Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus
Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore,...
Ausführliche Beschreibung
Autor*in: |
Yulong Wang [verfasserIn] Nan Jiang [verfasserIn] Linjin Fan [verfasserIn] Li Gao [verfasserIn] Kai Li [verfasserIn] Yulong Gao [verfasserIn] Xinxin Niu [verfasserIn] Wenying Zhang [verfasserIn] Hongyu Cui [verfasserIn] Aijing Liu [verfasserIn] Qing Pan [verfasserIn] Changjun Liu [verfasserIn] Yanping Zhang [verfasserIn] Xiaomei Wang [verfasserIn] Xiaole Qi [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Vaccines - MDPI AG, 2013, 9(2021), 2, p 142 |
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Übergeordnetes Werk: |
volume:9 ; year:2021 ; number:2, p 142 |
Links: |
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DOI / URN: |
10.3390/vaccines9020142 |
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Katalog-ID: |
DOAJ031424600 |
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10.3390/vaccines9020142 doi (DE-627)DOAJ031424600 (DE-599)DOAJd76e4f928b05400e8f899eb2b62f4de8 DE-627 ger DE-627 rakwb eng Yulong Wang verfasserin aut Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. novel variant infectious bursal disease virus vaccine viral-like particle Medicine R Nan Jiang verfasserin aut Linjin Fan verfasserin aut Li Gao verfasserin aut Kai Li verfasserin aut Yulong Gao verfasserin aut Xinxin Niu verfasserin aut Wenying Zhang verfasserin aut Hongyu Cui verfasserin aut Aijing Liu verfasserin aut Qing Pan verfasserin aut Changjun Liu verfasserin aut Yanping Zhang verfasserin aut Xiaomei Wang verfasserin aut Xiaole Qi verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 2, p 142 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:2, p 142 https://doi.org/10.3390/vaccines9020142 kostenfrei https://doaj.org/article/d76e4f928b05400e8f899eb2b62f4de8 kostenfrei https://www.mdpi.com/2076-393X/9/2/142 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 2, p 142 |
spelling |
10.3390/vaccines9020142 doi (DE-627)DOAJ031424600 (DE-599)DOAJd76e4f928b05400e8f899eb2b62f4de8 DE-627 ger DE-627 rakwb eng Yulong Wang verfasserin aut Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. novel variant infectious bursal disease virus vaccine viral-like particle Medicine R Nan Jiang verfasserin aut Linjin Fan verfasserin aut Li Gao verfasserin aut Kai Li verfasserin aut Yulong Gao verfasserin aut Xinxin Niu verfasserin aut Wenying Zhang verfasserin aut Hongyu Cui verfasserin aut Aijing Liu verfasserin aut Qing Pan verfasserin aut Changjun Liu verfasserin aut Yanping Zhang verfasserin aut Xiaomei Wang verfasserin aut Xiaole Qi verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 2, p 142 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:2, p 142 https://doi.org/10.3390/vaccines9020142 kostenfrei https://doaj.org/article/d76e4f928b05400e8f899eb2b62f4de8 kostenfrei https://www.mdpi.com/2076-393X/9/2/142 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 2, p 142 |
allfields_unstemmed |
10.3390/vaccines9020142 doi (DE-627)DOAJ031424600 (DE-599)DOAJd76e4f928b05400e8f899eb2b62f4de8 DE-627 ger DE-627 rakwb eng Yulong Wang verfasserin aut Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. novel variant infectious bursal disease virus vaccine viral-like particle Medicine R Nan Jiang verfasserin aut Linjin Fan verfasserin aut Li Gao verfasserin aut Kai Li verfasserin aut Yulong Gao verfasserin aut Xinxin Niu verfasserin aut Wenying Zhang verfasserin aut Hongyu Cui verfasserin aut Aijing Liu verfasserin aut Qing Pan verfasserin aut Changjun Liu verfasserin aut Yanping Zhang verfasserin aut Xiaomei Wang verfasserin aut Xiaole Qi verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 2, p 142 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:2, p 142 https://doi.org/10.3390/vaccines9020142 kostenfrei https://doaj.org/article/d76e4f928b05400e8f899eb2b62f4de8 kostenfrei https://www.mdpi.com/2076-393X/9/2/142 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 2, p 142 |
allfieldsGer |
10.3390/vaccines9020142 doi (DE-627)DOAJ031424600 (DE-599)DOAJd76e4f928b05400e8f899eb2b62f4de8 DE-627 ger DE-627 rakwb eng Yulong Wang verfasserin aut Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. novel variant infectious bursal disease virus vaccine viral-like particle Medicine R Nan Jiang verfasserin aut Linjin Fan verfasserin aut Li Gao verfasserin aut Kai Li verfasserin aut Yulong Gao verfasserin aut Xinxin Niu verfasserin aut Wenying Zhang verfasserin aut Hongyu Cui verfasserin aut Aijing Liu verfasserin aut Qing Pan verfasserin aut Changjun Liu verfasserin aut Yanping Zhang verfasserin aut Xiaomei Wang verfasserin aut Xiaole Qi verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 2, p 142 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:2, p 142 https://doi.org/10.3390/vaccines9020142 kostenfrei https://doaj.org/article/d76e4f928b05400e8f899eb2b62f4de8 kostenfrei https://www.mdpi.com/2076-393X/9/2/142 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 2, p 142 |
allfieldsSound |
10.3390/vaccines9020142 doi (DE-627)DOAJ031424600 (DE-599)DOAJd76e4f928b05400e8f899eb2b62f4de8 DE-627 ger DE-627 rakwb eng Yulong Wang verfasserin aut Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. novel variant infectious bursal disease virus vaccine viral-like particle Medicine R Nan Jiang verfasserin aut Linjin Fan verfasserin aut Li Gao verfasserin aut Kai Li verfasserin aut Yulong Gao verfasserin aut Xinxin Niu verfasserin aut Wenying Zhang verfasserin aut Hongyu Cui verfasserin aut Aijing Liu verfasserin aut Qing Pan verfasserin aut Changjun Liu verfasserin aut Yanping Zhang verfasserin aut Xiaomei Wang verfasserin aut Xiaole Qi verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 2, p 142 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:2, p 142 https://doi.org/10.3390/vaccines9020142 kostenfrei https://doaj.org/article/d76e4f928b05400e8f899eb2b62f4de8 kostenfrei https://www.mdpi.com/2076-393X/9/2/142 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 2, p 142 |
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In Vaccines 9(2021), 2, p 142 volume:9 year:2021 number:2, p 142 |
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In Vaccines 9(2021), 2, p 142 volume:9 year:2021 number:2, p 142 |
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Yulong Wang @@aut@@ Nan Jiang @@aut@@ Linjin Fan @@aut@@ Li Gao @@aut@@ Kai Li @@aut@@ Yulong Gao @@aut@@ Xinxin Niu @@aut@@ Wenying Zhang @@aut@@ Hongyu Cui @@aut@@ Aijing Liu @@aut@@ Qing Pan @@aut@@ Changjun Liu @@aut@@ Yanping Zhang @@aut@@ Xiaomei Wang @@aut@@ Xiaole Qi @@aut@@ |
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2021-01-01T00:00:00Z |
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Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus |
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Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. |
abstractGer |
Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. |
abstract_unstemmed |
Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic. |
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Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an <i<Escherichia coli</i< expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. 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