen Shao verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 49(2021), 1, Seite 407-435 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:49 year:2021 number:1 pages:407-435 https://doi.org/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/article/f243136ddc914c678b7501af0424e709 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2021 1 407-435
spelling	10.1080/21691401.2021.1912759 doi (DE-627)DOAJ031329837 (DE-599)DOAJf243136ddc914c678b7501af0424e709 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Yue Zhao verfasserin aut Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients. Prostate cancer m6A RNA methylation tumour microenvironment prognosis immune cell infiltration Biotechnology Medical technology Huimin Sun verfasserin aut Jianzhong Zheng verfasserin aut Chen Shao verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 49(2021), 1, Seite 407-435 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:49 year:2021 number:1 pages:407-435 https://doi.org/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/article/f243136ddc914c678b7501af0424e709 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2021 1 407-435
allfields_unstemmed	10.1080/21691401.2021.1912759 doi (DE-627)DOAJ031329837 (DE-599)DOAJf243136ddc914c678b7501af0424e709 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Yue Zhao verfasserin aut Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients. Prostate cancer m6A RNA methylation tumour microenvironment prognosis immune cell infiltration Biotechnology Medical technology Huimin Sun verfasserin aut Jianzhong Zheng verfasserin aut Chen Shao verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 49(2021), 1, Seite 407-435 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:49 year:2021 number:1 pages:407-435 https://doi.org/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/article/f243136ddc914c678b7501af0424e709 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2021 1 407-435
allfieldsGer	10.1080/21691401.2021.1912759 doi (DE-627)DOAJ031329837 (DE-599)DOAJf243136ddc914c678b7501af0424e709 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Yue Zhao verfasserin aut Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients. Prostate cancer m6A RNA methylation tumour microenvironment prognosis immune cell infiltration Biotechnology Medical technology Huimin Sun verfasserin aut Jianzhong Zheng verfasserin aut Chen Shao verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 49(2021), 1, Seite 407-435 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:49 year:2021 number:1 pages:407-435 https://doi.org/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/article/f243136ddc914c678b7501af0424e709 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2021 1 407-435
allfieldsSound	10.1080/21691401.2021.1912759 doi (DE-627)DOAJ031329837 (DE-599)DOAJf243136ddc914c678b7501af0424e709 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Yue Zhao verfasserin aut Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients. Prostate cancer m6A RNA methylation tumour microenvironment prognosis immune cell infiltration Biotechnology Medical technology Huimin Sun verfasserin aut Jianzhong Zheng verfasserin aut Chen Shao verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 49(2021), 1, Seite 407-435 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:49 year:2021 number:1 pages:407-435 https://doi.org/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/article/f243136ddc914c678b7501af0424e709 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2021.1912759 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2021 1 407-435
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callnumber-first	T - Technology
author	Yue Zhao
spellingShingle	Yue Zhao misc TP248.13-248.65 misc R855-855.5 misc Prostate cancer misc m6A RNA methylation misc tumour microenvironment misc prognosis misc immune cell infiltration misc Biotechnology misc Medical technology Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer
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topic_title	TP248.13-248.65 R855-855.5 Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer Prostate cancer m6A RNA methylation tumour microenvironment prognosis immune cell infiltration
topic	misc TP248.13-248.65 misc R855-855.5 misc Prostate cancer misc m6A RNA methylation misc tumour microenvironment misc prognosis misc immune cell infiltration misc Biotechnology misc Medical technology
topic_unstemmed	misc TP248.13-248.65 misc R855-855.5 misc Prostate cancer misc m6A RNA methylation misc tumour microenvironment misc prognosis misc immune cell infiltration misc Biotechnology misc Medical technology
topic_browse	misc TP248.13-248.65 misc R855-855.5 misc Prostate cancer misc m6A RNA methylation misc tumour microenvironment misc prognosis misc immune cell infiltration misc Biotechnology misc Medical technology
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title	Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer
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title_full	Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer
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title_sort	analysis of rna m6a methylation regulators and tumour immune cell infiltration characterization in prostate cancer
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title_auth	Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer
abstract	Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients.
abstractGer	Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients.
abstract_unstemmed	Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients.
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title_short	Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer
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Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer

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