Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells
Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be...
Ausführliche Beschreibung
Autor*in: |
Chung-Chih Tseng [verfasserIn] Yu-Cheng Lai [verfasserIn] Tsu-Jen Kuo [verfasserIn] Jui-Hsin Su [verfasserIn] Ping-Jyun Sung [verfasserIn] Chien-Wei Feng [verfasserIn] Yen-You Lin [verfasserIn] Pei-Chin Chen [verfasserIn] Ming-Hong Tai [verfasserIn] Shu-Yu Cheng [verfasserIn] Hsiao-Mei Kuo [verfasserIn] Zhi-Hong Wen [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Marine Drugs - MDPI AG, 2005, 17(2019), 3, p 138 |
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Übergeordnetes Werk: |
volume:17 ; year:2019 ; number:3, p 138 |
Links: |
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DOI / URN: |
10.3390/md17030138 |
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Katalog-ID: |
DOAJ03162328X |
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10.3390/md17030138 doi (DE-627)DOAJ03162328X (DE-599)DOAJb534ab07e29d4ecdb648e285d5ee4f8c DE-627 ger DE-627 rakwb eng QH301-705.5 Chung-Chih Tseng verfasserin aut Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR. gingival recession oral mucosa fibroblasts extracellular matrix mitochondria oxidative phosphorylation Biology (General) Yu-Cheng Lai verfasserin aut Tsu-Jen Kuo verfasserin aut Jui-Hsin Su verfasserin aut Ping-Jyun Sung verfasserin aut Chien-Wei Feng verfasserin aut Yen-You Lin verfasserin aut Pei-Chin Chen verfasserin aut Ming-Hong Tai verfasserin aut Shu-Yu Cheng verfasserin aut Hsiao-Mei Kuo verfasserin aut Zhi-Hong Wen verfasserin aut In Marine Drugs MDPI AG, 2005 17(2019), 3, p 138 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:17 year:2019 number:3, p 138 https://doi.org/10.3390/md17030138 kostenfrei https://doaj.org/article/b534ab07e29d4ecdb648e285d5ee4f8c kostenfrei https://www.mdpi.com/1660-3397/17/3/138 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 3, p 138 |
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10.3390/md17030138 doi (DE-627)DOAJ03162328X (DE-599)DOAJb534ab07e29d4ecdb648e285d5ee4f8c DE-627 ger DE-627 rakwb eng QH301-705.5 Chung-Chih Tseng verfasserin aut Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR. gingival recession oral mucosa fibroblasts extracellular matrix mitochondria oxidative phosphorylation Biology (General) Yu-Cheng Lai verfasserin aut Tsu-Jen Kuo verfasserin aut Jui-Hsin Su verfasserin aut Ping-Jyun Sung verfasserin aut Chien-Wei Feng verfasserin aut Yen-You Lin verfasserin aut Pei-Chin Chen verfasserin aut Ming-Hong Tai verfasserin aut Shu-Yu Cheng verfasserin aut Hsiao-Mei Kuo verfasserin aut Zhi-Hong Wen verfasserin aut In Marine Drugs MDPI AG, 2005 17(2019), 3, p 138 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:17 year:2019 number:3, p 138 https://doi.org/10.3390/md17030138 kostenfrei https://doaj.org/article/b534ab07e29d4ecdb648e285d5ee4f8c kostenfrei https://www.mdpi.com/1660-3397/17/3/138 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 3, p 138 |
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10.3390/md17030138 doi (DE-627)DOAJ03162328X (DE-599)DOAJb534ab07e29d4ecdb648e285d5ee4f8c DE-627 ger DE-627 rakwb eng QH301-705.5 Chung-Chih Tseng verfasserin aut Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR. gingival recession oral mucosa fibroblasts extracellular matrix mitochondria oxidative phosphorylation Biology (General) Yu-Cheng Lai verfasserin aut Tsu-Jen Kuo verfasserin aut Jui-Hsin Su verfasserin aut Ping-Jyun Sung verfasserin aut Chien-Wei Feng verfasserin aut Yen-You Lin verfasserin aut Pei-Chin Chen verfasserin aut Ming-Hong Tai verfasserin aut Shu-Yu Cheng verfasserin aut Hsiao-Mei Kuo verfasserin aut Zhi-Hong Wen verfasserin aut In Marine Drugs MDPI AG, 2005 17(2019), 3, p 138 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:17 year:2019 number:3, p 138 https://doi.org/10.3390/md17030138 kostenfrei https://doaj.org/article/b534ab07e29d4ecdb648e285d5ee4f8c kostenfrei https://www.mdpi.com/1660-3397/17/3/138 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 3, p 138 |
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10.3390/md17030138 doi (DE-627)DOAJ03162328X (DE-599)DOAJb534ab07e29d4ecdb648e285d5ee4f8c DE-627 ger DE-627 rakwb eng QH301-705.5 Chung-Chih Tseng verfasserin aut Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR. gingival recession oral mucosa fibroblasts extracellular matrix mitochondria oxidative phosphorylation Biology (General) Yu-Cheng Lai verfasserin aut Tsu-Jen Kuo verfasserin aut Jui-Hsin Su verfasserin aut Ping-Jyun Sung verfasserin aut Chien-Wei Feng verfasserin aut Yen-You Lin verfasserin aut Pei-Chin Chen verfasserin aut Ming-Hong Tai verfasserin aut Shu-Yu Cheng verfasserin aut Hsiao-Mei Kuo verfasserin aut Zhi-Hong Wen verfasserin aut In Marine Drugs MDPI AG, 2005 17(2019), 3, p 138 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:17 year:2019 number:3, p 138 https://doi.org/10.3390/md17030138 kostenfrei https://doaj.org/article/b534ab07e29d4ecdb648e285d5ee4f8c kostenfrei https://www.mdpi.com/1660-3397/17/3/138 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 3, p 138 |
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Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells |
abstract |
Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR. |
abstractGer |
Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR. |
abstract_unstemmed |
Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR. |
collection_details |
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container_issue |
3, p 138 |
title_short |
Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells |
url |
https://doi.org/10.3390/md17030138 https://doaj.org/article/b534ab07e29d4ecdb648e285d5ee4f8c https://www.mdpi.com/1660-3397/17/3/138 https://doaj.org/toc/1660-3397 |
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author2 |
Yu-Cheng Lai Tsu-Jen Kuo Jui-Hsin Su Ping-Jyun Sung Chien-Wei Feng Yen-You Lin Pei-Chin Chen Ming-Hong Tai Shu-Yu Cheng Hsiao-Mei Kuo Zhi-Hong Wen |
author2Str |
Yu-Cheng Lai Tsu-Jen Kuo Jui-Hsin Su Ping-Jyun Sung Chien-Wei Feng Yen-You Lin Pei-Chin Chen Ming-Hong Tai Shu-Yu Cheng Hsiao-Mei Kuo Zhi-Hong Wen |
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doi_str |
10.3390/md17030138 |
callnumber-a |
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up_date |
2024-07-03T21:36:15.547Z |
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