Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya

Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected p...
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Autor*in:	Anne Njoroge [verfasserIn] B. L. Guthrie [verfasserIn] Rose Bosire [verfasserIn] Mark Wener [verfasserIn] James Kiarie [verfasserIn] Carey Farquhar [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Dyslipidemia Cholesterol HIV Kenya HDL

Übergeordnetes Werk:	In: Lipids in Health and Disease - BMC, 2003, 16(2017), 1, Seite 7
Übergeordnetes Werk:	volume:16 ; year:2017 ; number:1 ; pages:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12944-017-0503-9

Katalog-ID:	DOAJ031519326

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520			\|a Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression.
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allfields	10.1186/s12944-017-0503-9 doi (DE-627)DOAJ031519326 (DE-599)DOAJa04a3d9aa4e4413281b768ce9f18c0cb DE-627 ger DE-627 rakwb eng RC620-627 Anne Njoroge verfasserin aut Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression. Dyslipidemia Cholesterol HIV Kenya HDL Nutritional diseases. Deficiency diseases B. L. Guthrie verfasserin aut Rose Bosire verfasserin aut Mark Wener verfasserin aut James Kiarie verfasserin aut Carey Farquhar verfasserin aut In Lipids in Health and Disease BMC, 2003 16(2017), 1, Seite 7 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:16 year:2017 number:1 pages:7 https://doi.org/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/article/a04a3d9aa4e4413281b768ce9f18c0cb kostenfrei http://link.springer.com/article/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 7
spelling	10.1186/s12944-017-0503-9 doi (DE-627)DOAJ031519326 (DE-599)DOAJa04a3d9aa4e4413281b768ce9f18c0cb DE-627 ger DE-627 rakwb eng RC620-627 Anne Njoroge verfasserin aut Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression. Dyslipidemia Cholesterol HIV Kenya HDL Nutritional diseases. Deficiency diseases B. L. Guthrie verfasserin aut Rose Bosire verfasserin aut Mark Wener verfasserin aut James Kiarie verfasserin aut Carey Farquhar verfasserin aut In Lipids in Health and Disease BMC, 2003 16(2017), 1, Seite 7 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:16 year:2017 number:1 pages:7 https://doi.org/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/article/a04a3d9aa4e4413281b768ce9f18c0cb kostenfrei http://link.springer.com/article/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 7
allfields_unstemmed	10.1186/s12944-017-0503-9 doi (DE-627)DOAJ031519326 (DE-599)DOAJa04a3d9aa4e4413281b768ce9f18c0cb DE-627 ger DE-627 rakwb eng RC620-627 Anne Njoroge verfasserin aut Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression. Dyslipidemia Cholesterol HIV Kenya HDL Nutritional diseases. Deficiency diseases B. L. Guthrie verfasserin aut Rose Bosire verfasserin aut Mark Wener verfasserin aut James Kiarie verfasserin aut Carey Farquhar verfasserin aut In Lipids in Health and Disease BMC, 2003 16(2017), 1, Seite 7 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:16 year:2017 number:1 pages:7 https://doi.org/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/article/a04a3d9aa4e4413281b768ce9f18c0cb kostenfrei http://link.springer.com/article/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 7
allfieldsGer	10.1186/s12944-017-0503-9 doi (DE-627)DOAJ031519326 (DE-599)DOAJa04a3d9aa4e4413281b768ce9f18c0cb DE-627 ger DE-627 rakwb eng RC620-627 Anne Njoroge verfasserin aut Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression. Dyslipidemia Cholesterol HIV Kenya HDL Nutritional diseases. Deficiency diseases B. L. Guthrie verfasserin aut Rose Bosire verfasserin aut Mark Wener verfasserin aut James Kiarie verfasserin aut Carey Farquhar verfasserin aut In Lipids in Health and Disease BMC, 2003 16(2017), 1, Seite 7 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:16 year:2017 number:1 pages:7 https://doi.org/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/article/a04a3d9aa4e4413281b768ce9f18c0cb kostenfrei http://link.springer.com/article/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 7
allfieldsSound	10.1186/s12944-017-0503-9 doi (DE-627)DOAJ031519326 (DE-599)DOAJa04a3d9aa4e4413281b768ce9f18c0cb DE-627 ger DE-627 rakwb eng RC620-627 Anne Njoroge verfasserin aut Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression. Dyslipidemia Cholesterol HIV Kenya HDL Nutritional diseases. Deficiency diseases B. L. Guthrie verfasserin aut Rose Bosire verfasserin aut Mark Wener verfasserin aut James Kiarie verfasserin aut Carey Farquhar verfasserin aut In Lipids in Health and Disease BMC, 2003 16(2017), 1, Seite 7 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:16 year:2017 number:1 pages:7 https://doi.org/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/article/a04a3d9aa4e4413281b768ce9f18c0cb kostenfrei http://link.springer.com/article/10.1186/s12944-017-0503-9 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 7
language	English
source	In Lipids in Health and Disease 16(2017), 1, Seite 7 volume:16 year:2017 number:1 pages:7
sourceStr	In Lipids in Health and Disease 16(2017), 1, Seite 7 volume:16 year:2017 number:1 pages:7
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Dyslipidemia Cholesterol HIV Kenya HDL Nutritional diseases. Deficiency diseases
isfreeaccess_bool	true
container_title	Lipids in Health and Disease
authorswithroles_txt_mv	Anne Njoroge @@aut@@ B. L. Guthrie @@aut@@ Rose Bosire @@aut@@ Mark Wener @@aut@@ James Kiarie @@aut@@ Carey Farquhar @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	355987694
id	DOAJ031519326
language_de	englisch
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We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. 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callnumber-first	R - Medicine
author	Anne Njoroge
spellingShingle	Anne Njoroge misc RC620-627 misc Dyslipidemia misc Cholesterol misc HIV misc Kenya misc HDL misc Nutritional diseases. Deficiency diseases Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya
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topic_title	RC620-627 Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya Dyslipidemia Cholesterol HIV Kenya HDL
topic	misc RC620-627 misc Dyslipidemia misc Cholesterol misc HIV misc Kenya misc HDL misc Nutritional diseases. Deficiency diseases
topic_unstemmed	misc RC620-627 misc Dyslipidemia misc Cholesterol misc HIV misc Kenya misc HDL misc Nutritional diseases. Deficiency diseases
topic_browse	misc RC620-627 misc Dyslipidemia misc Cholesterol misc HIV misc Kenya misc HDL misc Nutritional diseases. Deficiency diseases
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title	Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya
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title_full	Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya
author_sort	Anne Njoroge
journal	Lipids in Health and Disease
journalStr	Lipids in Health and Disease
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author_browse	Anne Njoroge B. L. Guthrie Rose Bosire Mark Wener James Kiarie Carey Farquhar
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author-letter	Anne Njoroge
doi_str_mv	10.1186/s12944-017-0503-9
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title_sort	low hdl-cholesterol among hiv-1 infected and hiv-1 uninfected individuals in nairobi, kenya
callnumber	RC620-627
title_auth	Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya
abstract	Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression.
abstractGer	Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression.
abstract_unstemmed	Abstract Background Antiretroviral treatment (ART) is associated with dyslipidemia yet little is known about the burden of dyslipidemia in the absence of ART in sub-Saharan Africa. We compared the prevalence and risk factors for dyslipidemia among HIV-infected ART-naïve adults and their uninfected partners in Nairobi, Kenya. Methods Non-fasting total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels were measured by standard lipid spectrophotometry on thawed plasma samples obtained from HIV-infected participants and their uninfected partners. Dyslipidemia, defined by high TC (<200 mg/dl) or low HDL (<40 mg/dl) was compared between HIV-infected and uninfected men and women. Results Among 196 participants, median age was 32 years [IQR: 23–41]. Median CD4 count among the HIV-infected was 393 cells/ μl (IQR: 57–729) and 90% had a viral load <1000 copies/ml. Mean TC and HDL were comparable for HIV-infected and uninfected participants. Prevalence of dyslipidemia was 83.8% vs 78.4% (p = 0.27). Among the HIV-infected, those with a viral load <1000 copies/ml were 1.5-fold more likely to have dyslipidemia compared to those with ≤1000 copies/ml (adjusted prevalence ratio [aPR] 1.5, 95% CI: 1.22–30.99, p = 0.02). BMI, age, gender, blood pressure and smoking were not significantly associated with dyslipidemia. Conclusions Among ART-naïve HIV-infected adults, high viral load and low CD4 cell count were independent predictors of dyslipidemia, underscoring the importance of early initiation of ART for viral suppression.
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title_short	Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya
url	https://doi.org/10.1186/s12944-017-0503-9 https://doaj.org/article/a04a3d9aa4e4413281b768ce9f18c0cb http://link.springer.com/article/10.1186/s12944-017-0503-9 https://doaj.org/toc/1476-511X
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Low HDL-cholesterol among HIV-1 infected and HIV-1 uninfected individuals in Nairobi, Kenya

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