Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis

Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis o...
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Gespeichert in:

Autor*in:	Kerstin Seidel [verfasserIn] Pauline Marangoni [verfasserIn] Cynthia Tang [verfasserIn] Bahar Houshmand [verfasserIn] Wen Du [verfasserIn] Richard L Maas [verfasserIn] Steven Murray [verfasserIn] Michael C Oldham [verfasserIn] Ophir D Klein [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	stem cell incisor co-expression analysis lineage tracing

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 6(2017)
Übergeordnetes Werk:	volume:6 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.24712

Katalog-ID:	DOAJ031855199

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allfields	10.7554/eLife.24712 doi (DE-627)DOAJ031855199 (DE-599)DOAJfee6401a1b9f41a9a0c02bc68a6f2f2f DE-627 ger DE-627 rakwb eng QH301-705.5 Kerstin Seidel verfasserin aut Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity. stem cell incisor co-expression analysis lineage tracing Medicine R Science Q Biology (General) Pauline Marangoni verfasserin aut Cynthia Tang verfasserin aut Bahar Houshmand verfasserin aut Wen Du verfasserin aut Richard L Maas verfasserin aut Steven Murray verfasserin aut Michael C Oldham verfasserin aut Ophir D Klein verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.24712 kostenfrei https://doaj.org/article/fee6401a1b9f41a9a0c02bc68a6f2f2f kostenfrei https://elifesciences.org/articles/24712 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
spelling	10.7554/eLife.24712 doi (DE-627)DOAJ031855199 (DE-599)DOAJfee6401a1b9f41a9a0c02bc68a6f2f2f DE-627 ger DE-627 rakwb eng QH301-705.5 Kerstin Seidel verfasserin aut Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity. stem cell incisor co-expression analysis lineage tracing Medicine R Science Q Biology (General) Pauline Marangoni verfasserin aut Cynthia Tang verfasserin aut Bahar Houshmand verfasserin aut Wen Du verfasserin aut Richard L Maas verfasserin aut Steven Murray verfasserin aut Michael C Oldham verfasserin aut Ophir D Klein verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.24712 kostenfrei https://doaj.org/article/fee6401a1b9f41a9a0c02bc68a6f2f2f kostenfrei https://elifesciences.org/articles/24712 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
allfields_unstemmed	10.7554/eLife.24712 doi (DE-627)DOAJ031855199 (DE-599)DOAJfee6401a1b9f41a9a0c02bc68a6f2f2f DE-627 ger DE-627 rakwb eng QH301-705.5 Kerstin Seidel verfasserin aut Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity. stem cell incisor co-expression analysis lineage tracing Medicine R Science Q Biology (General) Pauline Marangoni verfasserin aut Cynthia Tang verfasserin aut Bahar Houshmand verfasserin aut Wen Du verfasserin aut Richard L Maas verfasserin aut Steven Murray verfasserin aut Michael C Oldham verfasserin aut Ophir D Klein verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.24712 kostenfrei https://doaj.org/article/fee6401a1b9f41a9a0c02bc68a6f2f2f kostenfrei https://elifesciences.org/articles/24712 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
allfieldsGer	10.7554/eLife.24712 doi (DE-627)DOAJ031855199 (DE-599)DOAJfee6401a1b9f41a9a0c02bc68a6f2f2f DE-627 ger DE-627 rakwb eng QH301-705.5 Kerstin Seidel verfasserin aut Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity. stem cell incisor co-expression analysis lineage tracing Medicine R Science Q Biology (General) Pauline Marangoni verfasserin aut Cynthia Tang verfasserin aut Bahar Houshmand verfasserin aut Wen Du verfasserin aut Richard L Maas verfasserin aut Steven Murray verfasserin aut Michael C Oldham verfasserin aut Ophir D Klein verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.24712 kostenfrei https://doaj.org/article/fee6401a1b9f41a9a0c02bc68a6f2f2f kostenfrei https://elifesciences.org/articles/24712 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
allfieldsSound	10.7554/eLife.24712 doi (DE-627)DOAJ031855199 (DE-599)DOAJfee6401a1b9f41a9a0c02bc68a6f2f2f DE-627 ger DE-627 rakwb eng QH301-705.5 Kerstin Seidel verfasserin aut Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity. stem cell incisor co-expression analysis lineage tracing Medicine R Science Q Biology (General) Pauline Marangoni verfasserin aut Cynthia Tang verfasserin aut Bahar Houshmand verfasserin aut Wen Du verfasserin aut Richard L Maas verfasserin aut Steven Murray verfasserin aut Michael C Oldham verfasserin aut Ophir D Klein verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 6(2017) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:6 year:2017 https://doi.org/10.7554/eLife.24712 kostenfrei https://doaj.org/article/fee6401a1b9f41a9a0c02bc68a6f2f2f kostenfrei https://elifesciences.org/articles/24712 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017
language	English
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container_title	eLife
authorswithroles_txt_mv	Kerstin Seidel @@aut@@ Pauline Marangoni @@aut@@ Cynthia Tang @@aut@@ Bahar Houshmand @@aut@@ Wen Du @@aut@@ Richard L Maas @@aut@@ Steven Murray @@aut@@ Michael C Oldham @@aut@@ Ophir D Klein @@aut@@
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author	Kerstin Seidel
spellingShingle	Kerstin Seidel misc QH301-705.5 misc stem cell misc incisor misc co-expression analysis misc lineage tracing misc Medicine misc R misc Science misc Q misc Biology (General) Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis
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topic_title	QH301-705.5 Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis stem cell incisor co-expression analysis lineage tracing
topic	misc QH301-705.5 misc stem cell misc incisor misc co-expression analysis misc lineage tracing misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis
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title_full	Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis
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title_sort	resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis
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title_auth	Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis
abstract	Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity.
abstractGer	Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity.
abstract_unstemmed	Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells. We further discovered that two adjacent mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem cells. These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression analysis of intact biological systems can provide insights into the transcriptional basis of cellular identity.
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title_short	Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis
url	https://doi.org/10.7554/eLife.24712 https://doaj.org/article/fee6401a1b9f41a9a0c02bc68a6f2f2f https://elifesciences.org/articles/24712 https://doaj.org/toc/2050-084X
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Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis

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