Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial

Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the e...
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Autor*in:	Muriel Vicent-Gil [verfasserIn] Beatriz Raventós [verfasserIn] Eduardo D. Marín-Martínez [verfasserIn] Sara González-Simarro [verfasserIn] Anabel Martínez-Arán [verfasserIn] Caterina del Mar Bonnin [verfasserIn] Joan Trujols [verfasserIn] Josefina Pérez-Blanco [verfasserIn] Javier de Diego-Adeliño [verfasserIn] Dolors Puigdemont [verfasserIn] Maria Serra-Blasco [verfasserIn] Narcís Cardoner [verfasserIn] Maria J. Portella [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Cognitive remediation Depression Functional remediation Computerized cognitive training Clinical trial

Übergeordnetes Werk:	In: BMC Psychiatry - BMC, 2003, 19(2019), 1, Seite 8
Übergeordnetes Werk:	volume:19 ; year:2019 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12888-019-2117-4

Katalog-ID:	DOAJ032985010

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520			\|a Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018.
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spelling	10.1186/s12888-019-2117-4 doi (DE-627)DOAJ032985010 (DE-599)DOAJ75541a74e9bb40dc8d292240a222a5a4 DE-627 ger DE-627 rakwb eng RC435-571 Muriel Vicent-Gil verfasserin aut Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018. Cognitive remediation Depression Functional remediation Computerized cognitive training Clinical trial Psychiatry Beatriz Raventós verfasserin aut Eduardo D. Marín-Martínez verfasserin aut Sara González-Simarro verfasserin aut Anabel Martínez-Arán verfasserin aut Caterina del Mar Bonnin verfasserin aut Joan Trujols verfasserin aut Josefina Pérez-Blanco verfasserin aut Javier de Diego-Adeliño verfasserin aut Dolors Puigdemont verfasserin aut Maria Serra-Blasco verfasserin aut Narcís Cardoner verfasserin aut Maria J. Portella verfasserin aut In BMC Psychiatry BMC, 2003 19(2019), 1, Seite 8 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/article/75541a74e9bb40dc8d292240a222a5a4 kostenfrei http://link.springer.com/article/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
allfields_unstemmed	10.1186/s12888-019-2117-4 doi (DE-627)DOAJ032985010 (DE-599)DOAJ75541a74e9bb40dc8d292240a222a5a4 DE-627 ger DE-627 rakwb eng RC435-571 Muriel Vicent-Gil verfasserin aut Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018. Cognitive remediation Depression Functional remediation Computerized cognitive training Clinical trial Psychiatry Beatriz Raventós verfasserin aut Eduardo D. Marín-Martínez verfasserin aut Sara González-Simarro verfasserin aut Anabel Martínez-Arán verfasserin aut Caterina del Mar Bonnin verfasserin aut Joan Trujols verfasserin aut Josefina Pérez-Blanco verfasserin aut Javier de Diego-Adeliño verfasserin aut Dolors Puigdemont verfasserin aut Maria Serra-Blasco verfasserin aut Narcís Cardoner verfasserin aut Maria J. Portella verfasserin aut In BMC Psychiatry BMC, 2003 19(2019), 1, Seite 8 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/article/75541a74e9bb40dc8d292240a222a5a4 kostenfrei http://link.springer.com/article/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
allfieldsGer	10.1186/s12888-019-2117-4 doi (DE-627)DOAJ032985010 (DE-599)DOAJ75541a74e9bb40dc8d292240a222a5a4 DE-627 ger DE-627 rakwb eng RC435-571 Muriel Vicent-Gil verfasserin aut Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018. Cognitive remediation Depression Functional remediation Computerized cognitive training Clinical trial Psychiatry Beatriz Raventós verfasserin aut Eduardo D. Marín-Martínez verfasserin aut Sara González-Simarro verfasserin aut Anabel Martínez-Arán verfasserin aut Caterina del Mar Bonnin verfasserin aut Joan Trujols verfasserin aut Josefina Pérez-Blanco verfasserin aut Javier de Diego-Adeliño verfasserin aut Dolors Puigdemont verfasserin aut Maria Serra-Blasco verfasserin aut Narcís Cardoner verfasserin aut Maria J. Portella verfasserin aut In BMC Psychiatry BMC, 2003 19(2019), 1, Seite 8 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/article/75541a74e9bb40dc8d292240a222a5a4 kostenfrei http://link.springer.com/article/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
allfieldsSound	10.1186/s12888-019-2117-4 doi (DE-627)DOAJ032985010 (DE-599)DOAJ75541a74e9bb40dc8d292240a222a5a4 DE-627 ger DE-627 rakwb eng RC435-571 Muriel Vicent-Gil verfasserin aut Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018. Cognitive remediation Depression Functional remediation Computerized cognitive training Clinical trial Psychiatry Beatriz Raventós verfasserin aut Eduardo D. Marín-Martínez verfasserin aut Sara González-Simarro verfasserin aut Anabel Martínez-Arán verfasserin aut Caterina del Mar Bonnin verfasserin aut Joan Trujols verfasserin aut Josefina Pérez-Blanco verfasserin aut Javier de Diego-Adeliño verfasserin aut Dolors Puigdemont verfasserin aut Maria Serra-Blasco verfasserin aut Narcís Cardoner verfasserin aut Maria J. Portella verfasserin aut In BMC Psychiatry BMC, 2003 19(2019), 1, Seite 8 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/article/75541a74e9bb40dc8d292240a222a5a4 kostenfrei http://link.springer.com/article/10.1186/s12888-019-2117-4 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
language	English
source	In BMC Psychiatry 19(2019), 1, Seite 8 volume:19 year:2019 number:1 pages:8
sourceStr	In BMC Psychiatry 19(2019), 1, Seite 8 volume:19 year:2019 number:1 pages:8
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cognitive remediation Depression Functional remediation Computerized cognitive training Clinical trial Psychiatry
isfreeaccess_bool	true
container_title	BMC Psychiatry
authorswithroles_txt_mv	Muriel Vicent-Gil @@aut@@ Beatriz Raventós @@aut@@ Eduardo D. Marín-Martínez @@aut@@ Sara González-Simarro @@aut@@ Anabel Martínez-Arán @@aut@@ Caterina del Mar Bonnin @@aut@@ Joan Trujols @@aut@@ Josefina Pérez-Blanco @@aut@@ Javier de Diego-Adeliño @@aut@@ Dolors Puigdemont @@aut@@ Maria Serra-Blasco @@aut@@ Narcís Cardoner @@aut@@ Maria J. Portella @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	331018799
id	DOAJ032985010
language_de	englisch
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This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. 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callnumber-first	R - Medicine
author	Muriel Vicent-Gil
spellingShingle	Muriel Vicent-Gil misc RC435-571 misc Cognitive remediation misc Depression misc Functional remediation misc Computerized cognitive training misc Clinical trial misc Psychiatry Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
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topic_title	RC435-571 Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial Cognitive remediation Depression Functional remediation Computerized cognitive training Clinical trial
topic	misc RC435-571 misc Cognitive remediation misc Depression misc Functional remediation misc Computerized cognitive training misc Clinical trial misc Psychiatry
topic_unstemmed	misc RC435-571 misc Cognitive remediation misc Depression misc Functional remediation misc Computerized cognitive training misc Clinical trial misc Psychiatry
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title	Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
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title_full	Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
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author_browse	Muriel Vicent-Gil Beatriz Raventós Eduardo D. Marín-Martínez Sara González-Simarro Anabel Martínez-Arán Caterina del Mar Bonnin Joan Trujols Josefina Pérez-Blanco Javier de Diego-Adeliño Dolors Puigdemont Maria Serra-Blasco Narcís Cardoner Maria J. Portella
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title_sort	testing the efficacy of integral cognitive remediation (increm) in major depressive disorder: study protocol for a randomized clinical trial
callnumber	RC435-571
title_auth	Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
abstract	Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018.
abstractGer	Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018.
abstract_unstemmed	Abstract Background Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration Clinical Trials NCT03624621. Date registered 10th of August 2018 and last updated 24th August 2018.
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title_short	Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
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Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial

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