rRNA methyltransferases and their role in resistance to antibiotics

Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and folding. Methylation of G1405 or A1408 nucleotides...
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Autor*in:	Morić Ivana [verfasserIn] Savić Miloje [verfasserIn] Ilić-Tomić Tatjana [verfasserIn] Vojnović Sandra [verfasserIn] Bajkić Sanja [verfasserIn] Vasiljević Branka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	aminoglycosides methyltransferases resistance ribosome

Übergeordnetes Werk:	In: Journal of Medical Biochemistry - Society of Medical Biochemists of Serbia, Belgrade, 2008, 29(2010), 3, Seite 165-174
Übergeordnetes Werk:	volume:29 ; year:2010 ; number:3 ; pages:165-174

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ033016127

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spelling	(DE-627)DOAJ033016127 (DE-599)DOAJ8f959ced14dc422b904dbd3e9c1d7ce7 DE-627 ger DE-627 rakwb eng QD415-436 Morić Ivana verfasserin aut rRNA methyltransferases and their role in resistance to antibiotics 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and folding. Methylation of G1405 or A1408 nucleotides of 16S rRNA in aminoglycoside-producing microorganisms confers the resistance to their own toxic product(s). This mechanism of resistance has been considered as unique to antibiotics producers until recently. Since 2003, methylation of 16S rRNA as a mechanism of resistance is increasingly emerging in pathogenic bacteria. This represents a major threat towards the usefulness of aminoglycosides in the clinical practice. A potential solution to the problem involves the design of novel compounds that would act against new ribosomal targets. The second approach to the issue includes the development of resistance MTases' inhibitors, with the idea to prevent them from modifying the bacterial rRNA, and thus reinstate the therapeutic power of existing aminoglycosides. As the latter approach has considerable potential, it is obvious that fundamental research related to protein expression, in-depth understanding of the mechanism of action and resolving a tertiary structure of 16S rRNAs MTases are prerequisites for application in medicine. aminoglycosides methyltransferases resistance ribosome Biochemistry Savić Miloje verfasserin aut Ilić-Tomić Tatjana verfasserin aut Vojnović Sandra verfasserin aut Bajkić Sanja verfasserin aut Vasiljević Branka verfasserin aut In Journal of Medical Biochemistry Society of Medical Biochemists of Serbia, Belgrade, 2008 29(2010), 3, Seite 165-174 (DE-627)557575117 (DE-600)2405112-3 14528266 nnns volume:29 year:2010 number:3 pages:165-174 https://doaj.org/article/8f959ced14dc422b904dbd3e9c1d7ce7 kostenfrei https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2010/1452-82581003165M.pdf kostenfrei https://doaj.org/toc/1452-8258 Journal toc kostenfrei https://doaj.org/toc/1452-8266 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 AR 29 2010 3 165-174
allfields_unstemmed	(DE-627)DOAJ033016127 (DE-599)DOAJ8f959ced14dc422b904dbd3e9c1d7ce7 DE-627 ger DE-627 rakwb eng QD415-436 Morić Ivana verfasserin aut rRNA methyltransferases and their role in resistance to antibiotics 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and folding. Methylation of G1405 or A1408 nucleotides of 16S rRNA in aminoglycoside-producing microorganisms confers the resistance to their own toxic product(s). This mechanism of resistance has been considered as unique to antibiotics producers until recently. Since 2003, methylation of 16S rRNA as a mechanism of resistance is increasingly emerging in pathogenic bacteria. This represents a major threat towards the usefulness of aminoglycosides in the clinical practice. A potential solution to the problem involves the design of novel compounds that would act against new ribosomal targets. The second approach to the issue includes the development of resistance MTases' inhibitors, with the idea to prevent them from modifying the bacterial rRNA, and thus reinstate the therapeutic power of existing aminoglycosides. As the latter approach has considerable potential, it is obvious that fundamental research related to protein expression, in-depth understanding of the mechanism of action and resolving a tertiary structure of 16S rRNAs MTases are prerequisites for application in medicine. aminoglycosides methyltransferases resistance ribosome Biochemistry Savić Miloje verfasserin aut Ilić-Tomić Tatjana verfasserin aut Vojnović Sandra verfasserin aut Bajkić Sanja verfasserin aut Vasiljević Branka verfasserin aut In Journal of Medical Biochemistry Society of Medical Biochemists of Serbia, Belgrade, 2008 29(2010), 3, Seite 165-174 (DE-627)557575117 (DE-600)2405112-3 14528266 nnns volume:29 year:2010 number:3 pages:165-174 https://doaj.org/article/8f959ced14dc422b904dbd3e9c1d7ce7 kostenfrei https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2010/1452-82581003165M.pdf kostenfrei https://doaj.org/toc/1452-8258 Journal toc kostenfrei https://doaj.org/toc/1452-8266 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 AR 29 2010 3 165-174
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author_browse	Morić Ivana Savić Miloje Ilić-Tomić Tatjana Vojnović Sandra Bajkić Sanja Vasiljević Branka
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title_sort	rrna methyltransferases and their role in resistance to antibiotics
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title_auth	rRNA methyltransferases and their role in resistance to antibiotics
abstract	Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and folding. Methylation of G1405 or A1408 nucleotides of 16S rRNA in aminoglycoside-producing microorganisms confers the resistance to their own toxic product(s). This mechanism of resistance has been considered as unique to antibiotics producers until recently. Since 2003, methylation of 16S rRNA as a mechanism of resistance is increasingly emerging in pathogenic bacteria. This represents a major threat towards the usefulness of aminoglycosides in the clinical practice. A potential solution to the problem involves the design of novel compounds that would act against new ribosomal targets. The second approach to the issue includes the development of resistance MTases' inhibitors, with the idea to prevent them from modifying the bacterial rRNA, and thus reinstate the therapeutic power of existing aminoglycosides. As the latter approach has considerable potential, it is obvious that fundamental research related to protein expression, in-depth understanding of the mechanism of action and resolving a tertiary structure of 16S rRNAs MTases are prerequisites for application in medicine.
abstractGer	Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and folding. Methylation of G1405 or A1408 nucleotides of 16S rRNA in aminoglycoside-producing microorganisms confers the resistance to their own toxic product(s). This mechanism of resistance has been considered as unique to antibiotics producers until recently. Since 2003, methylation of 16S rRNA as a mechanism of resistance is increasingly emerging in pathogenic bacteria. This represents a major threat towards the usefulness of aminoglycosides in the clinical practice. A potential solution to the problem involves the design of novel compounds that would act against new ribosomal targets. The second approach to the issue includes the development of resistance MTases' inhibitors, with the idea to prevent them from modifying the bacterial rRNA, and thus reinstate the therapeutic power of existing aminoglycosides. As the latter approach has considerable potential, it is obvious that fundamental research related to protein expression, in-depth understanding of the mechanism of action and resolving a tertiary structure of 16S rRNAs MTases are prerequisites for application in medicine.
abstract_unstemmed	Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and folding. Methylation of G1405 or A1408 nucleotides of 16S rRNA in aminoglycoside-producing microorganisms confers the resistance to their own toxic product(s). This mechanism of resistance has been considered as unique to antibiotics producers until recently. Since 2003, methylation of 16S rRNA as a mechanism of resistance is increasingly emerging in pathogenic bacteria. This represents a major threat towards the usefulness of aminoglycosides in the clinical practice. A potential solution to the problem involves the design of novel compounds that would act against new ribosomal targets. The second approach to the issue includes the development of resistance MTases' inhibitors, with the idea to prevent them from modifying the bacterial rRNA, and thus reinstate the therapeutic power of existing aminoglycosides. As the latter approach has considerable potential, it is obvious that fundamental research related to protein expression, in-depth understanding of the mechanism of action and resolving a tertiary structure of 16S rRNAs MTases are prerequisites for application in medicine.
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title_short	rRNA methyltransferases and their role in resistance to antibiotics
url	https://doaj.org/article/8f959ced14dc422b904dbd3e9c1d7ce7 https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2010/1452-82581003165M.pdf https://doaj.org/toc/1452-8258 https://doaj.org/toc/1452-8266
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author2	Savić Miloje Ilić-Tomić Tatjana Vojnović Sandra Bajkić Sanja Vasiljević Branka
author2Str	Savić Miloje Ilić-Tomić Tatjana Vojnović Sandra Bajkić Sanja Vasiljević Branka
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up_date	2024-07-03T15:21:56.210Z
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