A trans-dimensional approach to the behavioral aspects of depression

Depression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood (assessed with the forced-swimming [FST] a...
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Gespeichert in:

Autor*in:	João M Bessa [verfasserIn] Ana R Mesquita [verfasserIn] Mário Oliveira [verfasserIn] José M Pêgo [verfasserIn] João J Cerqueira [verfasserIn] Joana A Palha [verfasserIn] Osborne F Almeida [verfasserIn] Nuno Sousa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Anxiety Cognition Depression stress modelling Antidepressants

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 3(2009)
Übergeordnetes Werk:	volume:3 ; year:2009

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/neuro.08.001.2009

Katalog-ID:	DOAJ03143147X

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authorswithroles_txt_mv	João M Bessa @@aut@@ Ana R Mesquita @@aut@@ Mário Oliveira @@aut@@ José M Pêgo @@aut@@ João J Cerqueira @@aut@@ Joana A Palha @@aut@@ Osborne F Almeida @@aut@@ Nuno Sousa @@aut@@
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callnumber-first	R - Medicine
author	João M Bessa
spellingShingle	João M Bessa misc RC321-571 misc Anxiety misc Cognition misc Depression misc stress misc modelling misc Antidepressants misc Neurosciences. Biological psychiatry. Neuropsychiatry A trans-dimensional approach to the behavioral aspects of depression
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topic_title	RC321-571 A trans-dimensional approach to the behavioral aspects of depression Anxiety Cognition Depression stress modelling Antidepressants
topic	misc RC321-571 misc Anxiety misc Cognition misc Depression misc stress misc modelling misc Antidepressants misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Anxiety misc Cognition misc Depression misc stress misc modelling misc Antidepressants misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	A trans-dimensional approach to the behavioral aspects of depression
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title_full	A trans-dimensional approach to the behavioral aspects of depression
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title_sort	trans-dimensional approach to the behavioral aspects of depression
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title_auth	A trans-dimensional approach to the behavioral aspects of depression
abstract	Depression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood (assessed with the forced-swimming [FST] and sucrose consumption tests [SCT]), anxiety (elevated-plus maze [EPM] and novelty suppressed feeding [NSF] tests) and cognition (spatial memory and behavioral flexibility tests) in rats exposed to unpredictable chronic-mild-stress (uCMS). Expectedly, uCMS induced depressive-like behavior, a hyperanxious phenotype and cognitive impairment; with the exception of the measure of anxiety in the EPM, these effects were attenuated by antidepressants (imipramine, fluoxetine). Measures of mood by the FST and SCT were strongly correlated, whereas no significant correlations were found between the different measures of anxiety (EPM and NSF); likewise, measures of cognition by spatial memory and behavioral flexibility tests were poorly correlated. Inter-domain analysis revealed significant correlations between mood (FST and SCT) and anxiety-like behavior (NSF, but not EPM). Furthermore, significant correlations were found between cognitive performance (reverse learning task) and mood (FST and SCT) and anxiety-like behavior (NSF). These results demonstrate interactions between different behavioral domains that crosscut the disciplines of psychiatry and neurology.
abstractGer	Depression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood (assessed with the forced-swimming [FST] and sucrose consumption tests [SCT]), anxiety (elevated-plus maze [EPM] and novelty suppressed feeding [NSF] tests) and cognition (spatial memory and behavioral flexibility tests) in rats exposed to unpredictable chronic-mild-stress (uCMS). Expectedly, uCMS induced depressive-like behavior, a hyperanxious phenotype and cognitive impairment; with the exception of the measure of anxiety in the EPM, these effects were attenuated by antidepressants (imipramine, fluoxetine). Measures of mood by the FST and SCT were strongly correlated, whereas no significant correlations were found between the different measures of anxiety (EPM and NSF); likewise, measures of cognition by spatial memory and behavioral flexibility tests were poorly correlated. Inter-domain analysis revealed significant correlations between mood (FST and SCT) and anxiety-like behavior (NSF, but not EPM). Furthermore, significant correlations were found between cognitive performance (reverse learning task) and mood (FST and SCT) and anxiety-like behavior (NSF). These results demonstrate interactions between different behavioral domains that crosscut the disciplines of psychiatry and neurology.
abstract_unstemmed	Depression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood (assessed with the forced-swimming [FST] and sucrose consumption tests [SCT]), anxiety (elevated-plus maze [EPM] and novelty suppressed feeding [NSF] tests) and cognition (spatial memory and behavioral flexibility tests) in rats exposed to unpredictable chronic-mild-stress (uCMS). Expectedly, uCMS induced depressive-like behavior, a hyperanxious phenotype and cognitive impairment; with the exception of the measure of anxiety in the EPM, these effects were attenuated by antidepressants (imipramine, fluoxetine). Measures of mood by the FST and SCT were strongly correlated, whereas no significant correlations were found between the different measures of anxiety (EPM and NSF); likewise, measures of cognition by spatial memory and behavioral flexibility tests were poorly correlated. Inter-domain analysis revealed significant correlations between mood (FST and SCT) and anxiety-like behavior (NSF, but not EPM). Furthermore, significant correlations were found between cognitive performance (reverse learning task) and mood (FST and SCT) and anxiety-like behavior (NSF). These results demonstrate interactions between different behavioral domains that crosscut the disciplines of psychiatry and neurology.
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title_short	A trans-dimensional approach to the behavioral aspects of depression
url	https://doi.org/10.3389/neuro.08.001.2009 https://doaj.org/article/527668d8cfa74d2789269e332e7f1778 http://journal.frontiersin.org/Journal/10.3389/neuro.08.001.2009/full https://doaj.org/toc/1662-5153
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up_date	2024-07-03T20:33:47.164Z
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A trans-dimensional approach to the behavioral aspects of depression

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