Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction

Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficking of TG2 at the cell surfa...
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Gespeichert in:

Autor*in:	Giulia Furini [verfasserIn] Elisabetta A.M. Verderio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	transglutaminase-2 (TG2) heparan sulfate proteoglycans (HSPGs) syndecan-4 (Sdc4) fibrosis

Übergeordnetes Werk:	In: Medical Sciences - MDPI AG, 2014, 7(2019), 1, p 5
Übergeordnetes Werk:	volume:7 ; year:2019 ; number:1, p 5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/medsci7010005

Katalog-ID:	DOAJ032411618

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spelling	10.3390/medsci7010005 doi (DE-627)DOAJ032411618 (DE-599)DOAJb5a1019809c14540a6c6a6d6d192ecef DE-627 ger DE-627 rakwb eng Giulia Furini verfasserin aut Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficking of TG2 at the cell surface and in the extracellular matrix (ECM) has been linked to the fibrogenic action of TG2 in experimental models of kidney fibrosis. As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks. In this review, we aim to provide a compendium of the main literature available on the interaction of TG2 with HS, with reference to the pathological processes in which extracellular TG2 plays a role. transglutaminase-2 (TG2) heparan sulfate proteoglycans (HSPGs) syndecan-4 (Sdc4) fibrosis Medicine R Elisabetta A.M. Verderio verfasserin aut In Medical Sciences MDPI AG, 2014 7(2019), 1, p 5 (DE-627)77777965X (DE-600)2754473-4 20763271 nnns volume:7 year:2019 number:1, p 5 https://doi.org/10.3390/medsci7010005 kostenfrei https://doaj.org/article/b5a1019809c14540a6c6a6d6d192ecef kostenfrei http://www.mdpi.com/2076-3271/7/1/5 kostenfrei https://doaj.org/toc/2076-3271 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1, p 5
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author	Giulia Furini
spellingShingle	Giulia Furini misc transglutaminase-2 (TG2) misc heparan sulfate proteoglycans (HSPGs) misc syndecan-4 (Sdc4) misc fibrosis misc Medicine misc R Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction
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topic_title	Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction transglutaminase-2 (TG2) heparan sulfate proteoglycans (HSPGs) syndecan-4 (Sdc4) fibrosis
topic	misc transglutaminase-2 (TG2) misc heparan sulfate proteoglycans (HSPGs) misc syndecan-4 (Sdc4) misc fibrosis misc Medicine misc R
topic_unstemmed	misc transglutaminase-2 (TG2) misc heparan sulfate proteoglycans (HSPGs) misc syndecan-4 (Sdc4) misc fibrosis misc Medicine misc R
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title	Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction
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title_sort	spotlight on the transglutaminase 2-heparan sulfate interaction
title_auth	Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction
abstract	Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficking of TG2 at the cell surface and in the extracellular matrix (ECM) has been linked to the fibrogenic action of TG2 in experimental models of kidney fibrosis. As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks. In this review, we aim to provide a compendium of the main literature available on the interaction of TG2 with HS, with reference to the pathological processes in which extracellular TG2 plays a role.
abstractGer	Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficking of TG2 at the cell surface and in the extracellular matrix (ECM) has been linked to the fibrogenic action of TG2 in experimental models of kidney fibrosis. As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks. In this review, we aim to provide a compendium of the main literature available on the interaction of TG2 with HS, with reference to the pathological processes in which extracellular TG2 plays a role.
abstract_unstemmed	Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficking of TG2 at the cell surface and in the extracellular matrix (ECM) has been linked to the fibrogenic action of TG2 in experimental models of kidney fibrosis. As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks. In this review, we aim to provide a compendium of the main literature available on the interaction of TG2 with HS, with reference to the pathological processes in which extracellular TG2 plays a role.
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title_short	Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction
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