SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo. A remarkable feature of the severe acute resp...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Anna Z Mykytyn [verfasserIn]

Tim I Breugem [verfasserIn]

Samra Riesebosch [verfasserIn]

Debby Schipper [verfasserIn]

Petra B van den Doel [verfasserIn]

Robbert J Rottier [verfasserIn]

Mart M Lamers [verfasserIn]

Bart L Haagmans [verfasserIn]

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2021

Schlagwörter:

COVID-19

SARS-CoV-2

SARS-CoV

multibasic cleavage site

serine proteases

airway organoids

Übergeordnetes Werk:

In: eLife - eLife Sciences Publications Ltd, 2013, 10(2021)

Übergeordnetes Werk:

volume:10 ; year:2021

Links:

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Journal toc

DOI / URN:

10.7554/eLife.64508

Katalog-ID:

DOAJ032070772

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