Insight into the WNT system and its drug related response

The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic...
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Autor*in:	S. Tamanini [verfasserIn] L. Idolazzi [verfasserIn] D. Gatti [verfasserIn] O. Viapiana [verfasserIn] A. Fassio [verfasserIn] M. Rossini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Italienisch

Erschienen:	2013

Schlagwörter:	WNT, DKK1, Sclerostin, Bisphosphonate.

Übergeordnetes Werk:	In: Reumatismo - PAGEPress Publications, 2012, 65(2013), 5, Seite 219-230
Übergeordnetes Werk:	volume:65 ; year:2013 ; number:5 ; pages:219-230

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4081/reumatismo.2013.219

Katalog-ID:	DOAJ033071705

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allfieldsGer	10.4081/reumatismo.2013.219 doi (DE-627)DOAJ033071705 (DE-599)DOAJcc9aa5a57b744e8e814be3affb1a06ce DE-627 ger DE-627 rakwb eng ita RC31-1245 S. Tamanini verfasserin aut Insight into the WNT system and its drug related response 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic processes. The WNT system acts on all cellular lines involved in bone resorption and formation. WNT pathway can mainly be triggered by two different signalling cascades. The first is well known and is the so-called WNT-beta catenin system (or the canonical pathway), the second is known as the non canonical WNT pathway. WNT proteins form a superfamily of secreted glycoproteins. The association with surface receptors, called <em<Frizzled</em<, that are members of the G protein-coupled receptors superfamily and co receptors like low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) complete the WNT system. LRP5/6 show high affinity for WNT antagonists that modulate the activity of this pathway: DKK1 and sclerostin (SCL), that play a crucial role in modulating the WNT system. The WNT-pathway and in particular its antagonists SCL and DKK1 seems to play a key role in the regulation of bone remodeling during treatment with bone active agents such as bisphosphonates, but not only. Their effects become relevant especially in the course of long-term treatments. WNT, DKK1, Sclerostin, Bisphosphonate. Medicine R Internal medicine L. Idolazzi verfasserin aut D. Gatti verfasserin aut O. Viapiana verfasserin aut A. Fassio verfasserin aut M. Rossini verfasserin aut In Reumatismo PAGEPress Publications, 2012 65(2013), 5, Seite 219-230 (DE-627)355986361 (DE-600)2091202-X 22402683 nnns volume:65 year:2013 number:5 pages:219-230 https://doi.org/10.4081/reumatismo.2013.219 kostenfrei https://doaj.org/article/cc9aa5a57b744e8e814be3affb1a06ce kostenfrei http://www.reumatismo.org/index.php/reuma/article/view/683 kostenfrei https://doaj.org/toc/0048-7449 Journal toc kostenfrei https://doaj.org/toc/2240-2683 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2013 5 219-230
allfieldsSound	10.4081/reumatismo.2013.219 doi (DE-627)DOAJ033071705 (DE-599)DOAJcc9aa5a57b744e8e814be3affb1a06ce DE-627 ger DE-627 rakwb eng ita RC31-1245 S. Tamanini verfasserin aut Insight into the WNT system and its drug related response 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic processes. The WNT system acts on all cellular lines involved in bone resorption and formation. WNT pathway can mainly be triggered by two different signalling cascades. The first is well known and is the so-called WNT-beta catenin system (or the canonical pathway), the second is known as the non canonical WNT pathway. WNT proteins form a superfamily of secreted glycoproteins. The association with surface receptors, called <em<Frizzled</em<, that are members of the G protein-coupled receptors superfamily and co receptors like low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) complete the WNT system. LRP5/6 show high affinity for WNT antagonists that modulate the activity of this pathway: DKK1 and sclerostin (SCL), that play a crucial role in modulating the WNT system. The WNT-pathway and in particular its antagonists SCL and DKK1 seems to play a key role in the regulation of bone remodeling during treatment with bone active agents such as bisphosphonates, but not only. Their effects become relevant especially in the course of long-term treatments. WNT, DKK1, Sclerostin, Bisphosphonate. Medicine R Internal medicine L. Idolazzi verfasserin aut D. Gatti verfasserin aut O. Viapiana verfasserin aut A. Fassio verfasserin aut M. Rossini verfasserin aut In Reumatismo PAGEPress Publications, 2012 65(2013), 5, Seite 219-230 (DE-627)355986361 (DE-600)2091202-X 22402683 nnns volume:65 year:2013 number:5 pages:219-230 https://doi.org/10.4081/reumatismo.2013.219 kostenfrei https://doaj.org/article/cc9aa5a57b744e8e814be3affb1a06ce kostenfrei http://www.reumatismo.org/index.php/reuma/article/view/683 kostenfrei https://doaj.org/toc/0048-7449 Journal toc kostenfrei https://doaj.org/toc/2240-2683 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2013 5 219-230
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title	Insight into the WNT system and its drug related response
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title_full	Insight into the WNT system and its drug related response
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title_sort	insight into the wnt system and its drug related response
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title_auth	Insight into the WNT system and its drug related response
abstract	The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic processes. The WNT system acts on all cellular lines involved in bone resorption and formation. WNT pathway can mainly be triggered by two different signalling cascades. The first is well known and is the so-called WNT-beta catenin system (or the canonical pathway), the second is known as the non canonical WNT pathway. WNT proteins form a superfamily of secreted glycoproteins. The association with surface receptors, called <em<Frizzled</em<, that are members of the G protein-coupled receptors superfamily and co receptors like low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) complete the WNT system. LRP5/6 show high affinity for WNT antagonists that modulate the activity of this pathway: DKK1 and sclerostin (SCL), that play a crucial role in modulating the WNT system. The WNT-pathway and in particular its antagonists SCL and DKK1 seems to play a key role in the regulation of bone remodeling during treatment with bone active agents such as bisphosphonates, but not only. Their effects become relevant especially in the course of long-term treatments.
abstractGer	The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic processes. The WNT system acts on all cellular lines involved in bone resorption and formation. WNT pathway can mainly be triggered by two different signalling cascades. The first is well known and is the so-called WNT-beta catenin system (or the canonical pathway), the second is known as the non canonical WNT pathway. WNT proteins form a superfamily of secreted glycoproteins. The association with surface receptors, called <em<Frizzled</em<, that are members of the G protein-coupled receptors superfamily and co receptors like low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) complete the WNT system. LRP5/6 show high affinity for WNT antagonists that modulate the activity of this pathway: DKK1 and sclerostin (SCL), that play a crucial role in modulating the WNT system. The WNT-pathway and in particular its antagonists SCL and DKK1 seems to play a key role in the regulation of bone remodeling during treatment with bone active agents such as bisphosphonates, but not only. Their effects become relevant especially in the course of long-term treatments.
abstract_unstemmed	The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic processes. The WNT system acts on all cellular lines involved in bone resorption and formation. WNT pathway can mainly be triggered by two different signalling cascades. The first is well known and is the so-called WNT-beta catenin system (or the canonical pathway), the second is known as the non canonical WNT pathway. WNT proteins form a superfamily of secreted glycoproteins. The association with surface receptors, called <em<Frizzled</em<, that are members of the G protein-coupled receptors superfamily and co receptors like low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) complete the WNT system. LRP5/6 show high affinity for WNT antagonists that modulate the activity of this pathway: DKK1 and sclerostin (SCL), that play a crucial role in modulating the WNT system. The WNT-pathway and in particular its antagonists SCL and DKK1 seems to play a key role in the regulation of bone remodeling during treatment with bone active agents such as bisphosphonates, but not only. Their effects become relevant especially in the course of long-term treatments.
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title_short	Insight into the WNT system and its drug related response
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