Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite...
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Autor*in:	Giulia Manzoni [verfasserIn] Carine Marinach [verfasserIn] Selma Topçu [verfasserIn] Sylvie Briquet [verfasserIn] Morgane Grand [verfasserIn] Matthieu Tolle [verfasserIn] Marion Gransagne [verfasserIn] Julien Lescar [verfasserIn] Chiara Andolina [verfasserIn] Jean-François Franetich [verfasserIn] Mirjam B Zeisel [verfasserIn] Thierry Huby [verfasserIn] Eric Rubinstein [verfasserIn] Georges Snounou [verfasserIn] Dominique Mazier [verfasserIn] François Nosten [verfasserIn] Thomas F Baumert [verfasserIn] Olivier Silvie [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 6(2017)
Übergeordnetes Werk:	volume:6 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.25903

Katalog-ID:	DOAJ031818404

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allfields	10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
spelling	10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
allfields_unstemmed	10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
allfieldsGer	10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
allfieldsSound	10.7554/eLife.25903 doi (DE-627)DOAJ031818404 (DE-599)DOAJb4f9109adff8452b8f21f8a38e13c330 DE-627 ger DE-627 rakwb eng QH301-705.5 Giulia Manzoni verfasserin aut Plasmodium P36 determines host cell receptor usage during sporozoite invasion 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors. malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii Medicine R Science Q Biology (General) Carine Marinach verfasserin aut Selma Topçu verfasserin aut Sylvie Briquet verfasserin aut Morgane Grand verfasserin aut Matthieu Tolle verfasserin aut Marion Gransagne verfasserin aut Julien Lescar verfasserin aut Chiara Andolina verfasserin aut Jean-François Franetich verfasserin aut Mirjam B Zeisel verfasserin aut Thierry Huby verfasserin aut Eric Rubinstein verfasserin aut Georges Snounou verfasserin aut Dominique Mazier verfasserin aut François Nosten verfasserin aut Thomas F Baumert verfasserin aut Olivier Silvie verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.25903 kostenfrei https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 kostenfrei https://elifesciences.org/articles/25903 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
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callnumber-first	Q - Science
author	Giulia Manzoni
spellingShingle	Giulia Manzoni misc QH301-705.5 misc malaria misc hepatocyte misc sporozoite misc P. vivax misc P. berghei misc P. yoelii misc Medicine misc R misc Science misc Q misc Biology (General) Plasmodium P36 determines host cell receptor usage during sporozoite invasion
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topic_title	QH301-705.5 Plasmodium P36 determines host cell receptor usage during sporozoite invasion malaria hepatocyte sporozoite P. vivax P. berghei P. yoelii
topic	misc QH301-705.5 misc malaria misc hepatocyte misc sporozoite misc P. vivax misc P. berghei misc P. yoelii misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc malaria misc hepatocyte misc sporozoite misc P. vivax misc P. berghei misc P. yoelii misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Plasmodium P36 determines host cell receptor usage during sporozoite invasion
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title_full	Plasmodium P36 determines host cell receptor usage during sporozoite invasion
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author_browse	Giulia Manzoni Carine Marinach Selma Topçu Sylvie Briquet Morgane Grand Matthieu Tolle Marion Gransagne Julien Lescar Chiara Andolina Jean-François Franetich Mirjam B Zeisel Thierry Huby Eric Rubinstein Georges Snounou Dominique Mazier François Nosten Thomas F Baumert Olivier Silvie
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title_sort	plasmodium p36 determines host cell receptor usage during sporozoite invasion
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title_auth	Plasmodium P36 determines host cell receptor usage during sporozoite invasion
abstract	Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors.
abstractGer	Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors.
abstract_unstemmed	Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors.
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title_short	Plasmodium P36 determines host cell receptor usage during sporozoite invasion
url	https://doi.org/10.7554/eLife.25903 https://doaj.org/article/b4f9109adff8452b8f21f8a38e13c330 https://elifesciences.org/articles/25903 https://doaj.org/toc/2050-084X
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author2	Carine Marinach Selma Topçu Sylvie Briquet Morgane Grand Matthieu Tolle Marion Gransagne Julien Lescar Chiara Andolina Jean-François Franetich Mirjam B Zeisel Thierry Huby Eric Rubinstein Georges Snounou Dominique Mazier François Nosten Thomas F Baumert Olivier Silvie
author2Str	Carine Marinach Selma Topçu Sylvie Briquet Morgane Grand Matthieu Tolle Marion Gransagne Julien Lescar Chiara Andolina Jean-François Franetich Mirjam B Zeisel Thierry Huby Eric Rubinstein Georges Snounou Dominique Mazier François Nosten Thomas F Baumert Olivier Silvie
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doi_str	10.7554/eLife.25903
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up_date	2024-07-03T22:36:41.538Z
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Plasmodium P36 determines host cell receptor usage during sporozoite invasion

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