Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patie...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kevin Baßler [verfasserIn] Wataru Fujii [verfasserIn] Theodore S. Kapellos [verfasserIn] Erika Dudkin [verfasserIn] Nico Reusch [verfasserIn] Ari Horne [verfasserIn] Benedikt Reiz [verfasserIn] Malte D. Luecken [verfasserIn] Collins Osei-Sarpong [verfasserIn] Stefanie Warnat-Herresthal [verfasserIn] Lorenzo Bonaguro [verfasserIn] Jonas Schulte-Schrepping [verfasserIn] Allon Wagner [verfasserIn] Patrick Günther [verfasserIn] Carmen Pizarro [verfasserIn] Tina Schreiber [verfasserIn] Rainer Knoll [verfasserIn] Lisa Holsten [verfasserIn] Charlotte Kröger [verfasserIn] Elena De Domenico [verfasserIn] Matthias Becker [verfasserIn] Kristian Händler [verfasserIn] Christian T. Wohnhaas [verfasserIn] Florian Baumgartner [verfasserIn] Meike Köhler [verfasserIn] Heidi Theis [verfasserIn] Michael Kraut [verfasserIn] Marc H. Wadsworth [verfasserIn] Travis K. Hughes [verfasserIn] Humberto J. Ferreira [verfasserIn] Emily Hinkley [verfasserIn] Ines H. Kaltheuner [verfasserIn] Matthias Geyer [verfasserIn] Christoph Thiele [verfasserIn] Alex K. Shalek [verfasserIn] Andreas Feißt [verfasserIn] Daniel Thomas [verfasserIn] Henning Dickten [verfasserIn] Marc Beyer [verfasserIn] Patrick Baum [verfasserIn] Nir Yosef [verfasserIn] Anna C. Aschenbrenner [verfasserIn] Thomas Ulas [verfasserIn] Jan Hasenauer [verfasserIn] Fabian J. Theis [verfasserIn] Dirk Skowasch [verfasserIn] Joachim L. Schultze [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022) |
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| Übergeordnetes Werk: |
volume:13 ; year:2022 |
| Links: |
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| DOI / URN: |
10.3389/fimmu.2022.917232 |
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| Katalog-ID: |
DOAJ031787614 |
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| 520 | |a Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation. | ||
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10.3389/fimmu.2022.917232 doi (DE-627)DOAJ031787614 (DE-599)DOAJe0f1f3d9372546f1a11d2fa5f19b33eb DE-627 ger DE-627 rakwb eng RC581-607 Kevin Baßler verfasserin aut Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation. chronic obstructive pulmonary disease bronchoalveolar lavage blood macrophage monocyte impaired immune activation Immunologic diseases. Allergy Wataru Fujii verfasserin aut Theodore S. Kapellos verfasserin aut Erika Dudkin verfasserin aut Nico Reusch verfasserin aut Ari Horne verfasserin aut Benedikt Reiz verfasserin aut Malte D. Luecken verfasserin aut Collins Osei-Sarpong verfasserin aut Stefanie Warnat-Herresthal verfasserin aut Lorenzo Bonaguro verfasserin aut Lorenzo Bonaguro verfasserin aut Lorenzo Bonaguro verfasserin aut Jonas Schulte-Schrepping verfasserin aut Allon Wagner verfasserin aut Allon Wagner verfasserin aut Patrick Günther verfasserin aut Carmen Pizarro verfasserin aut Tina Schreiber verfasserin aut Rainer Knoll verfasserin aut Rainer Knoll verfasserin aut Rainer Knoll verfasserin aut Lisa Holsten verfasserin aut Charlotte Kröger verfasserin aut Charlotte Kröger verfasserin aut Elena De Domenico verfasserin aut Elena De Domenico verfasserin aut Matthias Becker verfasserin aut Matthias Becker verfasserin aut Kristian Händler verfasserin aut Kristian Händler verfasserin aut Christian T. Wohnhaas verfasserin aut Florian Baumgartner verfasserin aut Meike Köhler verfasserin aut Heidi Theis verfasserin aut Heidi Theis verfasserin aut Michael Kraut verfasserin aut Michael Kraut verfasserin aut Marc H. Wadsworth verfasserin aut Marc H. Wadsworth verfasserin aut Travis K. Hughes verfasserin aut Humberto J. Ferreira verfasserin aut Emily Hinkley verfasserin aut Emily Hinkley verfasserin aut Ines H. Kaltheuner verfasserin aut Matthias Geyer verfasserin aut Christoph Thiele verfasserin aut Alex K. Shalek verfasserin aut Alex K. Shalek verfasserin aut Andreas Feißt verfasserin aut Daniel Thomas verfasserin aut Henning Dickten verfasserin aut Marc Beyer verfasserin aut Marc Beyer verfasserin aut Marc Beyer verfasserin aut Patrick Baum verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Anna C. Aschenbrenner verfasserin aut Anna C. Aschenbrenner verfasserin aut Anna C. Aschenbrenner verfasserin aut Thomas Ulas verfasserin aut Thomas Ulas verfasserin aut Thomas Ulas verfasserin aut Jan Hasenauer verfasserin aut Jan Hasenauer verfasserin aut Fabian J. Theis verfasserin aut Fabian J. Theis verfasserin aut Dirk Skowasch verfasserin aut Joachim L. Schultze verfasserin aut Joachim L. Schultze verfasserin aut Joachim L. Schultze verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.917232 kostenfrei https://doaj.org/article/e0f1f3d9372546f1a11d2fa5f19b33eb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.917232/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.917232 doi (DE-627)DOAJ031787614 (DE-599)DOAJe0f1f3d9372546f1a11d2fa5f19b33eb DE-627 ger DE-627 rakwb eng RC581-607 Kevin Baßler verfasserin aut Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation. chronic obstructive pulmonary disease bronchoalveolar lavage blood macrophage monocyte impaired immune activation Immunologic diseases. Allergy Wataru Fujii verfasserin aut Theodore S. Kapellos verfasserin aut Erika Dudkin verfasserin aut Nico Reusch verfasserin aut Ari Horne verfasserin aut Benedikt Reiz verfasserin aut Malte D. Luecken verfasserin aut Collins Osei-Sarpong verfasserin aut Stefanie Warnat-Herresthal verfasserin aut Lorenzo Bonaguro verfasserin aut Lorenzo Bonaguro verfasserin aut Lorenzo Bonaguro verfasserin aut Jonas Schulte-Schrepping verfasserin aut Allon Wagner verfasserin aut Allon Wagner verfasserin aut Patrick Günther verfasserin aut Carmen Pizarro verfasserin aut Tina Schreiber verfasserin aut Rainer Knoll verfasserin aut Rainer Knoll verfasserin aut Rainer Knoll verfasserin aut Lisa Holsten verfasserin aut Charlotte Kröger verfasserin aut Charlotte Kröger verfasserin aut Elena De Domenico verfasserin aut Elena De Domenico verfasserin aut Matthias Becker verfasserin aut Matthias Becker verfasserin aut Kristian Händler verfasserin aut Kristian Händler verfasserin aut Christian T. Wohnhaas verfasserin aut Florian Baumgartner verfasserin aut Meike Köhler verfasserin aut Heidi Theis verfasserin aut Heidi Theis verfasserin aut Michael Kraut verfasserin aut Michael Kraut verfasserin aut Marc H. Wadsworth verfasserin aut Marc H. Wadsworth verfasserin aut Travis K. Hughes verfasserin aut Humberto J. Ferreira verfasserin aut Emily Hinkley verfasserin aut Emily Hinkley verfasserin aut Ines H. Kaltheuner verfasserin aut Matthias Geyer verfasserin aut Christoph Thiele verfasserin aut Alex K. Shalek verfasserin aut Alex K. Shalek verfasserin aut Andreas Feißt verfasserin aut Daniel Thomas verfasserin aut Henning Dickten verfasserin aut Marc Beyer verfasserin aut Marc Beyer verfasserin aut Marc Beyer verfasserin aut Patrick Baum verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Anna C. Aschenbrenner verfasserin aut Anna C. Aschenbrenner verfasserin aut Anna C. Aschenbrenner verfasserin aut Thomas Ulas verfasserin aut Thomas Ulas verfasserin aut Thomas Ulas verfasserin aut Jan Hasenauer verfasserin aut Jan Hasenauer verfasserin aut Fabian J. Theis verfasserin aut Fabian J. Theis verfasserin aut Dirk Skowasch verfasserin aut Joachim L. Schultze verfasserin aut Joachim L. Schultze verfasserin aut Joachim L. Schultze verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.917232 kostenfrei https://doaj.org/article/e0f1f3d9372546f1a11d2fa5f19b33eb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.917232/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.917232 doi (DE-627)DOAJ031787614 (DE-599)DOAJe0f1f3d9372546f1a11d2fa5f19b33eb DE-627 ger DE-627 rakwb eng RC581-607 Kevin Baßler verfasserin aut Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation. chronic obstructive pulmonary disease bronchoalveolar lavage blood macrophage monocyte impaired immune activation Immunologic diseases. Allergy Wataru Fujii verfasserin aut Theodore S. Kapellos verfasserin aut Erika Dudkin verfasserin aut Nico Reusch verfasserin aut Ari Horne verfasserin aut Benedikt Reiz verfasserin aut Malte D. Luecken verfasserin aut Collins Osei-Sarpong verfasserin aut Stefanie Warnat-Herresthal verfasserin aut Lorenzo Bonaguro verfasserin aut Lorenzo Bonaguro verfasserin aut Lorenzo Bonaguro verfasserin aut Jonas Schulte-Schrepping verfasserin aut Allon Wagner verfasserin aut Allon Wagner verfasserin aut Patrick Günther verfasserin aut Carmen Pizarro verfasserin aut Tina Schreiber verfasserin aut Rainer Knoll verfasserin aut Rainer Knoll verfasserin aut Rainer Knoll verfasserin aut Lisa Holsten verfasserin aut Charlotte Kröger verfasserin aut Charlotte Kröger verfasserin aut Elena De Domenico verfasserin aut Elena De Domenico verfasserin aut Matthias Becker verfasserin aut Matthias Becker verfasserin aut Kristian Händler verfasserin aut Kristian Händler verfasserin aut Christian T. Wohnhaas verfasserin aut Florian Baumgartner verfasserin aut Meike Köhler verfasserin aut Heidi Theis verfasserin aut Heidi Theis verfasserin aut Michael Kraut verfasserin aut Michael Kraut verfasserin aut Marc H. Wadsworth verfasserin aut Marc H. Wadsworth verfasserin aut Travis K. Hughes verfasserin aut Humberto J. Ferreira verfasserin aut Emily Hinkley verfasserin aut Emily Hinkley verfasserin aut Ines H. Kaltheuner verfasserin aut Matthias Geyer verfasserin aut Christoph Thiele verfasserin aut Alex K. Shalek verfasserin aut Alex K. Shalek verfasserin aut Andreas Feißt verfasserin aut Daniel Thomas verfasserin aut Henning Dickten verfasserin aut Marc Beyer verfasserin aut Marc Beyer verfasserin aut Marc Beyer verfasserin aut Patrick Baum verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Nir Yosef verfasserin aut Anna C. Aschenbrenner verfasserin aut Anna C. Aschenbrenner verfasserin aut Anna C. Aschenbrenner verfasserin aut Thomas Ulas verfasserin aut Thomas Ulas verfasserin aut Thomas Ulas verfasserin aut Jan Hasenauer verfasserin aut Jan Hasenauer verfasserin aut Fabian J. Theis verfasserin aut Fabian J. Theis verfasserin aut Dirk Skowasch verfasserin aut Joachim L. Schultze verfasserin aut Joachim L. Schultze verfasserin aut Joachim L. Schultze verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.917232 kostenfrei https://doaj.org/article/e0f1f3d9372546f1a11d2fa5f19b33eb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.917232/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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Kevin Baßler @@aut@@ Wataru Fujii @@aut@@ Theodore S. Kapellos @@aut@@ Erika Dudkin @@aut@@ Nico Reusch @@aut@@ Ari Horne @@aut@@ Benedikt Reiz @@aut@@ Malte D. Luecken @@aut@@ Collins Osei-Sarpong @@aut@@ Stefanie Warnat-Herresthal @@aut@@ Lorenzo Bonaguro @@aut@@ Jonas Schulte-Schrepping @@aut@@ Allon Wagner @@aut@@ Patrick Günther @@aut@@ Carmen Pizarro @@aut@@ Tina Schreiber @@aut@@ Rainer Knoll @@aut@@ Lisa Holsten @@aut@@ Charlotte Kröger @@aut@@ Elena De Domenico @@aut@@ Matthias Becker @@aut@@ Kristian Händler @@aut@@ Christian T. Wohnhaas @@aut@@ Florian Baumgartner @@aut@@ Meike Köhler @@aut@@ Heidi Theis @@aut@@ Michael Kraut @@aut@@ Marc H. Wadsworth @@aut@@ Travis K. Hughes @@aut@@ Humberto J. Ferreira @@aut@@ Emily Hinkley @@aut@@ Ines H. Kaltheuner @@aut@@ Matthias Geyer @@aut@@ Christoph Thiele @@aut@@ Alex K. Shalek @@aut@@ Andreas Feißt @@aut@@ Daniel Thomas @@aut@@ Henning Dickten @@aut@@ Marc Beyer @@aut@@ Patrick Baum @@aut@@ Nir Yosef @@aut@@ Anna C. Aschenbrenner @@aut@@ Thomas Ulas @@aut@@ Jan Hasenauer @@aut@@ Fabian J. Theis @@aut@@ Dirk Skowasch @@aut@@ Joachim L. Schultze @@aut@@ |
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Kevin Baßler |
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Kevin Baßler misc RC581-607 misc chronic obstructive pulmonary disease misc bronchoalveolar lavage misc blood misc macrophage misc monocyte misc impaired immune activation misc Immunologic diseases. Allergy Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation |
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RC581-607 Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation chronic obstructive pulmonary disease bronchoalveolar lavage blood macrophage monocyte impaired immune activation |
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misc RC581-607 misc chronic obstructive pulmonary disease misc bronchoalveolar lavage misc blood misc macrophage misc monocyte misc impaired immune activation misc Immunologic diseases. Allergy |
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Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation |
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Kevin Baßler Wataru Fujii Theodore S. Kapellos Erika Dudkin Nico Reusch Ari Horne Benedikt Reiz Malte D. Luecken Collins Osei-Sarpong Stefanie Warnat-Herresthal Lorenzo Bonaguro Jonas Schulte-Schrepping Allon Wagner Patrick Günther Carmen Pizarro Tina Schreiber Rainer Knoll Lisa Holsten Charlotte Kröger Elena De Domenico Matthias Becker Kristian Händler Christian T. Wohnhaas Florian Baumgartner Meike Köhler Heidi Theis Michael Kraut Marc H. Wadsworth Travis K. Hughes Humberto J. Ferreira Emily Hinkley Ines H. Kaltheuner Matthias Geyer Christoph Thiele Alex K. Shalek Andreas Feißt Daniel Thomas Henning Dickten Marc Beyer Patrick Baum Nir Yosef Anna C. Aschenbrenner Thomas Ulas Jan Hasenauer Fabian J. Theis Dirk Skowasch Joachim L. Schultze |
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alveolar macrophages in early stage copd show functional deviations with properties of impaired immune activation |
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Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation |
| abstract |
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation. |
| abstractGer |
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation. |
| abstract_unstemmed |
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation. |
| collection_details |
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| title_short |
Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation |
| url |
https://doi.org/10.3389/fimmu.2022.917232 https://doaj.org/article/e0f1f3d9372546f1a11d2fa5f19b33eb https://www.frontiersin.org/articles/10.3389/fimmu.2022.917232/full https://doaj.org/toc/1664-3224 |
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true |
| author2 |
Wataru Fujii Theodore S. Kapellos Erika Dudkin Nico Reusch Ari Horne Benedikt Reiz Malte D. Luecken Collins Osei-Sarpong Stefanie Warnat-Herresthal Lorenzo Bonaguro Jonas Schulte-Schrepping Allon Wagner Patrick Günther Carmen Pizarro Tina Schreiber Rainer Knoll Lisa Holsten Charlotte Kröger Elena De Domenico Matthias Becker Kristian Händler Christian T. Wohnhaas Florian Baumgartner Meike Köhler Heidi Theis Michael Kraut Marc H. Wadsworth Travis K. Hughes Humberto J. Ferreira Emily Hinkley Ines H. Kaltheuner Matthias Geyer Christoph Thiele Alex K. Shalek Andreas Feißt Daniel Thomas Henning Dickten Marc Beyer Patrick Baum Nir Yosef Anna C. Aschenbrenner Thomas Ulas Jan Hasenauer Fabian J. Theis Dirk Skowasch Joachim L. Schultze |
| author2Str |
Wataru Fujii Theodore S. Kapellos Erika Dudkin Nico Reusch Ari Horne Benedikt Reiz Malte D. Luecken Collins Osei-Sarpong Stefanie Warnat-Herresthal Lorenzo Bonaguro Jonas Schulte-Schrepping Allon Wagner Patrick Günther Carmen Pizarro Tina Schreiber Rainer Knoll Lisa Holsten Charlotte Kröger Elena De Domenico Matthias Becker Kristian Händler Christian T. Wohnhaas Florian Baumgartner Meike Köhler Heidi Theis Michael Kraut Marc H. Wadsworth Travis K. Hughes Humberto J. Ferreira Emily Hinkley Ines H. Kaltheuner Matthias Geyer Christoph Thiele Alex K. Shalek Andreas Feißt Daniel Thomas Henning Dickten Marc Beyer Patrick Baum Nir Yosef Anna C. Aschenbrenner Thomas Ulas Jan Hasenauer Fabian J. Theis Dirk Skowasch Joachim L. Schultze |
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657998354 |
| callnumber-subject |
RC - Internal Medicine |
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c |
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| doi_str |
10.3389/fimmu.2022.917232 |
| callnumber-a |
RC581-607 |
| up_date |
2024-07-03T22:27:10.448Z |
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