Diverse functions of matrix metalloproteinases during fibrosis

Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix metalloproteinases (MMPs), might be expected to be under-expr...
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Autor*in:	Matthew Giannandrea [verfasserIn] William C. Parks [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Fibrosis Extracellular matrix Collagen Metalloproteinase TIMP

Übergeordnetes Werk:	In: Disease Models & Mechanisms - The Company of Biologists, 2011, 7(2014), 2, Seite 193-203
Übergeordnetes Werk:	volume:7 ; year:2014 ; number:2 ; pages:193-203

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1242/dmm.012062

Katalog-ID:	DOAJ032682026

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520			\|a Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix metalloproteinases (MMPs), might be expected to be under-expressed in fibrosis or, if present, could function to resolve the excess matrix. However, as we review here, some MMPs are indeed anti-fibrotic, whereas others can have pro-fibrotic functions. MMPs modulate a range of biological processes, especially processes related to immunity and tissue repair and/or remodeling. Although we do not yet know precisely how MMPs function during fibrosis – that is, the protein substrate or substrates that an individual MMP acts on to effect a specific process – experiments in mouse models demonstrate that MMP-dependent functions during fibrosis are not limited to effects on ECM turnover. Rather, data from diverse models indicate that these proteinases influence cellular activities as varied as proliferation and survival, gene expression, and multiple aspects of inflammation that, in turn, impact outcomes related to fibrosis.
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source	In Disease Models & Mechanisms 7(2014), 2, Seite 193-203 volume:7 year:2014 number:2 pages:193-203
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topic_facet	Fibrosis Extracellular matrix Collagen Metalloproteinase TIMP Medicine R Pathology
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container_title	Disease Models & Mechanisms
authorswithroles_txt_mv	Matthew Giannandrea @@aut@@ William C. Parks @@aut@@
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title_sort	diverse functions of matrix metalloproteinases during fibrosis
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title_auth	Diverse functions of matrix metalloproteinases during fibrosis
abstract	Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix metalloproteinases (MMPs), might be expected to be under-expressed in fibrosis or, if present, could function to resolve the excess matrix. However, as we review here, some MMPs are indeed anti-fibrotic, whereas others can have pro-fibrotic functions. MMPs modulate a range of biological processes, especially processes related to immunity and tissue repair and/or remodeling. Although we do not yet know precisely how MMPs function during fibrosis – that is, the protein substrate or substrates that an individual MMP acts on to effect a specific process – experiments in mouse models demonstrate that MMP-dependent functions during fibrosis are not limited to effects on ECM turnover. Rather, data from diverse models indicate that these proteinases influence cellular activities as varied as proliferation and survival, gene expression, and multiple aspects of inflammation that, in turn, impact outcomes related to fibrosis.
abstractGer	Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix metalloproteinases (MMPs), might be expected to be under-expressed in fibrosis or, if present, could function to resolve the excess matrix. However, as we review here, some MMPs are indeed anti-fibrotic, whereas others can have pro-fibrotic functions. MMPs modulate a range of biological processes, especially processes related to immunity and tissue repair and/or remodeling. Although we do not yet know precisely how MMPs function during fibrosis – that is, the protein substrate or substrates that an individual MMP acts on to effect a specific process – experiments in mouse models demonstrate that MMP-dependent functions during fibrosis are not limited to effects on ECM turnover. Rather, data from diverse models indicate that these proteinases influence cellular activities as varied as proliferation and survival, gene expression, and multiple aspects of inflammation that, in turn, impact outcomes related to fibrosis.
abstract_unstemmed	Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix metalloproteinases (MMPs), might be expected to be under-expressed in fibrosis or, if present, could function to resolve the excess matrix. However, as we review here, some MMPs are indeed anti-fibrotic, whereas others can have pro-fibrotic functions. MMPs modulate a range of biological processes, especially processes related to immunity and tissue repair and/or remodeling. Although we do not yet know precisely how MMPs function during fibrosis – that is, the protein substrate or substrates that an individual MMP acts on to effect a specific process – experiments in mouse models demonstrate that MMP-dependent functions during fibrosis are not limited to effects on ECM turnover. Rather, data from diverse models indicate that these proteinases influence cellular activities as varied as proliferation and survival, gene expression, and multiple aspects of inflammation that, in turn, impact outcomes related to fibrosis.
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title_short	Diverse functions of matrix metalloproteinases during fibrosis
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