Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.

Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDB...
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Autor*in:	Eugenia Lo [verfasserIn] Jessica B Hostetler [verfasserIn] Delenasaw Yewhalaw [verfasserIn] Richard D Pearson [verfasserIn] Muzamil M A Hamid [verfasserIn] Karthigayan Gunalan [verfasserIn] Daniel Kepple [verfasserIn] Anthony Ford [verfasserIn] Daniel A Janies [verfasserIn] Julian C Rayner [verfasserIn] Louis H Miller [verfasserIn] Guiyun Yan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: PLoS Neglected Tropical Diseases - Public Library of Science (PLoS), 2008, 13(2019), 9, p e0007222
Übergeordnetes Werk:	volume:13 ; year:2019 ; number:9, p e0007222

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.pntd.0007222

Katalog-ID:	DOAJ033278350

Internformat


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520			\|a Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly.
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allfields	10.1371/journal.pntd.0007222 doi (DE-627)DOAJ033278350 (DE-599)DOAJ2e2523b8d99d44728473b71cf25d0c74 DE-627 ger DE-627 rakwb eng RC955-962 RA1-1270 Eugenia Lo verfasserin aut Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly. Arctic medicine. Tropical medicine Public aspects of medicine Jessica B Hostetler verfasserin aut Delenasaw Yewhalaw verfasserin aut Richard D Pearson verfasserin aut Muzamil M A Hamid verfasserin aut Karthigayan Gunalan verfasserin aut Daniel Kepple verfasserin aut Anthony Ford verfasserin aut Daniel A Janies verfasserin aut Julian C Rayner verfasserin aut Louis H Miller verfasserin aut Guiyun Yan verfasserin aut In PLoS Neglected Tropical Diseases Public Library of Science (PLoS), 2008 13(2019), 9, p e0007222 (DE-627)568915356 (DE-600)2429704-5 19352735 nnns volume:13 year:2019 number:9, p e0007222 https://doi.org/10.1371/journal.pntd.0007222 kostenfrei https://doaj.org/article/2e2523b8d99d44728473b71cf25d0c74 kostenfrei http://europepmc.org/articles/PMC6756552?pdf=render kostenfrei https://doaj.org/toc/1935-2727 Journal toc kostenfrei https://doaj.org/toc/1935-2735 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019 9, p e0007222
spelling	10.1371/journal.pntd.0007222 doi (DE-627)DOAJ033278350 (DE-599)DOAJ2e2523b8d99d44728473b71cf25d0c74 DE-627 ger DE-627 rakwb eng RC955-962 RA1-1270 Eugenia Lo verfasserin aut Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly. Arctic medicine. Tropical medicine Public aspects of medicine Jessica B Hostetler verfasserin aut Delenasaw Yewhalaw verfasserin aut Richard D Pearson verfasserin aut Muzamil M A Hamid verfasserin aut Karthigayan Gunalan verfasserin aut Daniel Kepple verfasserin aut Anthony Ford verfasserin aut Daniel A Janies verfasserin aut Julian C Rayner verfasserin aut Louis H Miller verfasserin aut Guiyun Yan verfasserin aut In PLoS Neglected Tropical Diseases Public Library of Science (PLoS), 2008 13(2019), 9, p e0007222 (DE-627)568915356 (DE-600)2429704-5 19352735 nnns volume:13 year:2019 number:9, p e0007222 https://doi.org/10.1371/journal.pntd.0007222 kostenfrei https://doaj.org/article/2e2523b8d99d44728473b71cf25d0c74 kostenfrei http://europepmc.org/articles/PMC6756552?pdf=render kostenfrei https://doaj.org/toc/1935-2727 Journal toc kostenfrei https://doaj.org/toc/1935-2735 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019 9, p e0007222
allfields_unstemmed	10.1371/journal.pntd.0007222 doi (DE-627)DOAJ033278350 (DE-599)DOAJ2e2523b8d99d44728473b71cf25d0c74 DE-627 ger DE-627 rakwb eng RC955-962 RA1-1270 Eugenia Lo verfasserin aut Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly. Arctic medicine. Tropical medicine Public aspects of medicine Jessica B Hostetler verfasserin aut Delenasaw Yewhalaw verfasserin aut Richard D Pearson verfasserin aut Muzamil M A Hamid verfasserin aut Karthigayan Gunalan verfasserin aut Daniel Kepple verfasserin aut Anthony Ford verfasserin aut Daniel A Janies verfasserin aut Julian C Rayner verfasserin aut Louis H Miller verfasserin aut Guiyun Yan verfasserin aut In PLoS Neglected Tropical Diseases Public Library of Science (PLoS), 2008 13(2019), 9, p e0007222 (DE-627)568915356 (DE-600)2429704-5 19352735 nnns volume:13 year:2019 number:9, p e0007222 https://doi.org/10.1371/journal.pntd.0007222 kostenfrei https://doaj.org/article/2e2523b8d99d44728473b71cf25d0c74 kostenfrei http://europepmc.org/articles/PMC6756552?pdf=render kostenfrei https://doaj.org/toc/1935-2727 Journal toc kostenfrei https://doaj.org/toc/1935-2735 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019 9, p e0007222
allfieldsGer	10.1371/journal.pntd.0007222 doi (DE-627)DOAJ033278350 (DE-599)DOAJ2e2523b8d99d44728473b71cf25d0c74 DE-627 ger DE-627 rakwb eng RC955-962 RA1-1270 Eugenia Lo verfasserin aut Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly. Arctic medicine. Tropical medicine Public aspects of medicine Jessica B Hostetler verfasserin aut Delenasaw Yewhalaw verfasserin aut Richard D Pearson verfasserin aut Muzamil M A Hamid verfasserin aut Karthigayan Gunalan verfasserin aut Daniel Kepple verfasserin aut Anthony Ford verfasserin aut Daniel A Janies verfasserin aut Julian C Rayner verfasserin aut Louis H Miller verfasserin aut Guiyun Yan verfasserin aut In PLoS Neglected Tropical Diseases Public Library of Science (PLoS), 2008 13(2019), 9, p e0007222 (DE-627)568915356 (DE-600)2429704-5 19352735 nnns volume:13 year:2019 number:9, p e0007222 https://doi.org/10.1371/journal.pntd.0007222 kostenfrei https://doaj.org/article/2e2523b8d99d44728473b71cf25d0c74 kostenfrei http://europepmc.org/articles/PMC6756552?pdf=render kostenfrei https://doaj.org/toc/1935-2727 Journal toc kostenfrei https://doaj.org/toc/1935-2735 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019 9, p e0007222
allfieldsSound	10.1371/journal.pntd.0007222 doi (DE-627)DOAJ033278350 (DE-599)DOAJ2e2523b8d99d44728473b71cf25d0c74 DE-627 ger DE-627 rakwb eng RC955-962 RA1-1270 Eugenia Lo verfasserin aut Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly. Arctic medicine. Tropical medicine Public aspects of medicine Jessica B Hostetler verfasserin aut Delenasaw Yewhalaw verfasserin aut Richard D Pearson verfasserin aut Muzamil M A Hamid verfasserin aut Karthigayan Gunalan verfasserin aut Daniel Kepple verfasserin aut Anthony Ford verfasserin aut Daniel A Janies verfasserin aut Julian C Rayner verfasserin aut Louis H Miller verfasserin aut Guiyun Yan verfasserin aut In PLoS Neglected Tropical Diseases Public Library of Science (PLoS), 2008 13(2019), 9, p e0007222 (DE-627)568915356 (DE-600)2429704-5 19352735 nnns volume:13 year:2019 number:9, p e0007222 https://doi.org/10.1371/journal.pntd.0007222 kostenfrei https://doaj.org/article/2e2523b8d99d44728473b71cf25d0c74 kostenfrei http://europepmc.org/articles/PMC6756552?pdf=render kostenfrei https://doaj.org/toc/1935-2727 Journal toc kostenfrei https://doaj.org/toc/1935-2735 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019 9, p e0007222
language	English
source	In PLoS Neglected Tropical Diseases 13(2019), 9, p e0007222 volume:13 year:2019 number:9, p e0007222
sourceStr	In PLoS Neglected Tropical Diseases 13(2019), 9, p e0007222 volume:13 year:2019 number:9, p e0007222
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Arctic medicine. Tropical medicine Public aspects of medicine
isfreeaccess_bool	true
container_title	PLoS Neglected Tropical Diseases
authorswithroles_txt_mv	Eugenia Lo @@aut@@ Jessica B Hostetler @@aut@@ Delenasaw Yewhalaw @@aut@@ Richard D Pearson @@aut@@ Muzamil M A Hamid @@aut@@ Karthigayan Gunalan @@aut@@ Daniel Kepple @@aut@@ Anthony Ford @@aut@@ Daniel A Janies @@aut@@ Julian C Rayner @@aut@@ Louis H Miller @@aut@@ Guiyun Yan @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	568915356
id	DOAJ033278350
language_de	englisch
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callnumber-first	R - Medicine
author	Eugenia Lo
spellingShingle	Eugenia Lo misc RC955-962 misc RA1-1270 misc Arctic medicine. Tropical medicine misc Public aspects of medicine Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.
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topic_title	RC955-962 RA1-1270 Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
topic	misc RC955-962 misc RA1-1270 misc Arctic medicine. Tropical medicine misc Public aspects of medicine
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title	Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.
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title_full	Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
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author_browse	Eugenia Lo Jessica B Hostetler Delenasaw Yewhalaw Richard D Pearson Muzamil M A Hamid Karthigayan Gunalan Daniel Kepple Anthony Ford Daniel A Janies Julian C Rayner Louis H Miller Guiyun Yan
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title_sort	frequent expansion of plasmodium vivax duffy binding protein in ethiopia and its epidemiological significance
callnumber	RC955-962
title_auth	Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.
abstract	Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly.
abstractGer	Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly.
abstract_unstemmed	Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDBP multiplications, as well as its significance across broad samples are still unclear. We determined the prevalence and type of PvDBP duplications, as well as PvDBP copy number variation among 178 Ethiopian P. vivax isolates using a PCR-based diagnostic method, a novel quantitative real-time PCR assay and whole genome sequencing. For the 145 symptomatic samples, PvDBP duplications were detected in 95 isolates, of which 81 had the Cambodian and 14 Malagasy-type PvDBP duplications. PvDBP varied from 1 to <4 copies. Isolates with multiple PvDBP copies were found to be higher in symptomatic than asymptomatic infections. For the 33 asymptomatic samples, PvDBP was detected with two copies in two of the isolates, and both were the Cambodian-type PvDBP duplication. PvDBP copy number in Duffy-negative heterozygotes was not significantly different from that in Duffy-positives, providing no support for the hypothesis that increased copy number is a specific association with Duffy-negativity, although the number of Duffy-negatives was small and further sampling is required to test this association thoroughly.
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container_issue	9, p e0007222
title_short	Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.
url	https://doi.org/10.1371/journal.pntd.0007222 https://doaj.org/article/2e2523b8d99d44728473b71cf25d0c74 http://europepmc.org/articles/PMC6756552?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735
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Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.

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