Gut microbiota in chronic kidney disease

The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared t...
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Autor*in:	Secundino Cigarran Guldris [verfasserIn] Emilio González Parra [verfasserIn] Aleix Cases Amenós [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Chronic kidney disease Gut microbiota Dysbiosis Uraemic toxins Inflammation

Übergeordnetes Werk:	In: Nefrología (English Edition) - Elsevier, 2017, 37(2017), 1, Seite 9-19
Übergeordnetes Werk:	volume:37 ; year:2017 ; number:1 ; pages:9-19

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nefroe.2017.01.017

Katalog-ID:	DOAJ032614462

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allfields	10.1016/j.nefroe.2017.01.017 doi (DE-627)DOAJ032614462 (DE-599)DOAJ0e678bdba96048d49bf7e735e21c5684 DE-627 ger DE-627 rakwb eng RC870-923 Secundino Cigarran Guldris verfasserin aut Gut microbiota in chronic kidney disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications. Chronic kidney disease Gut microbiota Dysbiosis Uraemic toxins Inflammation Diseases of the genitourinary system. Urology Emilio González Parra verfasserin aut Aleix Cases Amenós verfasserin aut In Nefrología (English Edition) Elsevier, 2017 37(2017), 1, Seite 9-19 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:37 year:2017 number:1 pages:9-19 https://doi.org/10.1016/j.nefroe.2017.01.017 kostenfrei https://doaj.org/article/0e678bdba96048d49bf7e735e21c5684 kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251417300202 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 1 9-19
spelling	10.1016/j.nefroe.2017.01.017 doi (DE-627)DOAJ032614462 (DE-599)DOAJ0e678bdba96048d49bf7e735e21c5684 DE-627 ger DE-627 rakwb eng RC870-923 Secundino Cigarran Guldris verfasserin aut Gut microbiota in chronic kidney disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications. Chronic kidney disease Gut microbiota Dysbiosis Uraemic toxins Inflammation Diseases of the genitourinary system. Urology Emilio González Parra verfasserin aut Aleix Cases Amenós verfasserin aut In Nefrología (English Edition) Elsevier, 2017 37(2017), 1, Seite 9-19 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:37 year:2017 number:1 pages:9-19 https://doi.org/10.1016/j.nefroe.2017.01.017 kostenfrei https://doaj.org/article/0e678bdba96048d49bf7e735e21c5684 kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251417300202 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 1 9-19
allfields_unstemmed	10.1016/j.nefroe.2017.01.017 doi (DE-627)DOAJ032614462 (DE-599)DOAJ0e678bdba96048d49bf7e735e21c5684 DE-627 ger DE-627 rakwb eng RC870-923 Secundino Cigarran Guldris verfasserin aut Gut microbiota in chronic kidney disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications. Chronic kidney disease Gut microbiota Dysbiosis Uraemic toxins Inflammation Diseases of the genitourinary system. Urology Emilio González Parra verfasserin aut Aleix Cases Amenós verfasserin aut In Nefrología (English Edition) Elsevier, 2017 37(2017), 1, Seite 9-19 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:37 year:2017 number:1 pages:9-19 https://doi.org/10.1016/j.nefroe.2017.01.017 kostenfrei https://doaj.org/article/0e678bdba96048d49bf7e735e21c5684 kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251417300202 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 1 9-19
allfieldsGer	10.1016/j.nefroe.2017.01.017 doi (DE-627)DOAJ032614462 (DE-599)DOAJ0e678bdba96048d49bf7e735e21c5684 DE-627 ger DE-627 rakwb eng RC870-923 Secundino Cigarran Guldris verfasserin aut Gut microbiota in chronic kidney disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications. Chronic kidney disease Gut microbiota Dysbiosis Uraemic toxins Inflammation Diseases of the genitourinary system. Urology Emilio González Parra verfasserin aut Aleix Cases Amenós verfasserin aut In Nefrología (English Edition) Elsevier, 2017 37(2017), 1, Seite 9-19 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:37 year:2017 number:1 pages:9-19 https://doi.org/10.1016/j.nefroe.2017.01.017 kostenfrei https://doaj.org/article/0e678bdba96048d49bf7e735e21c5684 kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251417300202 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 1 9-19
allfieldsSound	10.1016/j.nefroe.2017.01.017 doi (DE-627)DOAJ032614462 (DE-599)DOAJ0e678bdba96048d49bf7e735e21c5684 DE-627 ger DE-627 rakwb eng RC870-923 Secundino Cigarran Guldris verfasserin aut Gut microbiota in chronic kidney disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications. Chronic kidney disease Gut microbiota Dysbiosis Uraemic toxins Inflammation Diseases of the genitourinary system. Urology Emilio González Parra verfasserin aut Aleix Cases Amenós verfasserin aut In Nefrología (English Edition) Elsevier, 2017 37(2017), 1, Seite 9-19 (DE-627)837956323 (DE-600)2837917-2 20132514 nnns volume:37 year:2017 number:1 pages:9-19 https://doi.org/10.1016/j.nefroe.2017.01.017 kostenfrei https://doaj.org/article/0e678bdba96048d49bf7e735e21c5684 kostenfrei http://www.sciencedirect.com/science/article/pii/S2013251417300202 kostenfrei https://doaj.org/toc/2013-2514 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 1 9-19
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author	Secundino Cigarran Guldris
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topic_title	RC870-923 Gut microbiota in chronic kidney disease Chronic kidney disease Gut microbiota Dysbiosis Uraemic toxins Inflammation
topic	misc RC870-923 misc Chronic kidney disease misc Gut microbiota misc Dysbiosis misc Uraemic toxins misc Inflammation misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Chronic kidney disease misc Gut microbiota misc Dysbiosis misc Uraemic toxins misc Inflammation misc Diseases of the genitourinary system. Urology
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title	Gut microbiota in chronic kidney disease
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title_auth	Gut microbiota in chronic kidney disease
abstract	The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications.
abstractGer	The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications.
abstract_unstemmed	The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been associated with several diseases. In chronic kidney disease (CKD), dysbiotic intestinal microflora has been reported with an increase in pathogenic flora compared to symbiotic flora. An enhanced permeability of the intestinal barrier, allowing the passage of endotoxins and other bacterial products to the blood, has also been shown in CKD. By fermenting undigested products that reach the colon, the intestinal microflora produce indoles, phenols and amines, among others, that are absorbed by the host, accumulate in CKD and have harmful effects on the body. These gut-derived uraemic toxins and the increased permeability of the intestinal barrier in CKD have been associated with increased inflammation and oxidative stress and have been involved in various CKD-related complications, including cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intestinal barrier and its clinical consequences, the harmful effects of intestinal flora-derived uraemic toxins, and possible therapeutic options to improve this dysbiosis and reduce CKD-related complications.
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