COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona...
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Gespeichert in:

Autor*in:	Giovanni Lentini [verfasserIn] Maria Maddalena Cavalluzzi [verfasserIn] Solomon Habtemariam [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	SARS-CoV-2 COVID-19 2019-nCoV SARS chiral switch MERS

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 25(2020), 8, p 1834
Übergeordnetes Werk:	volume:25 ; year:2020 ; number:8, p 1834

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules25081834

Katalog-ID:	DOAJ032378173

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allfieldsGer	10.3390/molecules25081834 doi (DE-627)DOAJ032378173 (DE-599)DOAJ57e63b4539ca49289d41171c9fab4a6d DE-627 ger DE-627 rakwb eng QD241-441 Giovanni Lentini verfasserin aut COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate. SARS-CoV-2 COVID-19 2019-nCoV SARS chiral switch MERS Organic chemistry Maria Maddalena Cavalluzzi verfasserin aut Solomon Habtemariam verfasserin aut In Molecules MDPI AG, 2003 25(2020), 8, p 1834 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:8, p 1834 https://doi.org/10.3390/molecules25081834 kostenfrei https://doaj.org/article/57e63b4539ca49289d41171c9fab4a6d kostenfrei https://www.mdpi.com/1420-3049/25/8/1834 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 8, p 1834
allfieldsSound	10.3390/molecules25081834 doi (DE-627)DOAJ032378173 (DE-599)DOAJ57e63b4539ca49289d41171c9fab4a6d DE-627 ger DE-627 rakwb eng QD241-441 Giovanni Lentini verfasserin aut COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate. SARS-CoV-2 COVID-19 2019-nCoV SARS chiral switch MERS Organic chemistry Maria Maddalena Cavalluzzi verfasserin aut Solomon Habtemariam verfasserin aut In Molecules MDPI AG, 2003 25(2020), 8, p 1834 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:8, p 1834 https://doi.org/10.3390/molecules25081834 kostenfrei https://doaj.org/article/57e63b4539ca49289d41171c9fab4a6d kostenfrei https://www.mdpi.com/1420-3049/25/8/1834 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 8, p 1834
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source	In Molecules 25(2020), 8, p 1834 volume:25 year:2020 number:8, p 1834
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authorswithroles_txt_mv	Giovanni Lentini @@aut@@ Maria Maddalena Cavalluzzi @@aut@@ Solomon Habtemariam @@aut@@
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callnumber-first	Q - Science
author	Giovanni Lentini
spellingShingle	Giovanni Lentini misc QD241-441 misc SARS-CoV-2 misc COVID-19 misc 2019-nCoV misc SARS misc chiral switch misc MERS misc Organic chemistry COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help
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topic_title	QD241-441 COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help SARS-CoV-2 COVID-19 2019-nCoV SARS chiral switch MERS
topic	misc QD241-441 misc SARS-CoV-2 misc COVID-19 misc 2019-nCoV misc SARS misc chiral switch misc MERS misc Organic chemistry
topic_unstemmed	misc QD241-441 misc SARS-CoV-2 misc COVID-19 misc 2019-nCoV misc SARS misc chiral switch misc MERS misc Organic chemistry
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title_sort	covid-19, chloroquine repurposing, and cardiac safety concern: chirality might help
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title_auth	COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help
abstract	The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate.
abstractGer	The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate.
abstract_unstemmed	The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate.
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title_short	COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help
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score	7.401602

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