Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study.

<h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical feat...
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Autor*in:	Yuga Komaki [verfasserIn] Shuji Kanmura [verfasserIn] Kazuki Yutsudo [verfasserIn] Kosuke Kuwazuru [verfasserIn] Fukiko Komaki [verfasserIn] Akihito Tanaka [verfasserIn] Hidehito Maeda [verfasserIn] Shiho Arima [verfasserIn] Shiroh Tanoue [verfasserIn] Fumisato Sasaki [verfasserIn] Shinichi Hashimoto [verfasserIn] Masahisa Horiuchi [verfasserIn] Akio Ido [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 17(2022), 3, p e0265903
Übergeordnetes Werk:	volume:17 ; year:2022 ; number:3, p e0265903

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0265903

Katalog-ID:	DOAJ032355882

Internformat


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245	1	0	\|a Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study.
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520			\|a <h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively.
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700	0		\|a Akio Ido \|e verfasserin \|4 aut
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allfields	10.1371/journal.pone.0265903 doi (DE-627)DOAJ032355882 (DE-599)DOAJ4f394d04aeee47c6b46d27a682fa6a2d DE-627 ger DE-627 rakwb eng Yuga Komaki verfasserin aut Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively. Medicine R Science Q Shuji Kanmura verfasserin aut Kazuki Yutsudo verfasserin aut Kosuke Kuwazuru verfasserin aut Fukiko Komaki verfasserin aut Akihito Tanaka verfasserin aut Hidehito Maeda verfasserin aut Shiho Arima verfasserin aut Shiroh Tanoue verfasserin aut Fumisato Sasaki verfasserin aut Shinichi Hashimoto verfasserin aut Masahisa Horiuchi verfasserin aut Akio Ido verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 17(2022), 3, p e0265903 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:17 year:2022 number:3, p e0265903 https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/article/4f394d04aeee47c6b46d27a682fa6a2d kostenfrei https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3, p e0265903
spelling	10.1371/journal.pone.0265903 doi (DE-627)DOAJ032355882 (DE-599)DOAJ4f394d04aeee47c6b46d27a682fa6a2d DE-627 ger DE-627 rakwb eng Yuga Komaki verfasserin aut Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively. Medicine R Science Q Shuji Kanmura verfasserin aut Kazuki Yutsudo verfasserin aut Kosuke Kuwazuru verfasserin aut Fukiko Komaki verfasserin aut Akihito Tanaka verfasserin aut Hidehito Maeda verfasserin aut Shiho Arima verfasserin aut Shiroh Tanoue verfasserin aut Fumisato Sasaki verfasserin aut Shinichi Hashimoto verfasserin aut Masahisa Horiuchi verfasserin aut Akio Ido verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 17(2022), 3, p e0265903 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:17 year:2022 number:3, p e0265903 https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/article/4f394d04aeee47c6b46d27a682fa6a2d kostenfrei https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3, p e0265903
allfields_unstemmed	10.1371/journal.pone.0265903 doi (DE-627)DOAJ032355882 (DE-599)DOAJ4f394d04aeee47c6b46d27a682fa6a2d DE-627 ger DE-627 rakwb eng Yuga Komaki verfasserin aut Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively. Medicine R Science Q Shuji Kanmura verfasserin aut Kazuki Yutsudo verfasserin aut Kosuke Kuwazuru verfasserin aut Fukiko Komaki verfasserin aut Akihito Tanaka verfasserin aut Hidehito Maeda verfasserin aut Shiho Arima verfasserin aut Shiroh Tanoue verfasserin aut Fumisato Sasaki verfasserin aut Shinichi Hashimoto verfasserin aut Masahisa Horiuchi verfasserin aut Akio Ido verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 17(2022), 3, p e0265903 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:17 year:2022 number:3, p e0265903 https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/article/4f394d04aeee47c6b46d27a682fa6a2d kostenfrei https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3, p e0265903
allfieldsGer	10.1371/journal.pone.0265903 doi (DE-627)DOAJ032355882 (DE-599)DOAJ4f394d04aeee47c6b46d27a682fa6a2d DE-627 ger DE-627 rakwb eng Yuga Komaki verfasserin aut Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively. Medicine R Science Q Shuji Kanmura verfasserin aut Kazuki Yutsudo verfasserin aut Kosuke Kuwazuru verfasserin aut Fukiko Komaki verfasserin aut Akihito Tanaka verfasserin aut Hidehito Maeda verfasserin aut Shiho Arima verfasserin aut Shiroh Tanoue verfasserin aut Fumisato Sasaki verfasserin aut Shinichi Hashimoto verfasserin aut Masahisa Horiuchi verfasserin aut Akio Ido verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 17(2022), 3, p e0265903 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:17 year:2022 number:3, p e0265903 https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/article/4f394d04aeee47c6b46d27a682fa6a2d kostenfrei https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3, p e0265903
allfieldsSound	10.1371/journal.pone.0265903 doi (DE-627)DOAJ032355882 (DE-599)DOAJ4f394d04aeee47c6b46d27a682fa6a2d DE-627 ger DE-627 rakwb eng Yuga Komaki verfasserin aut Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively. Medicine R Science Q Shuji Kanmura verfasserin aut Kazuki Yutsudo verfasserin aut Kosuke Kuwazuru verfasserin aut Fukiko Komaki verfasserin aut Akihito Tanaka verfasserin aut Hidehito Maeda verfasserin aut Shiho Arima verfasserin aut Shiroh Tanoue verfasserin aut Fumisato Sasaki verfasserin aut Shinichi Hashimoto verfasserin aut Masahisa Horiuchi verfasserin aut Akio Ido verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 17(2022), 3, p e0265903 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:17 year:2022 number:3, p e0265903 https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/article/4f394d04aeee47c6b46d27a682fa6a2d kostenfrei https://doi.org/10.1371/journal.pone.0265903 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3, p e0265903
language	English
source	In PLoS ONE 17(2022), 3, p e0265903 volume:17 year:2022 number:3, p e0265903
sourceStr	In PLoS ONE 17(2022), 3, p e0265903 volume:17 year:2022 number:3, p e0265903
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Yuga Komaki @@aut@@ Shuji Kanmura @@aut@@ Kazuki Yutsudo @@aut@@ Kosuke Kuwazuru @@aut@@ Fukiko Komaki @@aut@@ Akihito Tanaka @@aut@@ Hidehito Maeda @@aut@@ Shiho Arima @@aut@@ Shiroh Tanoue @@aut@@ Fumisato Sasaki @@aut@@ Shinichi Hashimoto @@aut@@ Masahisa Horiuchi @@aut@@ Akio Ido @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ032355882
language_de	englisch
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author	Yuga Komaki
spellingShingle	Yuga Komaki misc Medicine misc R misc Science misc Q Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study.
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topic_title	Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study
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title	Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study.
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title_full	Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study
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author_browse	Yuga Komaki Shuji Kanmura Kazuki Yutsudo Kosuke Kuwazuru Fukiko Komaki Akihito Tanaka Hidehito Maeda Shiho Arima Shiroh Tanoue Fumisato Sasaki Shinichi Hashimoto Masahisa Horiuchi Akio Ido
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title_sort	clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: a retrospective cohort study
title_auth	Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study.
abstract	<h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively.
abstractGer	<h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively.
abstract_unstemmed	<h4<Background</h4<Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear.<h4<Aim</h4<We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital.<h4<Methods</h4<We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis.<h4<Results</h4<The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010).<h4<Conclusions</h4<Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively.
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title_short	Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study.
url	https://doi.org/10.1371/journal.pone.0265903 https://doaj.org/article/4f394d04aeee47c6b46d27a682fa6a2d https://doaj.org/toc/1932-6203
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author2Str	Shuji Kanmura Kazuki Yutsudo Kosuke Kuwazuru Fukiko Komaki Akihito Tanaka Hidehito Maeda Shiho Arima Shiroh Tanoue Fumisato Sasaki Shinichi Hashimoto Masahisa Horiuchi Akio Ido
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up_date	2024-07-04T00:54:54.301Z
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Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study.

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