Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review

An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the...
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Autor*in:	Kei Kawaguchi [verfasserIn] Qinghong Han [verfasserIn] Shukuan Li [verfasserIn] Yuying Tan [verfasserIn] Kentaro Igarashi [verfasserIn] Takashi Murakami [verfasserIn] Michiaki Unno [verfasserIn] Robert M. Hoffman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	recombinant methioninase methionine dependence nude mice orthotopic implantation patient-derived tumor

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 8(2019), 5, p 410
Übergeordnetes Werk:	volume:8 ; year:2019 ; number:5, p 410

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells8050410

Katalog-ID:	DOAJ032750560

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allfields	10.3390/cells8050410 doi (DE-627)DOAJ032750560 (DE-599)DOAJ3787b8b17e1445f2bbf7773c56eeff06 DE-627 ger DE-627 rakwb eng QH301-705.5 Kei Kawaguchi verfasserin aut Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G<sub<2</sub< phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective. recombinant methioninase methionine dependence nude mice orthotopic implantation patient-derived tumor Biology (General) Qinghong Han verfasserin aut Shukuan Li verfasserin aut Yuying Tan verfasserin aut Kentaro Igarashi verfasserin aut Takashi Murakami verfasserin aut Michiaki Unno verfasserin aut Robert M. Hoffman verfasserin aut In Cells MDPI AG, 2012 8(2019), 5, p 410 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:8 year:2019 number:5, p 410 https://doi.org/10.3390/cells8050410 kostenfrei https://doaj.org/article/3787b8b17e1445f2bbf7773c56eeff06 kostenfrei https://www.mdpi.com/2073-4409/8/5/410 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 5, p 410
spelling	10.3390/cells8050410 doi (DE-627)DOAJ032750560 (DE-599)DOAJ3787b8b17e1445f2bbf7773c56eeff06 DE-627 ger DE-627 rakwb eng QH301-705.5 Kei Kawaguchi verfasserin aut Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G<sub<2</sub< phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective. recombinant methioninase methionine dependence nude mice orthotopic implantation patient-derived tumor Biology (General) Qinghong Han verfasserin aut Shukuan Li verfasserin aut Yuying Tan verfasserin aut Kentaro Igarashi verfasserin aut Takashi Murakami verfasserin aut Michiaki Unno verfasserin aut Robert M. Hoffman verfasserin aut In Cells MDPI AG, 2012 8(2019), 5, p 410 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:8 year:2019 number:5, p 410 https://doi.org/10.3390/cells8050410 kostenfrei https://doaj.org/article/3787b8b17e1445f2bbf7773c56eeff06 kostenfrei https://www.mdpi.com/2073-4409/8/5/410 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 5, p 410
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language	English
source	In Cells 8(2019), 5, p 410 volume:8 year:2019 number:5, p 410
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topic_facet	recombinant methioninase methionine dependence nude mice orthotopic implantation patient-derived tumor Biology (General)
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container_title	Cells
authorswithroles_txt_mv	Kei Kawaguchi @@aut@@ Qinghong Han @@aut@@ Shukuan Li @@aut@@ Yuying Tan @@aut@@ Kentaro Igarashi @@aut@@ Takashi Murakami @@aut@@ Michiaki Unno @@aut@@ Robert M. Hoffman @@aut@@
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callnumber-first	Q - Science
author	Kei Kawaguchi
spellingShingle	Kei Kawaguchi misc QH301-705.5 misc recombinant methioninase misc methionine dependence misc nude mice misc orthotopic implantation misc patient-derived tumor misc Biology (General) Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
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topic_title	QH301-705.5 Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review recombinant methioninase methionine dependence nude mice orthotopic implantation patient-derived tumor
topic	misc QH301-705.5 misc recombinant methioninase misc methionine dependence misc nude mice misc orthotopic implantation misc patient-derived tumor misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc recombinant methioninase misc methionine dependence misc nude mice misc orthotopic implantation misc patient-derived tumor misc Biology (General)
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title	Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
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title_full	Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
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author_browse	Kei Kawaguchi Qinghong Han Shukuan Li Yuying Tan Kentaro Igarashi Takashi Murakami Michiaki Unno Robert M. Hoffman
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title_sort	efficacy of recombinant methioninase (rmetase) on recalcitrant cancer patient-derived orthotopic xenograft (pdox) mouse models: a review
callnumber	QH301-705.5
title_auth	Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
abstract	An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G<sub<2</sub< phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective.
abstractGer	An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G<sub<2</sub< phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective.
abstract_unstemmed	An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G<sub<2</sub< phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective.
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container_issue	5, p 410
title_short	Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
url	https://doi.org/10.3390/cells8050410 https://doaj.org/article/3787b8b17e1445f2bbf7773c56eeff06 https://www.mdpi.com/2073-4409/8/5/410 https://doaj.org/toc/2073-4409
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Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review

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