lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter
Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-asso...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Song Fan [verfasserIn] Tian Tian [verfasserIn] Xiaobin Lv [verfasserIn] Xinyuan Lei [verfasserIn] Zhaohui Yang [verfasserIn] Mo Liu [verfasserIn] Faya Liang [verfasserIn] Shunrong Li [verfasserIn] Xiaofeng Lin [verfasserIn] Zhaoyu Lin [verfasserIn] Shule Xie [verfasserIn] Bowen Li [verfasserIn] Weixiong Chen [verfasserIn] Guokai Pan [verfasserIn] Xinyu Lin [verfasserIn] Zhanpeng Ou [verfasserIn] Yin Zhang [verfasserIn] Yu Peng [verfasserIn] Liping Xiao [verfasserIn] Lizao Zhang [verfasserIn] Sheng Sun [verfasserIn] Hanqing Zhang [verfasserIn] Sigeng Lin [verfasserIn] Qunxing Li [verfasserIn] Binghui Zeng [verfasserIn] Filippos Kontos [verfasserIn] Yi Ruan [verfasserIn] Soldano Ferrone [verfasserIn] Dechen Lin [verfasserIn] Bakhos A. Tannous [verfasserIn] Jinsong Li [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
In: iScience - Elsevier, 2019, 23(2020), 2, Seite - |
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| Übergeordnetes Werk: |
volume:23 ; year:2020 ; number:2 ; pages:- |
| Links: |
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| DOI / URN: |
10.1016/j.isci.2020.100835 |
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| Katalog-ID: |
DOAJ033051712 |
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| 520 | |a Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer | ||
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| 700 | 0 | |a Zhanpeng Ou |e verfasserin |4 aut | |
| 700 | 0 | |a Yin Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Yu Peng |e verfasserin |4 aut | |
| 700 | 0 | |a Liping Xiao |e verfasserin |4 aut | |
| 700 | 0 | |a Lizao Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Sheng Sun |e verfasserin |4 aut | |
| 700 | 0 | |a Hanqing Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Sigeng Lin |e verfasserin |4 aut | |
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| 700 | 0 | |a Bakhos A. Tannous |e verfasserin |4 aut | |
| 700 | 0 | |a Jinsong Li |e verfasserin |4 aut | |
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10.1016/j.isci.2020.100835 doi (DE-627)DOAJ033051712 (DE-599)DOAJ2f1c03db9f8f4863ace0102cda649af1 DE-627 ger DE-627 rakwb eng Song Fan verfasserin aut lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer Science Q Tian Tian verfasserin aut Xiaobin Lv verfasserin aut Xinyuan Lei verfasserin aut Zhaohui Yang verfasserin aut Mo Liu verfasserin aut Faya Liang verfasserin aut Shunrong Li verfasserin aut Xiaofeng Lin verfasserin aut Zhaoyu Lin verfasserin aut Shule Xie verfasserin aut Bowen Li verfasserin aut Weixiong Chen verfasserin aut Guokai Pan verfasserin aut Xinyu Lin verfasserin aut Zhanpeng Ou verfasserin aut Yin Zhang verfasserin aut Yu Peng verfasserin aut Liping Xiao verfasserin aut Lizao Zhang verfasserin aut Sheng Sun verfasserin aut Hanqing Zhang verfasserin aut Sigeng Lin verfasserin aut Qunxing Li verfasserin aut Binghui Zeng verfasserin aut Filippos Kontos verfasserin aut Yi Ruan verfasserin aut Soldano Ferrone verfasserin aut Dechen Lin verfasserin aut Bakhos A. Tannous verfasserin aut Jinsong Li verfasserin aut In iScience Elsevier, 2019 23(2020), 2, Seite - (DE-627)1019532106 25890042 nnns volume:23 year:2020 number:2 pages:- https://doi.org/10.1016/j.isci.2020.100835 kostenfrei https://doaj.org/article/2f1c03db9f8f4863ace0102cda649af1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004220300183 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 2 - |
| spelling |
10.1016/j.isci.2020.100835 doi (DE-627)DOAJ033051712 (DE-599)DOAJ2f1c03db9f8f4863ace0102cda649af1 DE-627 ger DE-627 rakwb eng Song Fan verfasserin aut lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer Science Q Tian Tian verfasserin aut Xiaobin Lv verfasserin aut Xinyuan Lei verfasserin aut Zhaohui Yang verfasserin aut Mo Liu verfasserin aut Faya Liang verfasserin aut Shunrong Li verfasserin aut Xiaofeng Lin verfasserin aut Zhaoyu Lin verfasserin aut Shule Xie verfasserin aut Bowen Li verfasserin aut Weixiong Chen verfasserin aut Guokai Pan verfasserin aut Xinyu Lin verfasserin aut Zhanpeng Ou verfasserin aut Yin Zhang verfasserin aut Yu Peng verfasserin aut Liping Xiao verfasserin aut Lizao Zhang verfasserin aut Sheng Sun verfasserin aut Hanqing Zhang verfasserin aut Sigeng Lin verfasserin aut Qunxing Li verfasserin aut Binghui Zeng verfasserin aut Filippos Kontos verfasserin aut Yi Ruan verfasserin aut Soldano Ferrone verfasserin aut Dechen Lin verfasserin aut Bakhos A. Tannous verfasserin aut Jinsong Li verfasserin aut In iScience Elsevier, 2019 23(2020), 2, Seite - (DE-627)1019532106 25890042 nnns volume:23 year:2020 number:2 pages:- https://doi.org/10.1016/j.isci.2020.100835 kostenfrei https://doaj.org/article/2f1c03db9f8f4863ace0102cda649af1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004220300183 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 2 - |
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10.1016/j.isci.2020.100835 doi (DE-627)DOAJ033051712 (DE-599)DOAJ2f1c03db9f8f4863ace0102cda649af1 DE-627 ger DE-627 rakwb eng Song Fan verfasserin aut lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer Science Q Tian Tian verfasserin aut Xiaobin Lv verfasserin aut Xinyuan Lei verfasserin aut Zhaohui Yang verfasserin aut Mo Liu verfasserin aut Faya Liang verfasserin aut Shunrong Li verfasserin aut Xiaofeng Lin verfasserin aut Zhaoyu Lin verfasserin aut Shule Xie verfasserin aut Bowen Li verfasserin aut Weixiong Chen verfasserin aut Guokai Pan verfasserin aut Xinyu Lin verfasserin aut Zhanpeng Ou verfasserin aut Yin Zhang verfasserin aut Yu Peng verfasserin aut Liping Xiao verfasserin aut Lizao Zhang verfasserin aut Sheng Sun verfasserin aut Hanqing Zhang verfasserin aut Sigeng Lin verfasserin aut Qunxing Li verfasserin aut Binghui Zeng verfasserin aut Filippos Kontos verfasserin aut Yi Ruan verfasserin aut Soldano Ferrone verfasserin aut Dechen Lin verfasserin aut Bakhos A. Tannous verfasserin aut Jinsong Li verfasserin aut In iScience Elsevier, 2019 23(2020), 2, Seite - (DE-627)1019532106 25890042 nnns volume:23 year:2020 number:2 pages:- https://doi.org/10.1016/j.isci.2020.100835 kostenfrei https://doaj.org/article/2f1c03db9f8f4863ace0102cda649af1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004220300183 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 2 - |
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10.1016/j.isci.2020.100835 doi (DE-627)DOAJ033051712 (DE-599)DOAJ2f1c03db9f8f4863ace0102cda649af1 DE-627 ger DE-627 rakwb eng Song Fan verfasserin aut lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer Science Q Tian Tian verfasserin aut Xiaobin Lv verfasserin aut Xinyuan Lei verfasserin aut Zhaohui Yang verfasserin aut Mo Liu verfasserin aut Faya Liang verfasserin aut Shunrong Li verfasserin aut Xiaofeng Lin verfasserin aut Zhaoyu Lin verfasserin aut Shule Xie verfasserin aut Bowen Li verfasserin aut Weixiong Chen verfasserin aut Guokai Pan verfasserin aut Xinyu Lin verfasserin aut Zhanpeng Ou verfasserin aut Yin Zhang verfasserin aut Yu Peng verfasserin aut Liping Xiao verfasserin aut Lizao Zhang verfasserin aut Sheng Sun verfasserin aut Hanqing Zhang verfasserin aut Sigeng Lin verfasserin aut Qunxing Li verfasserin aut Binghui Zeng verfasserin aut Filippos Kontos verfasserin aut Yi Ruan verfasserin aut Soldano Ferrone verfasserin aut Dechen Lin verfasserin aut Bakhos A. Tannous verfasserin aut Jinsong Li verfasserin aut In iScience Elsevier, 2019 23(2020), 2, Seite - (DE-627)1019532106 25890042 nnns volume:23 year:2020 number:2 pages:- https://doi.org/10.1016/j.isci.2020.100835 kostenfrei https://doaj.org/article/2f1c03db9f8f4863ace0102cda649af1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004220300183 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 2 - |
| allfieldsSound |
10.1016/j.isci.2020.100835 doi (DE-627)DOAJ033051712 (DE-599)DOAJ2f1c03db9f8f4863ace0102cda649af1 DE-627 ger DE-627 rakwb eng Song Fan verfasserin aut lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer Science Q Tian Tian verfasserin aut Xiaobin Lv verfasserin aut Xinyuan Lei verfasserin aut Zhaohui Yang verfasserin aut Mo Liu verfasserin aut Faya Liang verfasserin aut Shunrong Li verfasserin aut Xiaofeng Lin verfasserin aut Zhaoyu Lin verfasserin aut Shule Xie verfasserin aut Bowen Li verfasserin aut Weixiong Chen verfasserin aut Guokai Pan verfasserin aut Xinyu Lin verfasserin aut Zhanpeng Ou verfasserin aut Yin Zhang verfasserin aut Yu Peng verfasserin aut Liping Xiao verfasserin aut Lizao Zhang verfasserin aut Sheng Sun verfasserin aut Hanqing Zhang verfasserin aut Sigeng Lin verfasserin aut Qunxing Li verfasserin aut Binghui Zeng verfasserin aut Filippos Kontos verfasserin aut Yi Ruan verfasserin aut Soldano Ferrone verfasserin aut Dechen Lin verfasserin aut Bakhos A. Tannous verfasserin aut Jinsong Li verfasserin aut In iScience Elsevier, 2019 23(2020), 2, Seite - (DE-627)1019532106 25890042 nnns volume:23 year:2020 number:2 pages:- https://doi.org/10.1016/j.isci.2020.100835 kostenfrei https://doaj.org/article/2f1c03db9f8f4863ace0102cda649af1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004220300183 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 2 - |
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Song Fan @@aut@@ Tian Tian @@aut@@ Xiaobin Lv @@aut@@ Xinyuan Lei @@aut@@ Zhaohui Yang @@aut@@ Mo Liu @@aut@@ Faya Liang @@aut@@ Shunrong Li @@aut@@ Xiaofeng Lin @@aut@@ Zhaoyu Lin @@aut@@ Shule Xie @@aut@@ Bowen Li @@aut@@ Weixiong Chen @@aut@@ Guokai Pan @@aut@@ Xinyu Lin @@aut@@ Zhanpeng Ou @@aut@@ Yin Zhang @@aut@@ Yu Peng @@aut@@ Liping Xiao @@aut@@ Lizao Zhang @@aut@@ Sheng Sun @@aut@@ Hanqing Zhang @@aut@@ Sigeng Lin @@aut@@ Qunxing Li @@aut@@ Binghui Zeng @@aut@@ Filippos Kontos @@aut@@ Yi Ruan @@aut@@ Soldano Ferrone @@aut@@ Dechen Lin @@aut@@ Bakhos A. Tannous @@aut@@ Jinsong Li @@aut@@ |
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lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter |
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Song Fan Tian Tian Xiaobin Lv Xinyuan Lei Zhaohui Yang Mo Liu Faya Liang Shunrong Li Xiaofeng Lin Zhaoyu Lin Shule Xie Bowen Li Weixiong Chen Guokai Pan Xinyu Lin Zhanpeng Ou Yin Zhang Yu Peng Liping Xiao Lizao Zhang Sheng Sun Hanqing Zhang Sigeng Lin Qunxing Li Binghui Zeng Filippos Kontos Yi Ruan Soldano Ferrone Dechen Lin Bakhos A. Tannous Jinsong Li |
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lncrna cisal inhibits brca1 transcription by forming a tertiary structure at its promoter |
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lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter |
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Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer |
| abstractGer |
Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer |
| abstract_unstemmed |
Summary: Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. : Biological Sciences; Molecular Biology; Cell Biology; Cancer Subject Areas: Biological Sciences, Molecular Biology, Cell Biology, Cancer |
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lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter |
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Tian Tian Xiaobin Lv Xinyuan Lei Zhaohui Yang Mo Liu Faya Liang Shunrong Li Xiaofeng Lin Zhaoyu Lin Shule Xie Bowen Li Weixiong Chen Guokai Pan Xinyu Lin Zhanpeng Ou Yin Zhang Yu Peng Liping Xiao Lizao Zhang Sheng Sun Hanqing Zhang Sigeng Lin Qunxing Li Binghui Zeng Filippos Kontos Yi Ruan Soldano Ferrone Dechen Lin Bakhos A. Tannous Jinsong Li |
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Tian Tian Xiaobin Lv Xinyuan Lei Zhaohui Yang Mo Liu Faya Liang Shunrong Li Xiaofeng Lin Zhaoyu Lin Shule Xie Bowen Li Weixiong Chen Guokai Pan Xinyu Lin Zhanpeng Ou Yin Zhang Yu Peng Liping Xiao Lizao Zhang Sheng Sun Hanqing Zhang Sigeng Lin Qunxing Li Binghui Zeng Filippos Kontos Yi Ruan Soldano Ferrone Dechen Lin Bakhos A. Tannous Jinsong Li |
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