Increased genetic contribution to wellbeing during the COVID-19 pandemic.

Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously...
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Autor*in:	C A Robert Warmerdam [verfasserIn] Henry H Wiersma [verfasserIn] Pauline Lanting [verfasserIn] Alireza Ani [verfasserIn] Lifelines Corona Research Initiative [verfasserIn] Lifelines Cohort Study [verfasserIn] Marjolein X L Dijkema [verfasserIn] Harold Snieder [verfasserIn] Judith M Vonk [verfasserIn] H Marike Boezen [verfasserIn] Patrick Deelen [verfasserIn] Lude H Franke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: PLoS Genetics - Public Library of Science (PLoS), 2005, 18(2022), 5, p e1010135
Übergeordnetes Werk:	volume:18 ; year:2022 ; number:5, p e1010135

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.pgen.1010135

Katalog-ID:	DOAJ033284253

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allfields	10.1371/journal.pgen.1010135 doi (DE-627)DOAJ033284253 (DE-599)DOAJ1a4aa89018af4e0a9d130c6c007bef36 DE-627 ger DE-627 rakwb eng QH426-470 C A Robert Warmerdam verfasserin aut Increased genetic contribution to wellbeing during the COVID-19 pandemic. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static. Genetics Henry H Wiersma verfasserin aut Pauline Lanting verfasserin aut Alireza Ani verfasserin aut Lifelines Corona Research Initiative verfasserin aut Lifelines Cohort Study verfasserin aut Marjolein X L Dijkema verfasserin aut Harold Snieder verfasserin aut Judith M Vonk verfasserin aut H Marike Boezen verfasserin aut Patrick Deelen verfasserin aut Lude H Franke verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 18(2022), 5, p e1010135 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:18 year:2022 number:5, p e1010135 https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/article/1a4aa89018af4e0a9d130c6c007bef36 kostenfrei https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 5, p e1010135
spelling	10.1371/journal.pgen.1010135 doi (DE-627)DOAJ033284253 (DE-599)DOAJ1a4aa89018af4e0a9d130c6c007bef36 DE-627 ger DE-627 rakwb eng QH426-470 C A Robert Warmerdam verfasserin aut Increased genetic contribution to wellbeing during the COVID-19 pandemic. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static. Genetics Henry H Wiersma verfasserin aut Pauline Lanting verfasserin aut Alireza Ani verfasserin aut Lifelines Corona Research Initiative verfasserin aut Lifelines Cohort Study verfasserin aut Marjolein X L Dijkema verfasserin aut Harold Snieder verfasserin aut Judith M Vonk verfasserin aut H Marike Boezen verfasserin aut Patrick Deelen verfasserin aut Lude H Franke verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 18(2022), 5, p e1010135 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:18 year:2022 number:5, p e1010135 https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/article/1a4aa89018af4e0a9d130c6c007bef36 kostenfrei https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 5, p e1010135
allfields_unstemmed	10.1371/journal.pgen.1010135 doi (DE-627)DOAJ033284253 (DE-599)DOAJ1a4aa89018af4e0a9d130c6c007bef36 DE-627 ger DE-627 rakwb eng QH426-470 C A Robert Warmerdam verfasserin aut Increased genetic contribution to wellbeing during the COVID-19 pandemic. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static. Genetics Henry H Wiersma verfasserin aut Pauline Lanting verfasserin aut Alireza Ani verfasserin aut Lifelines Corona Research Initiative verfasserin aut Lifelines Cohort Study verfasserin aut Marjolein X L Dijkema verfasserin aut Harold Snieder verfasserin aut Judith M Vonk verfasserin aut H Marike Boezen verfasserin aut Patrick Deelen verfasserin aut Lude H Franke verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 18(2022), 5, p e1010135 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:18 year:2022 number:5, p e1010135 https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/article/1a4aa89018af4e0a9d130c6c007bef36 kostenfrei https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 5, p e1010135
allfieldsGer	10.1371/journal.pgen.1010135 doi (DE-627)DOAJ033284253 (DE-599)DOAJ1a4aa89018af4e0a9d130c6c007bef36 DE-627 ger DE-627 rakwb eng QH426-470 C A Robert Warmerdam verfasserin aut Increased genetic contribution to wellbeing during the COVID-19 pandemic. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static. Genetics Henry H Wiersma verfasserin aut Pauline Lanting verfasserin aut Alireza Ani verfasserin aut Lifelines Corona Research Initiative verfasserin aut Lifelines Cohort Study verfasserin aut Marjolein X L Dijkema verfasserin aut Harold Snieder verfasserin aut Judith M Vonk verfasserin aut H Marike Boezen verfasserin aut Patrick Deelen verfasserin aut Lude H Franke verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 18(2022), 5, p e1010135 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:18 year:2022 number:5, p e1010135 https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/article/1a4aa89018af4e0a9d130c6c007bef36 kostenfrei https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 5, p e1010135
allfieldsSound	10.1371/journal.pgen.1010135 doi (DE-627)DOAJ033284253 (DE-599)DOAJ1a4aa89018af4e0a9d130c6c007bef36 DE-627 ger DE-627 rakwb eng QH426-470 C A Robert Warmerdam verfasserin aut Increased genetic contribution to wellbeing during the COVID-19 pandemic. 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static. Genetics Henry H Wiersma verfasserin aut Pauline Lanting verfasserin aut Alireza Ani verfasserin aut Lifelines Corona Research Initiative verfasserin aut Lifelines Cohort Study verfasserin aut Marjolein X L Dijkema verfasserin aut Harold Snieder verfasserin aut Judith M Vonk verfasserin aut H Marike Boezen verfasserin aut Patrick Deelen verfasserin aut Lude H Franke verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 18(2022), 5, p e1010135 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:18 year:2022 number:5, p e1010135 https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/article/1a4aa89018af4e0a9d130c6c007bef36 kostenfrei https://doi.org/10.1371/journal.pgen.1010135 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 5, p e1010135
language	English
source	In PLoS Genetics 18(2022), 5, p e1010135 volume:18 year:2022 number:5, p e1010135
sourceStr	In PLoS Genetics 18(2022), 5, p e1010135 volume:18 year:2022 number:5, p e1010135
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genetics
isfreeaccess_bool	true
container_title	PLoS Genetics
authorswithroles_txt_mv	C A Robert Warmerdam @@aut@@ Henry H Wiersma @@aut@@ Pauline Lanting @@aut@@ Alireza Ani @@aut@@ Lifelines Corona Research Initiative @@aut@@ Lifelines Cohort Study @@aut@@ Marjolein X L Dijkema @@aut@@ Harold Snieder @@aut@@ Judith M Vonk @@aut@@ H Marike Boezen @@aut@@ Patrick Deelen @@aut@@ Lude H Franke @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	485248026
id	DOAJ033284253
language_de	englisch
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author	C A Robert Warmerdam
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title	Increased genetic contribution to wellbeing during the COVID-19 pandemic.
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title_full	Increased genetic contribution to wellbeing during the COVID-19 pandemic
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title_auth	Increased genetic contribution to wellbeing during the COVID-19 pandemic.
abstract	Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static.
abstractGer	Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static.
abstract_unstemmed	Physical and mental health are determined by an interplay between nature, for example genetics, and nurture, which encompasses experiences and exposures that can be short or long-lasting. The COVID-19 pandemic represents a unique situation in which whole communities were suddenly and simultaneously exposed to both the virus and the societal changes required to combat the virus. We studied 27,537 population-based biobank participants for whom we have genetic data and extensive longitudinal data collected via 19 questionnaires over 10 months, starting in March 2020. This allowed us to explore the interaction between genetics and the impact of the COVID-19 pandemic on individuals' wellbeing over time. We observe that genetics affected many aspects of wellbeing, but also that its impact on several phenotypes changed over time. Over the course of the pandemic, we observed that the genetic predisposition to life satisfaction had an increasing influence on perceived quality of life. We also estimated heritability and the proportion of variance explained by shared environment using variance components methods based on pedigree information and household composition. The results suggest that people's genetic constitution manifested more prominently over time, potentially due to social isolation driven by strict COVID-19 containment measures. Overall, our findings demonstrate that the relative contribution of genetic variation to complex phenotypes is dynamic rather than static.
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