Plasmodium P36 determines host cell receptor usage during sporozoite invasion
Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite...
Ausführliche Beschreibung
Autor*in: |
Giulia Manzoni [verfasserIn] Carine Marinach [verfasserIn] Selma Topçu [verfasserIn] Sylvie Briquet [verfasserIn] Morgane Grand [verfasserIn] Matthieu Tolle [verfasserIn] Marion Gransagne [verfasserIn] Julien Lescar [verfasserIn] Chiara Andolina [verfasserIn] Jean-François Franetich [verfasserIn] Mirjam B Zeisel [verfasserIn] Thierry Huby [verfasserIn] Eric Rubinstein [verfasserIn] Georges Snounou [verfasserIn] Dominique Mazier [verfasserIn] François Nosten [verfasserIn] Thomas F Baumert [verfasserIn] Olivier Silvie [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2017 |
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Übergeordnetes Werk: |
In: eLife - eLife Sciences Publications Ltd, 2013, 6(2017) |
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Übergeordnetes Werk: |
volume:6 ; year:2017 |
Links: |
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DOI / URN: |
10.7554/eLife.25903 |
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Katalog-ID: |
DOAJ031818404 |
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520 | |a Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. | ||
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10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 |
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10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 |
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10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 |
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10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 |
allfieldsSound |
10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 |
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Giulia Manzoni @@aut@@ Carine Marinach @@aut@@ Selma Topçu @@aut@@ Sylvie Briquet @@aut@@ Morgane Grand @@aut@@ Matthieu Tolle @@aut@@ Marion Gransagne @@aut@@ Julien Lescar @@aut@@ Chiara Andolina @@aut@@ Jean-François Franetich @@aut@@ Mirjam B Zeisel @@aut@@ Thierry Huby @@aut@@ Eric Rubinstein @@aut@@ Georges Snounou @@aut@@ Dominique Mazier @@aut@@ François Nosten @@aut@@ Thomas F Baumert @@aut@@ Olivier Silvie @@aut@@ |
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2017-01-01T00:00:00Z |
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QH301-705.5 Plasmodium P36 determines host cell receptor usage during sporozoite invasion malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii |
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Plasmodium P36 determines host cell receptor usage during sporozoite invasion |
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Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. |
abstractGer |
Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. |
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Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. |
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Plasmodium P36 determines host cell receptor usage during sporozoite invasion |
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