Immune profile in aborted Iraqi women with toxoplasmosis

Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Met...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Muhammed Abdul-Gabar Hamoodi Aldabagh [verfasserIn] Sadeq Kadhin Hachim [verfasserIn] Khalid Waleed Qassim [verfasserIn] Qasim Sharhan Al-Mayah [verfasserIn] Jabbar Salman Hassan [verfasserIn] Dunya Fareed Salloom [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis

Übergeordnetes Werk:	In: Medical Journal of Babylon - Wolters Kluwer Medknow Publications, 2019, 15(2018), 1, Seite 48-52
Übergeordnetes Werk:	volume:15 ; year:2018 ; number:1 ; pages:48-52

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/MJBL.MJBL_13_18

Katalog-ID:	DOAJ031682375

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520			\|a Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication.
650		4	\|a Abortion
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Indexfelder

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allfields	10.4103/MJBL.MJBL_13_18 doi (DE-627)DOAJ031682375 (DE-599)DOAJd6b6615d16ff47dcb931a45c4889ffff DE-627 ger DE-627 rakwb eng Muhammed Abdul-Gabar Hamoodi Aldabagh verfasserin aut Immune profile in aborted Iraqi women with toxoplasmosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication. Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis Medicine R Sadeq Kadhin Hachim verfasserin aut Khalid Waleed Qassim verfasserin aut Qasim Sharhan Al-Mayah verfasserin aut Jabbar Salman Hassan verfasserin aut Dunya Fareed Salloom verfasserin aut In Medical Journal of Babylon Wolters Kluwer Medknow Publications, 2019 15(2018), 1, Seite 48-52 (DE-627)770032974 (DE-600)2737269-8 23126760 nnns volume:15 year:2018 number:1 pages:48-52 https://doi.org/10.4103/MJBL.MJBL_13_18 kostenfrei https://doaj.org/article/d6b6615d16ff47dcb931a45c4889ffff kostenfrei http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2018;volume=15;issue=1;spage=48;epage=52;aulast=Aldabagh kostenfrei https://doaj.org/toc/1812-156X Journal toc kostenfrei https://doaj.org/toc/2312-6760 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2018 1 48-52
spelling	10.4103/MJBL.MJBL_13_18 doi (DE-627)DOAJ031682375 (DE-599)DOAJd6b6615d16ff47dcb931a45c4889ffff DE-627 ger DE-627 rakwb eng Muhammed Abdul-Gabar Hamoodi Aldabagh verfasserin aut Immune profile in aborted Iraqi women with toxoplasmosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication. Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis Medicine R Sadeq Kadhin Hachim verfasserin aut Khalid Waleed Qassim verfasserin aut Qasim Sharhan Al-Mayah verfasserin aut Jabbar Salman Hassan verfasserin aut Dunya Fareed Salloom verfasserin aut In Medical Journal of Babylon Wolters Kluwer Medknow Publications, 2019 15(2018), 1, Seite 48-52 (DE-627)770032974 (DE-600)2737269-8 23126760 nnns volume:15 year:2018 number:1 pages:48-52 https://doi.org/10.4103/MJBL.MJBL_13_18 kostenfrei https://doaj.org/article/d6b6615d16ff47dcb931a45c4889ffff kostenfrei http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2018;volume=15;issue=1;spage=48;epage=52;aulast=Aldabagh kostenfrei https://doaj.org/toc/1812-156X Journal toc kostenfrei https://doaj.org/toc/2312-6760 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2018 1 48-52
allfields_unstemmed	10.4103/MJBL.MJBL_13_18 doi (DE-627)DOAJ031682375 (DE-599)DOAJd6b6615d16ff47dcb931a45c4889ffff DE-627 ger DE-627 rakwb eng Muhammed Abdul-Gabar Hamoodi Aldabagh verfasserin aut Immune profile in aborted Iraqi women with toxoplasmosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication. Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis Medicine R Sadeq Kadhin Hachim verfasserin aut Khalid Waleed Qassim verfasserin aut Qasim Sharhan Al-Mayah verfasserin aut Jabbar Salman Hassan verfasserin aut Dunya Fareed Salloom verfasserin aut In Medical Journal of Babylon Wolters Kluwer Medknow Publications, 2019 15(2018), 1, Seite 48-52 (DE-627)770032974 (DE-600)2737269-8 23126760 nnns volume:15 year:2018 number:1 pages:48-52 https://doi.org/10.4103/MJBL.MJBL_13_18 kostenfrei https://doaj.org/article/d6b6615d16ff47dcb931a45c4889ffff kostenfrei http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2018;volume=15;issue=1;spage=48;epage=52;aulast=Aldabagh kostenfrei https://doaj.org/toc/1812-156X Journal toc kostenfrei https://doaj.org/toc/2312-6760 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2018 1 48-52
allfieldsGer	10.4103/MJBL.MJBL_13_18 doi (DE-627)DOAJ031682375 (DE-599)DOAJd6b6615d16ff47dcb931a45c4889ffff DE-627 ger DE-627 rakwb eng Muhammed Abdul-Gabar Hamoodi Aldabagh verfasserin aut Immune profile in aborted Iraqi women with toxoplasmosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication. Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis Medicine R Sadeq Kadhin Hachim verfasserin aut Khalid Waleed Qassim verfasserin aut Qasim Sharhan Al-Mayah verfasserin aut Jabbar Salman Hassan verfasserin aut Dunya Fareed Salloom verfasserin aut In Medical Journal of Babylon Wolters Kluwer Medknow Publications, 2019 15(2018), 1, Seite 48-52 (DE-627)770032974 (DE-600)2737269-8 23126760 nnns volume:15 year:2018 number:1 pages:48-52 https://doi.org/10.4103/MJBL.MJBL_13_18 kostenfrei https://doaj.org/article/d6b6615d16ff47dcb931a45c4889ffff kostenfrei http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2018;volume=15;issue=1;spage=48;epage=52;aulast=Aldabagh kostenfrei https://doaj.org/toc/1812-156X Journal toc kostenfrei https://doaj.org/toc/2312-6760 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2018 1 48-52
allfieldsSound	10.4103/MJBL.MJBL_13_18 doi (DE-627)DOAJ031682375 (DE-599)DOAJd6b6615d16ff47dcb931a45c4889ffff DE-627 ger DE-627 rakwb eng Muhammed Abdul-Gabar Hamoodi Aldabagh verfasserin aut Immune profile in aborted Iraqi women with toxoplasmosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication. Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis Medicine R Sadeq Kadhin Hachim verfasserin aut Khalid Waleed Qassim verfasserin aut Qasim Sharhan Al-Mayah verfasserin aut Jabbar Salman Hassan verfasserin aut Dunya Fareed Salloom verfasserin aut In Medical Journal of Babylon Wolters Kluwer Medknow Publications, 2019 15(2018), 1, Seite 48-52 (DE-627)770032974 (DE-600)2737269-8 23126760 nnns volume:15 year:2018 number:1 pages:48-52 https://doi.org/10.4103/MJBL.MJBL_13_18 kostenfrei https://doaj.org/article/d6b6615d16ff47dcb931a45c4889ffff kostenfrei http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2018;volume=15;issue=1;spage=48;epage=52;aulast=Aldabagh kostenfrei https://doaj.org/toc/1812-156X Journal toc kostenfrei https://doaj.org/toc/2312-6760 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2018 1 48-52
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source	In Medical Journal of Babylon 15(2018), 1, Seite 48-52 volume:15 year:2018 number:1 pages:48-52
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topic_facet	Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis Medicine R
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authorswithroles_txt_mv	Muhammed Abdul-Gabar Hamoodi Aldabagh @@aut@@ Sadeq Kadhin Hachim @@aut@@ Khalid Waleed Qassim @@aut@@ Qasim Sharhan Al-Mayah @@aut@@ Jabbar Salman Hassan @@aut@@ Dunya Fareed Salloom @@aut@@
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author	Muhammed Abdul-Gabar Hamoodi Aldabagh
spellingShingle	Muhammed Abdul-Gabar Hamoodi Aldabagh misc Abortion misc adaptive immune response misc innate immune response misc single radial immune diffusion misc toxoplasmosis misc Medicine misc R Immune profile in aborted Iraqi women with toxoplasmosis
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topic_title	Immune profile in aborted Iraqi women with toxoplasmosis Abortion adaptive immune response innate immune response single radial immune diffusion toxoplasmosis
topic	misc Abortion misc adaptive immune response misc innate immune response misc single radial immune diffusion misc toxoplasmosis misc Medicine misc R
topic_unstemmed	misc Abortion misc adaptive immune response misc innate immune response misc single radial immune diffusion misc toxoplasmosis misc Medicine misc R
topic_browse	misc Abortion misc adaptive immune response misc innate immune response misc single radial immune diffusion misc toxoplasmosis misc Medicine misc R
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title	Immune profile in aborted Iraqi women with toxoplasmosis
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title_full	Immune profile in aborted Iraqi women with toxoplasmosis
author_sort	Muhammed Abdul-Gabar Hamoodi Aldabagh
journal	Medical Journal of Babylon
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author_browse	Muhammed Abdul-Gabar Hamoodi Aldabagh Sadeq Kadhin Hachim Khalid Waleed Qassim Qasim Sharhan Al-Mayah Jabbar Salman Hassan Dunya Fareed Salloom
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author-letter	Muhammed Abdul-Gabar Hamoodi Aldabagh
doi_str_mv	10.4103/MJBL.MJBL_13_18
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title_sort	immune profile in aborted iraqi women with toxoplasmosis
title_auth	Immune profile in aborted Iraqi women with toxoplasmosis
abstract	Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication.
abstractGer	Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication.
abstract_unstemmed	Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Immune profile in aborted Iraqi women with toxoplasmosis
url	https://doi.org/10.4103/MJBL.MJBL_13_18 https://doaj.org/article/d6b6615d16ff47dcb931a45c4889ffff http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2018;volume=15;issue=1;spage=48;epage=52;aulast=Aldabagh https://doaj.org/toc/1812-156X https://doaj.org/toc/2312-6760
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author2	Sadeq Kadhin Hachim Khalid Waleed Qassim Qasim Sharhan Al-Mayah Jabbar Salman Hassan Dunya Fareed Salloom
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doi_str	10.4103/MJBL.MJBL_13_18
up_date	2024-07-03T21:55:16.821Z
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